Calcium Triplet Synthesis

We present theoretical equivalent widths for the sum of the two strongest lines of the Calcium Triplet, CaT index, in the near-IR, using evolutionary techniques and the most recent models and observational data for this feature in individual stars. We compute the CaT index for Single Stellar Populations (instantaneous burst, standard Salpeter-type IMF) at four metallicities, Z=0.004, 0.008, 0.02 (solar) and 0.05, and ranging in age from very young bursts of star formation (few Myr) to old stellar populations, up to 17 gyr, representative of globular clusters, elliptical galaxies and bulges of spirals. The interpretation of the observed equivalent widths of CaT in different stellar systems is discussed. Composite-population models are also computed as a tool to interpret the CaT detections in star-forming regions, in order to disantangle between the component due to Red Supergiants stars, RSG, and the underlying, older, population. CaT is found to be an excellent metallicity-indicator for populations older than 1 Gyr, practically independent of the age. We discuss its application to remove the age- metallicity degeneracy, characteristic of all studies of galaxy evolution based on the usual integrated indices (both broad band colors and narrow band indices). The application of the models computed here to the analysis of a sample of elliptical galaxies will be discussed in a forthcoming paper (Gorgas et al. 1998).Comment: 17 pages, 7 figures, to be published in A&

Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms : revival of an old drug

BACKGROUND: It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY: We studied the activity of the veterinary drug oxantel pamoate against Trichuris muris, Ancylostoma ceylanicum and Necator americanus in vitro and in vivo. In addition, the dose-effect of oxantel pamoate combined with albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin was studied against T. muris in vitro and additive or synergistic combinations were followed up in vivo. PRINCIPAL FINDINGS: We calculated an ED50 of 4.7 mg/kg for oxantel pamoate against T. muris in mice. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53). Oxantel pamoate combined with levamisole, albendazole or ivermectin using ratios based on their ED50s revealed antagonistic effects in vivo (CI = 1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI = 0.15) was observed when oxantel pamoate-mebendazole was administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacked activity against Ancylostoma ceylanicum and Necator americanus in vivo. CONCLUSIONSIGNIFICANCE: Our study confirms the excellent trichuricidal properties of oxantel pamoate. Since the drug lacks activity against hookworms it is necessary to combine oxantel pamoate with a partner drug with anti-hookworm properties. Synergistic effects were observed for oxantel pamoate-mebendazole, hence this combination should be studied in more detail. Since, of the standard drugs, albendazole has the highest efficacy against hookworms, additional investigations on the combination effect of oxantel pamoate-albendazole should be launche

Constant of Motion for several one-dimensional systems and outlining the problem associated with getting their Hamiltonians

The constants of motion of the following systems are deduced: a relativistic particle with linear dissipation, a no-relativistic particle with a time explicitly depending force, a no-relativistic particle with a constant force and time depending mass, and a relativistic particle under a conservative force with position depending mass. The problem of getting the Hamiltonian for these systems is determined by getting the velocity as an explicit function of position and generalized linear momentum, and this problem can be solved a first approximation for the first above system.Comment: 15 pages, Te