Unusual appearance of a pendulated gastric tumor : always think of GIST

Objective. To investigate the clinicopathological characteristics of gastrointestinal stromal tumor (GIST) with significant cystic changes and to assess the molecular genetic characteristics. Methods. In a 68-year-old man, a large abdominal tumoral mass was discovered incidentally. Computed tomography (CT) and magnetic resonance imaging (MRI) confirmed the presence of a large cystic lesion with multiple contrast-enhancing septae and papillary projections. No clear connection with any of the surrounding organs was identified. Malignancy could not be excluded, and surgery was indicated. During surgery, the large mass was found to be attached by a narrow stalk to the large curvature of the stomach. Results. The histological features and immunohistiochemical profile of the tumor cells (positivity for CD117 and CD34) were consistent with a gastrointestinal stromal tumor with a high risk of progressive disease according to the Fletcher classification. Diagnosis was confirmed by mutational analysis; this demonstrated mutation in exon 14 of PDGFRA. During the followup of 97 months, the patient had a cancer-free survival. Conclusions. This case demonstrates that gastrointestinal stromal tumors (GISTs) with extensive cystic degeneration should be considered in the differential diagnosis of a cystic abdominal mass

Taking a shine to it: How the preference for glossy stems from an innate need for water ☆ , ☆☆

Abstract Human beings are attracted to glossy objects. However, the investigation of whether this preference for glossy is a systematic bias, and the rationale for why, has received little or no attention. Drawing on an evolutionary psychology framework, we propose and test the hypothesis that the preference for glossy stems from an innate preference for fresh water as a valuable resource. In a set of six studies we demonstrate the preference for glossy among both adults and young children (studies 1A, 1B and 2) ruling out a socialization explanation, investigate the hypothesis that the preference for glossy stems from an innate need for water as a resource (studies 3 and 5) and, in addition, rule out the more superficial account of glossy = pretty (study 4). The interplay between the different perspectives, implications of the findings and future research directions are discussed

Prehospital paediatric emergencies in Belgium: an epidemiologic study

OBJECTIVES: In Belgium, emergency medical services (EMS) are staffed with a medical team if mandatory according to the regulation authority procedures. Children are involved in interventions, but no extensive data are available in the country. We analysed the characteristics of the children involved in EMS to gain better knowledge of the pathologies and the needs of these patients. MATERIALS AND METHODS: A retrospective review of all patients under 16 years of age dealt with by our EMS team during a 2-year period. RESULTS: During the 2010-2011 period, our EMS performed 229 paediatric missions. Most of the patients (76.0%) presented medical conditions. Seizure was the most common diagnosis (34.1%), including febrile convulsions in 55.1% of the cases. Five patients (2.2%) suffered a cardiac arrest. All of them died despite advanced life support. Two more patients died before or just after admission to the emergency room. In the subgroup of patients admitted to our hospital, 26.6% needed drug administration and 43.2% were discharged home after emergency room management. CONCLUSION: Prehospital paediatric emergencies are rarely life-threatening conditions and seldom need advanced medical interventions. However, the outcome of real life-threatening conditions is poor, therefore emphasizing the need for better trained teams

Are primary tumour standardized uptake value (PT SUVmax), total lesion glycolysis (TLG) and metabolic volume (MV) measured on FDG PET(CT) predictors of survival in non-small cell lung cancer (NSCLC) ?

info:eu-repo/semantics/publishe

La glycolyse lésionnelle totale et le volume métabolique en 18 FDG TEP TDM: deux nouveaux facteurs pronostiques dans le cancer bronchique non à petites cellules

(abstract 574). 15° Congrès de la société de pneumologie de langue française Lille.info:eu-repo/semantics/publishe

An updated meta-analysis (MA) of the literature assessing the prognostic role of primary tumour standardized uptake value (SUV) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) in non-small cell lung cancer (NSCLC)

P2.017info:eu-repo/semantics/publishe

Primary tumor standardized uptake value measured on fluorodeoxyglucose positron emission tomography is of prognostic value for survival in non-small cell lung cancer: update of a systematic review and meta-analysis by the European Lung Cancer Working Party for the International Association for the Study of Lung Cancer Staging Project.

Few validated prognostic factors are available for survival in patients with lung cancer. [F]-fluoro-2-deoxy-d-glucose positron emission tomography has been shown to be of additional value to conventional imaging for staging lung cancer. The prognostic value of this lung tumor metabolic activity was studied in a first systematic review of studies published until 2006.Journal ArticleMeta-AnalysisSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Cetuximab with hepatic arterial infusion of chemotherapy for the treatment of colorectal cancer liver metastases

Background: Both hepatic arterial infusion (HAI) of chemotherapy and cetuximab (CET) have interesting activity for the treatment of colorectal cancer liver metastases (CRC-LM). Patients and Methods: Intravenous CET with HAI oxaliplatin (OXA) or i.v. Irinotecan (IRI) followed by HAI of infusion of folic acid modulated 5 fluorouracil 5-FU/l-FA was administered to patients (pts) with CRC-LM who had failed at least one line of prior chemotherapy. Results: Eight pts received i.v. CET with HAI-OXA (5 pts) and i.v.-IRI (3 pts) and HAI-5-FU/l-FA. Adverse events: repeated grade 3 skin toxicity (1 pt), abdominal pain with elevated liver enzymes and asthenia (2 pts), duodenal ulcer (2 pts) with catheter migration and intestinal bleeding (1 pt), reversible interstitial pneumonitis (1 pt), and cystic bile duct dilatation (2 pts) with arteriobiliary fistulisation (1 pt). A partial response was documented in 5 pts (62%). The median time to progression was 8.7 months (95% confidence interval 8-14 months). Conclusion: Intravenous administration of CET with HAI of chemotherapy is feasible and has promising activity but is associated with specific toxicity