The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

Cancer Signaling networks and Molecular Therapeutic

Optimising the future Belgian offshore wind farm monitoring programme

Six years of monitoring triggered a reflection on how to best continue with the monitoring programme. The basic monitoring has to be rationalised at the level of the likelihood of impact detection, the meaningfulness of impact size and representativeness of the findings. Targeted monitoring should continue to disentangle processes behind the observed impact, for instance the overarching artificial reef effect created by wind farms. The major challenge however remains to achieve a reliable assessment of the cumulative impacts. Continuing consultation and collaboration within the Belgian offshore wind farm monitoring team and with foreign marine scientists and managers will ensure an optimisation of the future monitoring programme

Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials that is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]

The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

AbstractExtensive cDNA analysis demonstrated that all human and mouse protocadherin-β genes are one-exon genes. The protein sequences of these genes are highly conserved, especially the three most membrane-proximal extracellular domains. Phylogenetic analysis suggested that this unique gene family evolved by duplication of one single protocadherin-β gene to 15 copies. The final difference in the number of protocadherin-β genes in man (#19) and mouse (#22) is probably caused by duplications later in evolution. The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-β gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-β genes

Bradycardia, Ventricular pauses, Syncope, and sports

16 athletic patients were examined because of syncope, Stokes-Adams attacks, or both. The life-threatening condition required pacemaker implantation in 7 patients. 8 of the 9 other subjects became symptom-free after stopping heavy physical training. 37 top-ranking athletes underwent 24 h Holter monitoring. Pauses longer than 2 s occurred in 19% and resulted from sinus arrest. The longest pause lasted 2.5 s. Second-degree atrioventricular block was noted in 13%