Nowe wyniki badań własnych dysmutazy ponadtlenkowe3 i zamierzenia badawcze

Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej naukę

A selective photoaffinity probe that enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells

Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB2R), a promising GPCR to treat tissue injury and inflammatory diseases. LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorporated alkyne serves as ligation handle for the introduction of reporter groups. LEI121 enables target engagement studies and visualization of endogenously expressed CB2R in HL-60 as well as primary human immune cells using flow cytometry. Our findings show that strategically functionalized probes allow monitoring of endogenous GPCR expression and engagement in human cells using tandem photo-click chemistry and hold promise as biomarkers in translational drug discovery.Medicinal Chemistr

Macroscopic behavior of ferronematic gels and elastomers

We present the derivation of the macroscopic equations for uniaxial ferronematic gels and elastomers. We deal with the superparamagnetic case, where no permanent magnetization is present and the anisotropy is provided by the nematic director. We include the magnetization as an independent dynamic degree of freedom. As a consequence special emphasis is laid on possible static and dynamic cross-couplings between magnetization and the non-magnetic degrees of freedom, as director reorientations, flow, elastic strains and relative rotations between director and the elastic network. In particular, we find reversible dynamic cross-couplings among rotations of the magnetization, the director, relative rotations, and deformational flow that allow for new possibilities to manipulate such materials. Application of simple (oscillatory) shear induces, in general, a finite magnetization normal to the shear plane and a relative rotation in the shear plane, whose amplitudes are linear in the shear rate. Induced magnetization, induced relative rotation and the director are mutually orthogonal, with the director aligned obliquely to the flow direction. This orientation is independent of the shear rate and is a material property

Macroscopic behavior of ferrocholesteric liquid crystals and ferrocholesteric gels and elastomers

We study the influence of macroscopic chirality on the macroscopic properties of superparamagnetic liquid crystals and gels. Specifically we derive macroscopic dynamic equations for ferrocholesteric low molecular weight (LMW) liquid crystals and for ferrocholesteric gels and elastomers in the local description using the director field as macroscopic variable. The magnetization is treated as a macroscopic dynamic degree of freedom and its coupling to all other macroscopic variables is examined in detail. We incorporate into our dynamic analysis terms that are linear in a magnetic field giving rise to a number of cross-coupling terms not possible otherwise. A number of properties that are unique to the class of systems studied arise. As an example for a static property we find a term in the generalized energy which is linear in the electric field and quadratic in the magnetic field. We find that applying a magnetic field to a ferrocholesteric can lead to reversible electric currents, heat currents and concentration currents, which change their sign with a sign change of macroscopic chirality. As an example of a rather intriguing dissipative dynamic contribution we point out that for ferrocholesterics and for ferrocholesteric gels and elastomers in a magnetic field extensional flow leads to electric and heat currents