The professional career of Mark Krueger

Dr. Mark Krueger, Professor of Youth Work at the University of Wisconsin-Milwaukee, a venerable and internationally respected and beloved practitioner, scholar, and leader in child and youth work has died. His career spanned more than 40 years and benefited not only children and youth worldwide, but also the careers of child and youth workers who were empowered by his teaching, his leadership, his numerous writings, his advocacy, and his personal caring, compassion, creativity and modesty. These qualities were infused in his numerous activities that embodied his focus on the interactive, dynamic and relational aspects of child and youth work establishing it as a crucial and unique human service

Agrarstruktur in Ghandruk und Umgebung : Schwerpunkt Ackerbau und Hausgärten

Immunity to human influenza A virus (IAV) infection is only partially understood. Broadly non-neutralizing antibodies may assist in reducing disease but have not been well characterized.We measured internalization of opsonized, influenza protein-coated fluorescent beads and live IAV into a monocytic cell line to study antibody-dependent phagocytosis (ADP) against multiple influenza hemagglutinin (HA) subtypes. We analyzed influenza HA-specific ADP in healthy human donors, in preparations of intravenous immunoglobulin (IVIG), and following IAV infection of humans and macaques.We found that both sera from healthy adults and IVIG preparations had broad ADP to multiple seasonal HA proteins and weak cross-reactive ADP to non-circulating HA proteins. The ADP in experimentally influenza-infected macaque plasma and naturally influenza-infected human sera mediated phagocytosis of both homologous and heterologous IAVs. Further, the IAV phagocytosed in an antibody-mediated manner had reduced infectivity in vitro.We conclude that IAV infections in humans and macaques leads to the development of influenza-specific ADP that can clear IAV infection in vitro. Repeated exposure of humans to multiple IAV infections likely leads to the development of ADP that is cross-reactive to strains not previously encountered. Further analyses of the protective capacity of broadly reactive influenza-specific ADP is warranted