2 research outputs found
Molecular modeling and UV-vis spectroscopic studies on the mechanism of action of reversed chloroquine (RCQ)
Reversed chloroquine (RCQ) is a multiple ligand compound active against chloroquine-sensitive and resistant falciparum malaria. It is composed by a 4-aminoquinoline moiety (like that present in chloroquine (CQ)) joined to imipramine (IMP), a modulating agent that also showed intrinsic antiplasmodial activity against Brazilian Plasmodium falciparum isolates resistant to CQ. Molecular modeling and ultraviolet-visible spectroscopy (UV-vis) studies strongly suggest that the interaction between RCQ and heme is predominant through the quinoline moiety in a mechanism of action similar to that observed for CQ. (C) 2010 Elsevier Ltd. All rights reserved.CAPES-ProDoc[00019 03-8]Coordenação de Aperfeiçoamento de Pessoal de NÃvel Superior (CAPES)CNPqConselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq