Stratégies d’intervention avec des jeunes en difficulté: prélude pour une clinique psychosociale

Con los jóvenes que están en fracaso escolar , que pierden confianza en sí mismos y en los demás y para los que parece que futuro alguno les aguarde, se solicita de los profesionales que encuentren nuevas formas de hacerse cargo, abiertas a la complejidad de las situaciones y de la transversalidad de las redes sociales. En este artículo se presentan diferentes ejemplos persiguiendo mantener viva la relación entre las personas en dificultad y los profesionales implicados.Every professional is urged to find new ways to help young school leavers having lost confidence in themselves and in the others, and seeing no future. Ways are to be open to account for the complexity of situations and to the social network’s transversality. The article presents examples dealing with the relationships between people with problems and social workers

Interim FDG-PET Scan in Hodgkin's Lymphoma: Hopes and Caveats

FDG-PET has recently emerged as an important tool for the management of Hodgkins lymphoma. Although its use for initial staging and response evaluation at the end of treatment is well established, the place of interim PET for response assessment and subsequent treatment tailoring is still quite controversial. The use of interim PET after a few cycles of chemotherapy may allow treatment reduction for good responders, leading to lesser treatment toxicities as well as early treatment adaptation for bad responders with a potential higher chance for cure. Interpretation of interim PET is a rapidly moving field. Actually, visual interpretation is preferred over quantitative interpretation in this situation. The notion of minimal residual uptake emerged for faint persisting FDG uptake, but has evolved during the recent years. Guidelines using mediastinum and liver as references have been proposed at the expert meeting in Deauville 2009. Actually, several trials are ongoing both for localised and advanced disease to evaluate the FDG-PET potential for early treatment monitoring and tailoring. Until the results of these prospective randomized trials become available, treatment changes according to the interim PET results should remain inappropriate and limited to well-conducted clinical trials

Des représentations spatiales de concepts : pour quoi faire ?

Dans cet article, nous présentons deux outils de représentation spatiale de concepts : la carte conceptuelle et le réseau terminologique. Nous expliquons leurs objectifs, les différentes étapes de leur construction et mettons en évidence leurs avantages, leur complémentarité et leurs limites. La carte conceptuelle met particulièrement l'accent sur la logique disciplinaire sous-jacente au discours didactique. Le réseau terminologique permet de visualiser les liens effectivement formulés par l'enseignant entre les termes, la densité et le sens de ces relations entre termes

Molecular Level in Silico Studies for Oncology. Direct Models Review

The combination of therapy and diagnostics in one process "theranostics" is a trend in a modern medicine, especially in oncology. Such an approach requires development and usage of multifunctional hybrid nanoparticles with a hierarchical structure. Numerical methods and mathematical models play a significant role in the design of the hierarchical nanoparticles and allow looking inside the nanoscale mechanisms of agent-cell interactions. The current position of in silico approach in biomedicine and oncology is discussed. The review of the molecular level in silico studies in oncology, which are using the direct models, is presented

Communication d'un savoir scientifique en classe De la verbalisation au concept d'équilibre chimique

Cet article présente deux outils visant à décrire et à analyser le discours oral d'un enseignant en situation didactique. L'étude porte sur trois professeurs de sciences du lycée, en Belgique francophone, introduisant le concept d'équilibre chimique. La première approche développée consiste en un repérage et un comptage des termes utilisés dans le discours, la seconde en une représentation schématique d'associations de termes réalisées par chaque enseignant face à des élèves de 16 à 17 ans

Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging

We present development and human application of a method for determining the regional cerebral density of the type 2 vesicular monoamine transporter (VMAT2) using positron emission tomography (PET) and [ 11 C]dihydrotetrabenazine (DTBZ). Previous animal studies indicate striatal VMAT2 density is linearly related to the integrity of substantia nigra dopamine neurons and is not subject to drug-or lesion-compensatory regulation. In the present studies, kinetic compartmental modeling was employed to estimate blood-brain [ 11 C]DTBZ transport ( K 1 ,) and VMAT2 binding site density (tissue-to-plasma DTBZ distribution volume, DV )from the cerebral and plasma DTBZ time courses her intravenous tracer injection. In controls, we found reductions of putamen DTBZ DV with advancing age, corresponding to losses of 0.77% per year in specific VMAT2 binding. Parkinson's disease (PD) patients had reduction in specific DTBZ DV in the putamen (−61%) and in the caudate nucleus (−43%). There was no overlap of lowest specific putamen DTBZ DV between individual elderly controls and PD patients. The present results indicate the suitability of [ 11 C]DTBZ PET for objective quantification of nigrostriatal integrity, including evaluation of PD progression and its possible therapeutic modification.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50362/1/410400609_ftp.pd

Eccrine Porocarcinoma: A Challenging Diagnostic and Therapeutic Tumoral Entity

Eccrine porocarcinoma is a rare malignant cutaneous tumor with high rates of extracutaneous spread, and its diagnosis and management can be quite challenging. This is a case of an 82-year-old woman presenting with an asymptomatic and chronic pubic skin lesion for whom the work-up required many investigations and procedures to confirm the diagnosis of metastatic eccrine porocarcinoma. Indeed, the patient underwent a wide local excision of the skin lesion, imaging with an FDG-PET scan, a colonoscopy, and two inguinal node dissections. As illustrated in this case, surgery should always be considered to achieve disease remission. Other treatments such as chemotherapy and radiotherapy have also been reported in the literature without clear standard guidelines