13 research outputs found
Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: a propensity-matched analysis (vol 405, pg 851, 2020)
An Erratum to this paper has been published:Vascular Surger
Timing of Parathyroidectomy Does Not Influence Renal Function After Kidney Transplantation
Background Parathyroidectomy (PTx) is the treatment of choice for end-stage renal disease (ESRD) patients with
therapy-resistant hyperparathyroidism (HPT). The optimal timing of PTx for ESRD-related HPT—before or after
kidney transplantation (KTx)—is subject of debate.
Methods Patients with ESRD-related HPT who underwent both PTx and KTx between 1994 and 2015 were included
in a multicenter retrospective study in four university hospitals. Two groups were formed according to treatment
sequence: PTx before KTx (PTxKTx) and PTx after KTx (KTxPTx). Primary endpoint was renal function (eGFR,
CKD-EPI) between both groups at several time points post-transplantation. Correlation between the timing of PTx
and KTx and the course of eGFR was assessed using generalized estimating equations (GEE).
Results The PTxKTx group consisted of 102 (55.1%) and the KTxPTx group of 83 (44.9%) patients. Recipient age,
donor type, PTx type, and pre-KTx PTH levels were significantly different between groups. At 5 years after
transplantation, eGFR was similar in the PTxKTx group (eGFR 44.5 ± 4.0 ml/min/1.73 m2
) and KTxPTx group
(40.0 ± 6.4 ml/min/1.73 m2
, p = 0.43). The unadjusted GEE model showed that timing of PTx was not correlated
with graft function over time (mean difference -1.0 ml/min/1.73 m2
, 95% confidence interval -8.4 to 6.4,
p = 0.79). Adjustment for potential confounders including recipient age and sex, various donor characteristics, PTx
type, and PTH levels did not materially influence the results.
Conclusions In this multicenter cohort study, timing of PTx before or after KTx does not independently impact graft
function over time
Relation of 18-F-Dopa PET with hypokinesia-rigidity, tremor and freezing in Parkinson’s disease
Introduction: In this retrospective study concerning patients with Parkinson's disease (PD) scanned with 18-F-Dopa PET (NÂ =Â 129), we looked for an association between reduced 18-F-Dopa uptake and the key PD symptoms tremor and hypokinesia-rigidity. We hypothesized to find a stronger correlation between dopaminergic depletion in the striatum and hypokinesia-rigidity compared to tremor.
Methods: The onset side of symptoms (documented for 102 patients) as well as the first registered UPDRS (available for 79 patients) was used to correlate with F-Dopa uptake values in the caudate nucleus and putamen in this large retrospective sample.
Results: Reduced F-Dopa uptake was contralateral to hypokinesia-rigidity symptoms and correlated with its severity (quantified by UPDRS). For tremor severity, no correlation was seen with F-Dopa reduction. Furthermore, freezing of gait correlated with reduced F-Dopa uptake in the putamen of the right hemisphere.
Conclusion and discussion: Our results, obtained in a large patient group, provides support for the concept that tremor in PD is not only based on a dopamine related pathway but may rely on a different pathway
Redirection of anti-leukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.
Redirection of anti-leukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.
K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter
During hypovolemia and hyperkalemia, the kidneys defend homeostasis by Na+ retention and K+ secretion, respectively. Aldosterone mediates both effects, but it is unclear how the same hormone can evoke such different responses. To address this, we mimicked hypovolemia and hyperkalemia in four groups of rats with a control diet, low-Na+ diet, high-K+ diet, or combined diet. The low-Na+ and combined diets increased plasma and kidney ANG II. The low-Na+ and high-K+ diets increased plasma aldosterone to a similar degree (3-fold), whereas the combined diet increased aldosterone to a greater extent (10-fold). Despite similar Na+ intake and higher aldosterone, the high-K+ and combined diets caused a greater natriuresis than the control and low-Na+ diets, respectively (P < 0.001 for both). This K+-induced natriuresis was accompanied by a decreased abundance but not phosphorylation of the Na+-Cl- cotransporter (NCC). In contrast, the epithelial Na+ channel (ENaC) increased in parallel with aldosterone, showing the highest expression with the combined diet. The high-K+ and combined diets also incr
Na trilha
Orientadora: Liliani Marilia TiepoloMonografia (graduação) - Universidade Federal do Paraná, Graduação em Gestão Ambienta
Recognition of Cladosporium fulvum Ecp2 elicitor by non-host Nicotiana spp. is mediated by a single dominant gene that is not homologous to known Cf-genes
Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis
Vascular Surger