Thoracic Endometriosis Presenting with Bilateral Hydropneumothorax

Interesting Medical Imag

Studying the Clinical and Research Applications of the PennPet Explorer, a Long Axial Field-Of-View Pet Scanner

This thesis characterizes the long axial field-of-view (AFOV) PennPET Explorer scanner and studies the benefits for clinical and research applications using both measurements and Monte-Carlo simulations. The significant increase in photon sensitivity from extending the standard AFOV of a PET scanner by 3-6 times to 70-140 cm may allow for fast, low-dose imaging and more accurate quantification using a wide variety of radiotracers. Results of performance characterization, including sensitivity, count rate, spatial resolution, and lesion contrast, showed good correspondence across simulated and measured data, indicating an accurate model of the PennPET Explorer. A key clinical application, lesion detection, was studied with small lesions in both uniform and complex background distributions. Results showed that good lesion detectability and localization was achieved in the human subject for 30-60 s scan durations for the PennPET Explorer, compared to a 1.5-3 min scan on standard AFOV scanners. Dynamic imaging, often required for research applications, was studied using both simulated and measured datasets to quantify the accuracy and precision of key biologic parameters as a function of injected radioactive dose. Results showed that the dose can be lowered from 5-15 mCi, typical with a standard AFOV PET scanner, to 1-2 mCi with our long AFOV scanner while still maintaining accuracy and precision of key biologic parameters. These results were then used to design a dual tracer imaging study to sequentially image two radiotracers, labeled with the same radioisotope, to study complementary mechanisms of metabolism. Preliminary results indicate that a low, 3 mCi dose with the first tracer, imaged for an abbreviated 30 min, and followed by a 15 mCi injection of a second tracer resulted in time-activity curves (TACs) with low noise, and can be used to further optimize this new protocol. Combined, these results offer a quantitative framework for both static and dynamic imaging on the PennPET Explorer and can be applied to develop new clinical and research applications to leverage the enormous potential of long AFOV PET scanners

Evaluation of antioxidant and antimicrobial properties of finger millet polyphenols (Eleusine coracana)

Phenolic acids from finger millet (Eleusine coracana) milled fractions (whole flour, seed coat, 3%, 5% and 7%) were isolated and their antioxidant and antimicrobial properties were evaluated. Acidic methanol extracts from seed coat to whole flour were rich in polyphenol content and were found to be stable up to 48 h at pH 4, 7, and 9 as studied by ultraviolet spectroscopy. Diadzene, gallic, coumaric, syringic and vanillic acids were identified as major phenolic acids from the extracted phenolics. Diadzene content was highest in concentration in the 5% flour. The reducing power of seed coat extract was significantly (p < 0.05) higher than that of whole flour extract. Antioxidant activity (AA) as determined by the p-carotene-linoleic acid assay indicated that the AA was highest in seed coat extract (86%), whilst at the same concentration it was only 27% in the whole flour extract. The seed coat extract showed higher antimicrobial activity against Bacillus cereus and Aspergillus flavus compared to whole flour extract. From these observations, it can be inferred that the polyphenols are responsible for the microbial activity of the millet and the results indicate that potential exists to utilise finger millet seed coat as an alternative natural antioxidant and food preservative. (C) 2008 Elsevier Ltd. All rights reserved

Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation

Current developments in positron emission tomography focus on improving timing performance for scanners with time-of-flight (TOF) capability, and incorporating depth-of-interaction (DOI) information. Recent studies have shown that incorporating DOI correction in TOF detectors can improve timing resolution, and that DOI also becomes more important in long axial field-of-view scanners. We have previously reported the development of DOI-encoding detectors using phosphor-coated scintillation crystals; here we study the timing properties of those crystals to assess the feasibility of providing some level of DOI information without significantly degrading the timing performance. We used Monte Carlo simulations to provide a detailed understanding of light transport in phosphor-coated crystals which cannot be fully characterized experimentally. Our simulations used a custom reflectance model based on 3D crystal surface measurements. Lutetium oxyorthosilicate crystals were simulated with a phosphor coating in contact with the scintillator surfaces and an external diffuse reflector (teflon). Light output, energy resolution, and pulse shape showed excellent agreement with experimental data obtained on 3 × 3 × 10 mm³ crystals coupled to a photomultiplier tube. Scintillator intrinsic timing resolution was simulated with head-on and side-on configurations, confirming the trends observed experimentally. These results indicate that the model may be used to predict timing properties in phosphor-coated crystals and guide the coating for optimal DOI resolution/timing performance trade-off for a given crystal geometry. Simulation data suggested that a time stamp generated from early photoelectrons minimizes degradation of the timing resolution, thus making this method potentially more useful for TOF-DOI detectors than our initial experiments suggested. Finally, this approach could easily be extended to the study of timing properties in other scintillation crystals, with a range of treatments and materials attached to the surface

Abbreviated scan protocols to capture 18F-FDG kinetics for long axial FOV PET scanners.

PURPOSE Kinetic parameters from dynamic 18F-fluorodeoxyglucose (FDG) imaging offer complementary insights to the study of disease compared to static clinical imaging. However, dynamic imaging protocols are cumbersome due to the long acquisition time. Long axial field-of-view (LAFOV) PET scanners (> 70 cm) have two advantages for dynamic imaging over clinical PET scanners with a standard axial field-of-view (SAFOV; 16-30 cm). The large axial coverage enables multi-organ dynamic imaging in a single bed position, and the high sensitivity may enable clinically routine abbreviated dynamic imaging protocols. METHODS In this work, we studied two abbreviated protocols using data from a 65-min dynamic 18F-FDG scan: (A) dynamic imaging immediately post-injection (p.i.) for variable durations, and (B) dynamic imaging immediately p.i. for variable durations plus a 1-h p.i. (5-min-long) datapoint. Nine cancer patients were imaged on the Biograph Vision Quadra (Siemens Healthineers). Time-activity curves over the lesions (N = 39) were fitted using the Patlak graphical analysis and a 2-tissue-compartment (2C, k4 = 0) model for variable scan durations (5-60 min). Kinetic parameters from the complete dataset served as the reference. Lesions from all cancers were grouped into low, medium, and high flux groups, and bias and precision of Ki (Patlak) and Ki, K1, k2, and k3 (2C) were calculated for each group. RESULTS Using only early dynamic data with the 2C (or Patlak) model, accurate quantification of Ki required at least 50 (or 55) min of dynamic data for low flux lesions, at least 30 (or 40) min for medium flux lesions, and at least 15 (or 20) min for high flux lesions to achieve both 10% bias and precision. The addition of the final (5-min) datapoint allowed for accurate quantification of Ki with a bias and precision of 10% using only 10-15 min of early dynamic data for either model. CONCLUSION Dynamic imaging for 10-15 min immediately p.i. followed by a 5-min scan at 1-h p.i can accurately and precisely quantify 18F-FDG on a long axial FOV scanner, potentially allowing for more widespread use of dynamic 18F-FDG imaging