El Niño Southern Oscillation signal in a new East Antarctic ice core, Mount Brown South

Abstract. Paleoclimate archives, such as high-resolution ice core records, provide a means to investigate long-term (multi-centennial) climate variability. Until recently, the Law Dome (Dome Summit South) ice core record remained one of few long-term high-resolution records in East Antarctica. A new ice core drilled in 2017/2018 at Mount Brown South, approximately 1000 km west of Law Dome, provides an additional high-resolution record that will likely span the last millennium in the Indian Ocean sector of East Antarctica. Here, we compare snowfall accumulation rates and sea salt concentrations in the upper portion (~21 m) of the Mount Brown South record, and an updated Law Dome record over the period 1975–2016. Annual sea salt concentrations from the Mount Brown South record preserves a stronger signal for the El Niño-Southern Oscillation (ENSO; in austral winter and spring, r = 0.521, p r = −0.387, p = 0.018, Niño 3.4). The Mount Brown South and Law Dome ice cores record inverse signals for the ENSO, suggesting the occurrence of distinct moisture and aerosol intrusions. We suggest that ENSO-related sea surface temperature anomalies in the equatorial Pacific drive atmospheric teleconnections in the southern mid-latitudes. These anomalies are associated with a weakening (strengthening) of regional westerly winds to the north of Mount Brown South that corresponds to years of low (high) sea salt deposition at Mount Brown South during La Niña (El Niño) events. The Mount Brown South annual sea salt record when complete will offer a new proxy record for reconstructions of the ENSO over the recent millennium, along with improved understanding of regional atmospheric variability in the southern Indian Ocean in addition to that derived from Law Dome

A historical perspective on the discovery of statins

Cholesterol is essential for the functioning of all human organs, but it is nevertheless the cause of coronary heart disease. Over the course of nearly a century of investigation, scientists have developed several lines of evidence that establish the causal connection between blood cholesterol, atherosclerosis, and coronary heart disease. Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs—the statins—that lower cholesterol levels in blood and reduce the frequency of heart attacks

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

An independently dated 2000-yr volcanic record from Law Dome, East Antarctica, including a new perspective on the dating of the 1450s CE eruption of Kuwae, Vanuatu

Volcanic eruptions are an important cause of natural climate variability. In order to improve the accuracy of climate models, precise dating and magnitude of the climatic effects of past volcanism are necessary. Here we present a 2000-yr record of Southern Hemisphere volcanism recorded in ice cores from the high accumulation Law Dome site, East Antarctica. The ice cores were analysed for a suite of chemistry signals and are independently dated via annual layer counting, with 11 ambiguous years at 23 BCE, which has presently the lowest error of all published long Antarctic ice cores. Independently dated records are important to avoid circular dating where volcanic signatures are assigned a date from some external information rather than using the date it is found in the ice core. Forty-five volcanic events have been identified using the sulphate chemistry of the Law Dome record. The low dating error and comparison with the NGRIP (North Greenland Ice Core Project) volcanic records (on the GICC05 timescale) suggest Law Dome is the most accurately dated Antarctic volcanic dataset, which will improve the dating of individual volcanic events and potentially allow better correlation between ice core records, leading to improvements in global volcanic forcing datasets. One of the most important volcanic events of the last two millennia is the large 1450s CE event, usually assigned to the eruption of Kuwae, Vanuatu. In this study, we review the evidence surrounding the presently accepted date for this event, and make the case that two separate eruptions have caused confusion in the assignment of this event. Volcanic sulphate deposition estimates are important for modelling the climatic response to eruptions. The largest volcanic sulphate events in our record are dated at 1458 CE (Kuwae?, Vanuatu), 1257 and 422 CE (unidentified)