Collage Vol. I

JUDY COCHRAN: Editorial MICHAEL TANGEMAN: Haikus 2-5 ELISE ALBRECHT, CURTIS PLOWGIAN: French Calligrams 6 JASON VARDEN: Waiting 7 ALEXANDER GREEN: Photo 8 EDUARDO JARAMILLO: Formas violentas 9-11 GABRIELE DILLMANN: Photo 12 MICHAEL GOLDSBERG: Funf fur Ashley 13 MEGAN CARLSON: Fur Jared (German) 14 MAGGIE GLOVER: For Jared 14-15 CHRIS FAUR: Painting 16 LINDSEY ESHELMAN: Stuhl (The Chair) 17 HALLE THOMPSON, GWENN DOBOS: Les Bouches 18 JILL BOO: Lacheln (A Smile) 19 ALEXANDER GREEN: Photo 20 JULIA GRAWEMEYER: Villanelle 21, Expressions francaises (French Figures) 22-23, Pour me rappeler (So that I\u27d remember) 24 MICHEL CLIQUET: Photo 25 CHARLES O\u27KEEFE: Photos 26-28 LINE LERYCKE: Photos 29-32 MICHEL CLIQUET: Pierre docile (Docile Stone) 29-32 LOGAN FAVIA: Ataraxia 33 AVRITA SINGH: Absence 34 RACHEL GROTHEER: Compassion 35, Ligne (Line) 36, Nuit, douce nuit (Night, gentle night) 37, Rouge (Red) 38, Bonjour Bleu (Hello Blue) 39, Ligne courbe (Curved Line) 40 AMELIA DUNLAP: Compassion 41-42 KYLE SIMPSON: Separation 43 ALEXANDER GREEN: Photo 44 GWENN DOBOS: Ataraxia 45 SARAH SLOTKIN: Separation 46 CURTIS PLOWGIAN: Absence 47 ELISA VER MERRIS: Photo 48, Attachement (Attachment) 49 JENNIFER JOHNSON: Attachement (Attachment)50 ANNA KELLY: Compassion 51 RICHARD BANAHAN: Photo 52, Mon grand-pere et moit (My grandfather and me) 53 MEREDITH KATZ: Separation 54 BRENDA HEATER: Compassion 55 ZACHARY WALSH: Ataraxia 56 MICHEL CLIQUET: Photos 57-5

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.</p