IgG antibodies with peroxidase-like activity from the sera of healthy Wistar rats

AbstractVarious catalytic antibodies or abzymes (Abzs) have been detected recently in the sera of patients and animals with many autoimmune diseases, where their presence is most probably associated with autoimmunization. Normal humans or animals usually do not contain Abzs. In contrast, polyclonal Abzs from healthy humans and animals have an intrinsic superoxide dismutase activity and catalyze formation of H2O2 (Wentworth et al., 2000, Proc. Natl. Acad. Sci. USA; 2001, Science). Here, we present the first evidence showing that highly purified native IgGs from the sera of healthy Wistar rats interact with H2O2 and possess peroxidase-like activity. Specific peroxidase activity of IgG preparations from the sera of 10 rats varied in the range 1.6–27% as compared with that for horseradish peroxidase (100%). Antioxidant enzymes such as superoxide dismutases, catalases, and glutathione peroxidases are known to represent critical defence mechanisms for preventing oxidative modifications of DNA, proteins, and lipids. Antioxidant peroxidase activity of Abzs can also play an important role in the protection of organisms from oxidative stress as well as in oxidation of toxic compounds

Group analysis and exact solutions of a class of variable coefficient nonlinear telegraph equations

A complete group classification of a class of variable coefficient (1+1)-dimensional telegraph equations $f(x)u_{tt}=(H(u)u_x)_x+K(u)u_x$, is given, by using a compatibility method and additional equivalence transformations. A number of new interesting nonlinear invariant models which have non-trivial invariance algebras are obtained. Furthermore, the possible additional equivalence transformations between equations from the class under consideration are investigated. Exact solutions of special forms of these equations are also constructed via classical Lie method and generalized conditional transformations. Local conservation laws with characteristics of order 0 of the class under consideration are classified with respect to the group of equivalence transformations.Comment: 23 page

New results on group classification of nonlinear diffusion-convection equations

Using a new method and additional (conditional and partial) equivalence transformations, we performed group classification in a class of variable coefficient $(1+1)$-dimensional nonlinear diffusion-convection equations of the general form $f(x)u_t=(D(u)u_x)_x+K(u)u_x.$ We obtain new interesting cases of such equations with the density $f$ localized in space, which have large invariance algebra. Exact solutions of these equations are constructed. We also consider the problem of investigation of the possible local trasformations for an arbitrary pair of equations from the class under consideration, i.e. of describing all the possible partial equivalence transformations in this class.Comment: LaTeX2e, 19 page

Radiation-Induced Cerebro-Ophthalmic Effectsin Humans

: Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship “eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage