Treatment and control: a qualitative study of older mentally ill offenders' perceptions on their detention and care trajectory

The life of older mentally ill offenders (OMIOs) is often characterized by successive periods of detention in correctional facilities, admissions to psychiatric services, and unsuccessful attempts to live independently. Through in-depth interviews, eight personal stories from OMIOs under supervision of the commission of social defence in Ghent (Belgium) were analyzed in the phenomenological research tradition. The results of the study reveal that OMIOs had more positive and less negative experiences in prison settings when compared with other institutional care settings. Independent living, unsurprisingly, is favored the most. This may be due to the fact that the latter option fosters personal competence, feelings of being useful, personal choices, and contact with the outside world. Even in later lifetime, a combined approach of risk assessment with improvement of well-being remains valuable to stimulate offender rehabilitation. Therefore, more research into concepts that could be used to support OMIOs needs further consideration

The bumpy road to change : a retrospective qualitative study on formerly detained adolescents' trajectories towards better lives

Background: Currently, the risk-oriented focus in forensic youth care is increasingly complemented by a growing interest in strengths-based approaches. Knowledge on how detention and the subsequent period in the community is experienced by adolescents, and which elements are helpful in achieving better lives can contribute to this emerging field. The current study aimed to retrospectively explore adolescents’ experiences from the moment they were detained until six to 12 months after they left the institution, identifying positive aspects and strengths. Methods: In-depth interviews were conducted with 25 adolescents (both boys and girls, 15-18 years old) on average eight months after discharge from a closed institution in Belgium. A thematic analysis was performed using NVivo 11. Results: Five themes and corresponding subthemes were identified: (1) adolescents’ own strengths and resilience, (2) re-building personally valued lives, (3) making sense of past experiences, (4) moving away from a harmful lifestyle, and (5) (in-)formal supports. Most adolescents are on their way to finding a new balance in life, however, for a subgroup of them, this is still fragile. Adolescents highly emphasize the importance of feeling closely connected to at least one person; to receive practical help with regard to finances, work and housing; and to be able to experience pleasure and joy in their lives. Conclusions: Adolescents’ narratives suggest that starting a journey towards a normative good life often goes along with an initial difficult period because of a sense of loss with regard to their former life. This stresses the importance of targeting rehabilitation towards prosocial goals and enhancing adolescents’ quality of life on those life domains that matter most for them. Furthermore, we stress the importance of helping adolescents in overcoming structural barriers as a first step in supporting them in their trajectories towards better lives

Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a unique GPR84 negative allosteric modulator undergoing evaluation in a phase II clinical trial

GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) that displays relatively low potency and selectivity, a clear need exists for an improved modulator. Structural optimization of GPR84 antagonist hit 1, identified through high-throughput screening, led to the identification of potent and selective GPR84 inhibitor GLPG1205 (36). Compared with the initial hit, 36 showed improved potency in a guanosine 5′-O-[γ-thio]triphosphate assay, exhibited metabolic stability, and lacked activity against phosphodiesterase-4. This novel pharmacological tool allowed investigation of the therapeutic potential of GPR84 inhibition. At once-daily doses of 3 and 10 mg/kg, GLPG1205 reduced disease activity index score and neutrophil infiltration in a mouse dextran sodium sulfate-induced chronic inflammatory bowel disease model, with efficacy similar to positive-control compound sulfasalazine. The drug discovery steps leading to GLPG1205 identification, currently under phase II clinical investigation, are described herein

Adolescents' quality of life and mental health needs during the initial phase in a closed institution

This study investigated adolescents’ Quality of Life and mental health needs during the first weeks in a closed institution for mandatory care and treatment to inform (gender-specific) rehabilitation. Questionnaires concerning socio-demographic variables, Quality of Life and mental health needs were administered (n ¼ 182; 90 boys and 92 girls; mean age ¼ 16.2). Given the high prevalence of mental health needs in this study population and their significant negative correlation with QoL, we argue for a holistic view on rehabilitation and to broaden treatment aims in youth forensic care by including not only determinants of recidivism but also determinants of QoL

Adolescents’ quality of life and mental health needs during the initial phase of detention

This study investigated adolescents’ Quality of Life and mental health needs during the first weeks in a closed institution for mandatory care and treatment to inform (gender-specific) rehabilitation. Questionnaires concerning socio-demographic variables, Quality of Life and mental health needs were administered (n ¼ 182; 90 boys and 92 girls; mean age ¼ 16.2). Given the high prevalence of mental health needs in this study population and their significant negative correlation with QoL, we argue for a holistic view on rehabilitation and to broaden treatment aims in youth forensic care by including not only determinants of recidivism but also determinants of QoL