Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies

We have demonstrated the feasibility of detecting and quantifying six cell-cycle-related nuclear markers (Ki67, pRb, p27, phospho-p27 (phosphorylated p27), phospho-pRb (phosphorylated pRb), phospho-HH3 (phosphorylated histone H3)) in plucked human scalp and eyebrow hair. Estimates of the proportion of plucked hairs that are lost or damaged during processing plus the intra- and intersubject variability of each nuclear marker with these techniques are provided to inform sizing decisions for intervention studies with drugs potentially impacting on these markers in the future

Search for B0B^{0} decays to invisible final states at Belle

We report a search for $B^{0}$ decays into invisible final states using a data sample of $657 \times 10^{6}$ $B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB $e^{+}e^{-}$ collider. The signal is identified by fully reconstructing a hadronic decay of the accompanying $B$ meson and requiring no other particles in the event. No significant signal is observed, and we obtain an upper limit of $1.3 \times 10^{-4}$ at the 90% confidence level for the branching fraction of invisible $B^{0}$ decay.Comment: 6 pages, 5 figures (9 figure files

Measurements of Branching Fractions and Time-dependent CP Violating Asymmetries in B0→D(∗)±D∓B^{0} \to D^{(*)\pm}D^{\mp} Decays

We report measurements of branching fractions and time-dependent CP asymmetries in $B^{0} \to D^{+}D^{-}$ and $B^{0} \to D^{*\pm}D^{\mp}$ decays using a data sample that contains $(772 \pm 11)\times 10^6 B\bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. We determine the branching fractions to be $\mathcal{B}(B^{0} \to D^{+}D^{-})=(2.12 \pm 0.16 \pm 0.18)\times 10^{-4}$ and $\mathcal{B}(B^{0} \to D^{*\pm}D^{\mp}=(6.14 \pm 0.29 \pm 0.50)\times 10^{-4}$. We measure CP asymmetry parameters $\mathcal{S}_{D^{+}D^{-}} = -1.06_{-0.14}^{+0.21} \pm 0.08$ and $\mathcal{C}_{D^{+}D^{-}} = -0.43 \pm 0.16 \pm 0.05$ in $B^{0} \to D^{+}D^{-}$ and $\mathcal{A}_{D^{*}D} = +0.06 \pm 0.05 \pm 0.02$, $\mathcal{S}_{D^{*}D} = -0.78 \pm 0.15 \pm 0.05$, $\mathcal{C}_{D^{*}D} = -0.01 \pm 0.11 \pm 0.04$, $\Delta\mathcal{S}_{D^{*}D} = -0.13 \pm 0.15 \pm 0.04$ and $\Delta\mathcal{C}_{D^{*}D} = +0.12 \pm 0.11 \pm 0.03$ in $B^{0} \to D^{*\pm}D^{\mp}$, where the first uncertainty is statistical and the second is systematic. We exclude the conservation of CP symmetry in both decays at equal to or greater than $4\sigma$ significance.Comment: 7 pages, 2 figure

Measurements of the Υ(10860)\Upsilon(10860) and Υ(11020)\Upsilon(11020) resonances via σ(e+e−→Υ(nS)π+π−)\sigma(e^+e^-\rightarrow\Upsilon(n{\rm S})\pi^+\pi^-)

We report new measurements of the total cross sections for $e^+e^-\to \Upsilon(n{\rm S})\pi^+\pi^-$ ($n$ = 1, 2, 3) and $e^+e^-\to b\bar b$ from a high-luminosity fine scan of the region $\sqrt{s} = 10.63$-$11.05$ GeV with the Belle detector. We observe that the $\Upsilon(n{\rm S})\pi^+\pi^-$ spectra have little or no non-resonant component and extract from them the masses and widths of $\Upsilon(10860)$ and $\Upsilon(11020)$ and their relative phase. We find $M_{10860}=(10891.1\pm3.2^{+0.6}_{-1.7})$ MeV/$c^2$ and \Gamma_{10860}=(53.7^{+7.1}_{-5.6}\,^{+1.3}_{-5.4}) MeV and report first measurements M_{11020}=(10987.5^{+6.4}_{-2.5}\,^{+9.0}_{-2.1}) MeV/$c^2$, \Gamma_{11020}=(61^{+9}_{-19}\,^{+2}_{-20}) MeV, and \phi_{\rm 11020}-\phi_{\rm 10860} = (-1.0\pm0.4\,^{+1.4}_{-0.1}) rad.Comment: University of Cincinnati preprint UCHEP-15-01, submitted to Physical Review D - Rapid Communication

Observation of B0→pΛˉD(∗)−B^{0} \rightarrow p\bar{\Lambda} D^{(*)-}

We report the first observation of the decays $B^0 \rightarrow p\bar{\Lambda} D^{(*)-}$. The data sample of $711$ fb$^{-1}$ used in this analysis corresponds to $772$ million $B\bar{B}$ pairs, collected at the $\Upsilon(4S)$ resonance by the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. We observe $19.8\sigma$ and $10.8\sigma$ excesses of events for the two decay modes and measure the branching fractions of $B^0 \rightarrow p\bar{\Lambda} D^{-}$ and $B^0 \rightarrow p\bar{\Lambda} D^{*-}$ to be $(25.1\pm2.6\pm3.5)\times10^{-6}$ and $(33.6\pm6.3\pm4.4)\times10^{-6}$, respectively, where the first uncertainties are statistical and the second are systematic. These results are not compatible with the predictions based on the generalized factorization approach. In addition, a threshold enhancement in the di-baryon ($p\bar{\Lambda}$) system is observed, consistent with that observed in similar $B$ decays.Comment: 16 pages, 3 figures and 3 tables, submitted to PR

Evidence for B- -> Ds+ K- l- nubar and search for B- -> Ds*+ K- l- nubar

We report measurements of the decays B- -> Ds(*)+ K- l- nubar in a data sample containing 657x10^6 BBbar pairs collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We observe a signal with a significance of 6 sigma for the combined Ds and Ds* modes and find the first evidence of the B- -> Ds+ K- l- nubar decay with a significance of 3.4 sigma. We measure the following branching fractions: BF(B- -> Ds+ K- l nubar) = (0.30 +/- 0.09(stat) +0.11 -0.08(syst)) x 10^-3 and BF(B- -> Ds*+ K- l- nubar) = (0.59 +/- 0.12(stat) +/- 0.15(syst)) x 10^-3 and set an upper limit BF(B- -> Ds*+ K- l- nubar) < 0.56 x 10^-3 at the 90% confidence level. We also present the first measurement of the Ds+K- invariant mass distribution in these decays, which is dominated by a prominent peak around 2.6 GeV/c^2.Comment: Submitted to Phys. Rev.

Observation of D0−Dˉ0D^0-\bar{D}^0 Mixing in e+e−e^+e^- Collisions

We observe $D^0-\bar{D}^0$ mixing in the decay $D^0\rightarrow K^+\pi^-$ using a data sample of integrated luminosity 976 fb$^{-1}$ collected with the Belle detector at the KEKB $e^+e^-$ asymmetric-energy collider. We measure the mixing parameters ${x'}^2 = (0.09\pm0.22)\times 10^{-3}$ and $y' = (4.6\pm3.4)\times 10^{-3}$ and the ratio of doubly Cabibbo-suppressed to Cabibbo-favored decay rates $R_D = (3.53\pm0.13)\times 10^{-3}$, where the uncertainties are statistical and systematic combined. Our measurement excludes the no-mixing hypothesis at the 5.1 standard deviation level.Comment: 6 pages, 4 figure

Inclusive cross sections for pairs of identified light charged hadrons and for single protons in e+e−e^+e^- at s=\sqrt{s}= 10.58 GeV

We report the first double differential cross sections of two charged pions and kaons ($e^+e^- \rightarrow hhX$) in electron-positron annihilation as a function of the fractional energies of the two hadrons for any charge and hadron combination. The dependence of these di-hadron cross sections on the topology (same, opposite-hemisphere or anywhere) is also studied with the help of the event shape variable thrust and its axis. The ratios of these di-hadron cross sections for different charges and hadron combinations directly shed light on the contributing fragmentation functions. For example, we find that the ratio of same-sign pion pairs over opposite-sign pion pairs drops toward higher fractional energies where disfavored fragmentation is expected to be suppressed. These di-hadron results are obtained from a $655\,{\rm fb}^{-1}$ data sample collected near the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. Extending the previously published single-pion and single-kaon cross sections, single-proton ($e^+e^- \rightarrow pX$) cross sections are extracted from a $159\,{\rm fb}^{-1}$ data sub-sample.Comment: submitted to PR