A folding inhibitor of the HIV-1 Protease

Being the HIV-1 Protease (HIV-1-PR) an essential enzyme in the viral life cycle, its inhibition can control AIDS. The folding of single domain proteins, like each of the monomers forming the HIV-1-PR homodimer, is controlled by local elementary structures (LES, folding units stabilized by strongly interacting, highly conserved, as a rule hydrophobic, amino acids). These LES have evolved over myriad of generations to recognize and strongly attract each other, so as to make the protein fold fast and be stable in its native conformation. Consequently, peptides displaying a sequence identical to those segments of the monomers associated with LES are expected to act as competitive inhibitors and thus destabilize the native structure of the enzyme. These inhibitors are unlikely to lead to escape mutants as they bind to the protease monomers through highly conserved amino acids which play an essential role in the folding process. The properties of one of the most promising inhibitors of the folding of the HIV-1-PR monomers found among these peptides is demonstrated with the help of spectrophotometric assays and CD spectroscopy

Continuous variable entanglement dynamics in structured reservoirs

We address the evolution of entanglement in bimodal continuous variable quantum systems interacting with two independent structured reservoirs. We derive an analytic expression for the entanglement of formation without performing the Markov and the secular approximations and study in details the entanglement dynamics for various types of structured reservoirs and for different reservoir temperatures, assuming the two modes initially excited in a twin-beam state. Our analytic solution allows us to identify three dynamical regimes characterized by different behaviors of the entanglement: the entanglement sudden death, the non-Markovian revival and the non-secular revival regimes. Remarkably, we find that, contrarily to the Markovian case, the short-time system-reservoir correlations in some cases destroy quickly the initial entanglement even at zero temperature.Comment: 12 pages, 8 figure

Casimir-Polder forces, boundary conditions and fluctuations

We review different aspects of the atom-atom and atom-wall Casimir-Polder forces. We first discuss the role of a boundary condition on the interatomic Casimir-Polder potential between two ground-state atoms, and give a physically transparent interpretation of the results in terms of vacuum fluctuations and image atomic dipoles. We then discuss the known atom-wall Casimir-Polder force for ground- and excited-state atoms, using a different method which is also suited for extension to time-dependent situations. Finally, we consider the fluctuation of the Casimir-Polder force between a ground-state atom and a conducting wall, and discuss possible observation of this force fluctuation.Comment: 5 page

Consequences of asteroid fragmentation during impact hazard mitigation

The consequences of the fragmentation of an Earth-threatening asteroid due to an attempted deflection are examined in this paper. The minimum required energy for a successful impulsive deflection of a threatening object is computed and compared to the energy required to break up a small size asteroid. The results show that the fragmentation of an asteroid that underwent an impulsive deflection, such as a kinetic impact or a nuclear explosion, is a very plausible event.Astatistical model is used to approximate the number and size of the fragments as well as the distribution of velocities at the instant after the deflection attempt takes place. This distribution of velocities is a function of the energy provided by the deflection attempt, whereas the number and size of the asteroidal fragments is a function of the size of the largest fragment. The model also takes into account the gravity forces that could lead to a reaggregation of the asteroid after fragmentation. The probability distribution of the pieces after the deflection is then propagated forward in time until the encounter with Earth. A probability damage factor (i.e., expected damage caused by a given size fragment multiplied by its impact probability) is then computed and analyzed for different plausible scenarios, characterized by different levels of deflection energies and lead times

Quantum resources for hybrid communication via qubit-oscillator states

We investigate a family of qubit-oscillator states as resources for hybrid quantum communication. They result from a mechanism of qubit-controlled displacement on the oscillator. For large displacements, we obtain analytical formulas for entanglement and other nonclassical correlations, such as entropic and geometric discord, in those states. We design two protocols for quantum communication using the considered resource states: a hybrid teleportation and a hybrid remote-state preparation. The latter, in its standard formulation, is shown to have a performance limited by the initial mixedness of the oscillator, echoing the behavior of the geometric discord. If one includes a further optimization over nonunitary correcting operations performed by the receiver, the performance is improved to match that of teleportation, which is directly linked to the amount of entanglement. Both protocols can then approach perfect efficiency even if the oscillator is originally highly thermal. We discuss the critical implications of these findings for the interpretation of general quantum correlations. © 2012 American Physical Society

Dynamical Casimir-Polder force between an atom and a conducting wall

The time-dependent Casimir-Polder force arising during the time evolution of an initially bare two-level atom, interacting with the radiation field and placed near a perfectly conducting wall, is considered. Initially the electromagnetic field is supposed to be in the vacuum state and the atom in its ground state. The analytical expression of the force as a function of time and atom-wall distance, is evaluated from the the time-dependent atom-field interaction energy. Physical features and limits of validity of the results are discussed in detail.Comment: 7 pages, 2 figure

pre treatment egfr t790m subclones in lung adenocarcinoma harboring activating mutation of egfr a positive prognostic factor for survival

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Mirror formation control in the vicinity of an asteroid

Two strategies are presented for the positioning and control of a spacecraft formation designed to focus sunlight onto a point on the surface of asteroid, thereby sublimating the material and ejecting debris creating thrust. In the first approach, the formation is located at artficial equilibrium points around the asteroid and controlled using the force from the solar radiation pressure. The second approach determines the optimal periodic formation orbits, subject to the gravitational perturbations from the asteroid, the solar radiation pressure and the control acceleration derived from a control law