1,706 research outputs found

    B.F. Skinner on Ethics and the Control of Retarded Persons

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    Educational Administration and Public Relations

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    This paper will attempt to analyze the qualifications and characteristics needed by an Educational Administrator to maintain desired public relations. Also Public Relations will be discussed as it applies to public schools in general and to the Educational Administrator specifically

    Themistokles’ Sanctuary of Artemis Aristoboule

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    Not Merely a Matter of Drawing Arrows: The Empirical Consequences of Measurement Model Specification and Recommendations for Practice

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    Understanding measurement model specification is especially important for hospitality research due to its cross-disciplinary nature and the prevalence of measures used in the field which are often central to the formative versus reflective debate (e.g., SERVQUAL, socioeconomic status). The current study contributes to this topic by providing empirically based prescriptive advice to drive better measurement model specification. Specifically, the decision-making procedures developed by this study can complement theoretical reasons for a model choice as well as help determine a correct model choice when theories are equivocal or non-existent. This study combines actual and simulated data to show that model fit statistics alone cannot determine which model specification is correct, but also that a correct measurement model will generate more accurate predictions within a model which in turn will offer more accurate managerial recommendations

    Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease

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    A seeming paradox of sickle cell disease is that patients do not suffer from a high prevalence of systemic hypertension in spite of endothelial dysfunction, chronic inflammation and vasculopathy. However, some patients do develop systolic hypertension and increased pulse pressure, an increasingly recognized major cardiovascular risk factor in other populations. Hence, we hypothesized that pulse pressure, unlike other blood pressure parameters, is independently associated with markers of hemolytic anemia and cardiovascular risk in sickle cell disease. We analyzed the correlates of pulse pressure in patients (n 5 661) enrolled in a multicenter international sickle cell trial. Markers of hemolysis were analyzed as independent variables and as a previously validated hemolytic index that includes multiple variables. We found that pulse pressure, not systolic, diastolic or mean arterial pressure, independently correlated with high reticulocyte count (beta 5 2.37, p 5 0.02) and high hemolytic index (beta 5 1.53, p50.002) in patients with homozygous sickle cell disease in two multiple linear regression models which include the markers of hemolysis as independent variables or the hemolytic index, respectively. Pulse pressure was also independently associated with elevated serum creatinine (beta 5 3.21, p 5 0.02), and with proteinuria (beta 5 2.52, p 5 0.04). These results from the largest sickle cell disease cohort to date since the Cooperative Study of Sickle Cell Disease show that pulse pressure is independently associated with hemolysis, proteinuria and chronic kidney disease. We propose that high pulse pressure may be a risk factor for clinical complications of vascular dysfunction in sickle cell disease. Longitudinal and mechanistic studies should be conducted to confirm these hypotheses
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