48 research outputs found
Protecting quantum entanglement from leakage and qubit errors via repetitive parity measurements
Protecting quantum information from errors is essential for large-scale
quantum computation. Quantum error correction (QEC) encodes information in
entangled states of many qubits, and performs parity measurements to identify
errors without destroying the encoded information. However, traditional QEC
cannot handle leakage from the qubit computational space. Leakage affects
leading experimental platforms, based on trapped ions and superconducting
circuits, which use effective qubits within many-level physical systems. We
investigate how two-transmon entangled states evolve under repeated parity
measurements, and demonstrate the use of hidden Markov models to detect leakage
using only the record of parity measurement outcomes required for QEC. We show
the stabilization of Bell states over up to 26 parity measurements by
mitigating leakage using postselection, and correcting qubit errors using
Pauli-frame transformations. Our leakage identification method is
computationally efficient and thus compatible with real-time leakage tracking
and correction in larger quantum processors.Comment: 22 pages, 15 figure
Logical-qubit operations in an error-detecting surface code
We realize a suite of logical operations on a distance-two logical qubit
stabilized using repeated error detection cycles. Logical operations include
initialization into arbitrary states, measurement in the cardinal bases of the
Bloch sphere, and a universal set of single-qubit gates. For each type of
operation, we observe higher performance for fault-tolerant variants over
non-fault-tolerant variants, and quantify the difference through detailed
characterization. In particular, we demonstrate process tomography of logical
gates, using the notion of a logical Pauli transfer matrix. This integration of
high-fidelity logical operations with a scalable scheme for repeated
stabilization is a milestone on the road to quantum error correction with
higher-distance superconducting surface codes.Comment: 16 pages, 9 figures, 2 table
Advances on antiviral activity of Morus spp. plant extracts: Human coronavirus and virus-related respiratory tract infections in the spotlight
(1) Background: Viral respiratory infections cause life-threatening diseases in millions of people worldwide every year. Human coronavirus and several picornaviruses are responsible for worldwide epidemic outbreaks, thus representing a heavy burden to their hosts. In the absence of specific treatments for human viral infections, natural products offer an alternative in terms of innovative drug therapies. (2) Methods: We analyzed the antiviral properties of the leaves and stem bark of the mulberry tree (Morus spp.). We compared the antiviral activity of Morus spp. on enveloped and nonenveloped viral pathogens, such as human coronavirus (HCoV 229E) and different members of the Picornaviridae family—human poliovirus 1, human parechovirus 1 and 3, and human echovirus 11. The antiviral activity of 12 water and water–alcohol plant extracts of the leaves and stem bark of three different species of mulberry—Morus alba var. alba, Morus alba var. rosa, and Morus rubra—were evaluated. We also evaluated the antiviral activities of kuwanon G against HCoV-229E. (3) Results: Our results showed that several extracts reduced the viral titer and cytopathogenic effects (CPE). Leaves’ water-alcohol extracts exhibited maximum antiviral activity on human coronavirus, while stem bark and leaves’ water and water-alcohol extracts were the most effective on picornaviruses. (4) Conclusions: The analysis of the antiviral activities of Morus spp. offer promising applications in antiviral strategies
Quantum walks: a comprehensive review
Quantum walks, the quantum mechanical counterpart of classical random walks,
is an advanced tool for building quantum algorithms that has been recently
shown to constitute a universal model of quantum computation. Quantum walks is
now a solid field of research of quantum computation full of exciting open
problems for physicists, computer scientists, mathematicians and engineers.
In this paper we review theoretical advances on the foundations of both
discrete- and continuous-time quantum walks, together with the role that
randomness plays in quantum walks, the connections between the mathematical
models of coined discrete quantum walks and continuous quantum walks, the
quantumness of quantum walks, a summary of papers published on discrete quantum
walks and entanglement as well as a succinct review of experimental proposals
and realizations of discrete-time quantum walks. Furthermore, we have reviewed
several algorithms based on both discrete- and continuous-time quantum walks as
well as a most important result: the computational universality of both
continuous- and discrete- time quantum walks.Comment: Paper accepted for publication in Quantum Information Processing
Journa
HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway
CD4+ T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4+ T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD4+ T cells, rendering them susceptible to autologous NK killing. However, the mechanism of the 3S mediated NKp44L surface expression on CD4+ T cells remains unknown. Here, using immunoprecipitation, ELISA and blocking antibodies, we demonstrate that the 3S motif of HIV-1 gp41 binds to gC1qR on CD4+ T cells. We also show that the 3S peptide and two endogenous gC1qR ligands, C1q and HK, each trigger the translocation of pre-existing NKp44L molecules through a signaling cascade that involves sequential activation of PI3K, NADPH oxidase and p190 RhoGAP, and TC10 inactivation. The involvement of PI3K and NADPH oxidase derives from 2D PAGE experiments and the use of PIP3 and H2O2 as well as small molecule inhibitors to respectively induce and inhibit NKp44L surface expression. Using plasmid encoding wild type or mutated form of p190 RhoGAP, we show that 3S mediated NKp44L surface expression on CD4+ T cells is dependent on p190 RhoGAP. Finally, the role of TC10 in NKp44L surface induction was demonstrated by measuring Rho protein activity following 3S stimulation and using RNA interference. Thus, our results identify gC1qR as a new receptor of HIV-gp41 and demonstrate the signaling cascade it triggers. These findings identify potential mechanisms that new therapeutic strategies could use to prevent the CD4+ T cell depletion during HIV infection and provide further evidence of a detrimental role played by NK cells in CD4+ T cell depletion during HIV-1 infection
Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems
Human immunodeficiency virus type 1 (HIV-1) exploits a diverse array of host cell functions in order to replicate. This is mediated through a network of virus-host interactions. A variety of recent studies have catalogued this information. In particular the HIV-1, Human Protein Interaction Database (HHPID) has provided a unique depth of protein interaction detail. However, as a map of HIV-1 infection, the HHPID is problematic, as it contains curation error and redundancy; in addition, it is based on a heterogeneous set of experimental methods. Based on identifying shared patterns of HIV-host interaction, we have developed a novel methodology to delimit the core set of host-cellular functions and their associated perturbation from the HHPID. Initially, using biclustering, we identify 279 significant sets of host proteins that undergo the same types of interaction. The functional cohesiveness of these protein sets was validated using a human protein-protein interaction network, gene ontology annotation and sequence similarity. Next, using a distance measure, we group host protein sets and identify 37 distinct higher-level subsystems. We further demonstrate the biological significance of these subsystems by cross-referencing with global siRNA screens that have been used to detect host factors necessary for HIV-1 replication, and investigate the seemingly small intersect between these data sets. Our results highlight significant host-cell subsystems that are perturbed during the course of HIV-1 infection. Moreover, we characterise the patterns of interaction that contribute to these perturbations. Thus, our work disentangles the complex set of HIV-1-host protein interactions in the HHPID, reconciles these with siRNA screens and provides an accessible and interpretable map of infection
Bismuth oxide-related photocatalysts in green nanotechnology: A critical analysis
A survey addressing the uses of bismuth oxide in photocatalysis is presented. The richness of literature on such a specific topic proves the growing importance of this compound as a valid tool in pollution abatement and environmental decontamination. Many research groups have focused their activity on how to improve the photocatalytic properties of this semiconductor and several solutions have been adopted in the synthesis method, often based on wet-chemical processes. The impressive development of nanoscience helped in understanding and identifying process variables and operative conditions aiming at optimizing the yield of this promising photocatalytic material in the utilization of solar energy
Waste to energy for small cities: Economics versus carbon footprint
The main activities in Waste to Energy processing include waste generation, collection, separation, transportation, conversion, energy distribution, and ultimate waste disposal. Waste to Energy carries a trade-off between energy generation and the energy spent on collection, transport and treatment. Major performance indicators are cost, Waste Energy Potential Utilisation, and Carbon Footprint. This presentation analyses the potential of small cities to substitute part of their fossil fuels use by energy derived from Municipal Solid Waste. Several factors are considered in the study. The impact of waste logistics and the losses from energy distribution systems - natural gas pipeline and electricity grid are the most significant ones on the side of the supply chain. Further, the waste processing part, including the energy recovery from the waste involves the evaluation of a number of technologies linked with each other to form a distributed integrated processing system. In this study, the options for converting waste into thermal energy include (a) biogas digestion and burning and (b) waste incineration with off-gas cleaning. It is also possible to use the biogas in advanced cogeneration systems based on engines or fuel cells. The proposed procedure takes all these options into account and derives the optimal processing configuration from the waste generation to energy supply and residual waste deposition to landfill