Investigação da prolactina sérica como potencial marcador prognóstico no traumatismo crânio-encefálico severo em humanos

O objetivo do estudo foi correlacionar os níveis séricos de prolactina com o desfecho primário (sobrevivênciaou morte) em vítimas de TCE severo. Realizou-se estudo prospectivo de 45 homens e coleta deamostras seriadas de sangue venoso para correlacionar os níveis séricos de prolactina com desfecho clínico(alta da CTI ou morte após o trauma). Os níveis séricos médios de prolactina nos controles foram de10,86 ± 2,05 ng/ml e na primeira amostra das vítimas de TCE foram de 16.49 ± 9.76 ng/ml. Nos sobreviventes, os níveis foram de 16,12 ± 10,75 ng/ml, enquanto que nas vítimas fatais foram de 16,16 ±8,14 ng/ml. Os níveis de prolactina sérica não apresentaram correlação com desfecho fatal no TCEsevero, não apresentando poder preditivo de mortalidade no TCE severo em homens.Palavras-chave: traumatismo crânio-encefálico severo, prolactina sérica, desfecho clínico

Long-Lasting Efficacy of Radio Electric Asymmetric Conveyer Neuromodulation Treatment on Functional Dysmetria, an Adaptive Motor Behavior

BackgroundFluctuating asymmetry (FA) is widely defined as the deviation from perfect bilateral symmetry and is considered an epigenetic measure of environmental stress. Rinaldi and Fontani hypothesized that the FA morpho-functional changes originate from an adaptive motor behavior determined by functional alterations in the cerebellum and neural circuits, not caused by a lesion, but induced by environmental stress. They called this phenomenon functional dysmetria (FD). On this premise, they developed the radio electric asymmetric conveyer (REAC) technology, a neuromodulation technology aimed at optimizing the best neuro-psycho-motor strategies in relation to environmental interaction.AimsPrevious studies showed that specific REAC neuro postural optimization (NPO) treatment can induce stable FD recovery. This study aimed to verify the duration of the NPO effect in inducing the stable FD recovery over timeMaterials and methodsData were retrospectively collected from a population of 29,794 subjects who underwent a specific semiological FD assessment and received the NPO treatment, regardless of the pathology referred.ResultsThe analysis of the data collected by the various participants in the study led us to ascertain the disappearance of FD in 100% of the cases treated, with a stability of the result detected up to 18 years after the single administration of the REAC NPO treatment.ConclusionsThe REAC NPO neurobiological modulation treatment consisting of a single administration surprisingly maintains a very long efficacy in the correction of FD. This effect can be explained as the long-lasting capacity of the NPO treatment to induce greater functional efficiency of the brain dynamics as proven in previous studies