5 research outputs found

    Sage-Bionetworks/Genie: v16.1.0

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    <h2>What's Changed</h2> <ul> <li>[GEN-851] Hotfix pin cbioportal repo version by @rxu17 in https://github.com/Sage-Bionetworks/Genie/pull/535</li> <li>[GEN-846] & [GEN-845] Ignore case and allow underscores in cross-validate by @rxu17 in https://github.com/Sage-Bionetworks/Genie/pull/536</li> <li>[GEN-834] Disable data guide generation by @rxu17 in https://github.com/Sage-Bionetworks/Genie/pull/537</li> <li>[GEN-905] - Change error of start position > end position to a warning by @thomasyu888 in https://github.com/Sage-Bionetworks/Genie/pull/538</li> <li>[GEN-809] Validate allele columns by @rxu17 in https://github.com/Sage-Bionetworks/Genie/pull/539</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/Sage-Bionetworks/Genie/compare/v16.0.0...v16.1.0</p&gt

    Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia.

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    Mutations in Fms-like tyrosine kinase 3 (FLT3) are common drivers in acute myeloid leukemia (AML) yet FLT3 inhibitors only provide modest clinical benefit. Prior work has shown that inhibitors of lysine-specific demethylase 1 (LSD1) enhance kinase inhibitor activity in AML. Here we show that combined LSD1 and FLT3 inhibition induces synergistic cell death in FLT3-mutant AML. Multi-omic profiling revealed that the drug combination disrupts STAT5, LSD1, and GFI1 binding at the MYC blood super-enhancer, suppressing super-enhancer accessibility as well as MYC expression and activity. The drug combination simultaneously results in the accumulation of repressive H3K9me1 methylation, an LSD1 substrate, at MYC target genes. We validated these findings in 72 primary AML samples with the nearly every sample demonstrating synergistic responses to the drug combination. Collectively, these studies reveal how epigenetic therapies augment the activity of kinase inhibitors in FLT3-ITD AML. Implications: This work establishes the synergistic efficacy of combined FLT3 and LSD1 inhibition in FLT3-ITD AML by disrupting STAT5 and GFI1 binding at the MYC blood-specific super-enhancer complex
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