The dynamical distance and intrinsic structure of the globular cluster omega Centauri

We determine the dynamical distance D, inclination i, mass-to-light ratio M/L and the intrinsic orbital structure of the globular cluster omega Cen, by fitting axisymmetric dynamical models to the ground-based proper motions of van Leeuwen et al. and line-of-sight velocities from four independent data-sets. We correct the observed velocities for perspective rotation caused by the space motion of the cluster, and show that the residual solid-body rotation component in the proper motions can be taken out without any modelling other than assuming axisymmetry. This also provides a tight constraint on D tan i. Application of our axisymmetric implementation of Schwarzschild's orbit superposition method to omega Cen reveals no dynamical evidence for a significant radial dependence of M/L. The best-fit dynamical model has a stellar V-band mass-to-light ratio M/L_V = 2.5 +/- 0.1 M_sun/L_sun and an inclination i = 50 +/- 4 degrees, which corresponds to an average intrinsic axial ratio of 0.78 +/- 0.03. The best-fit dynamical distance D = 4.8 +/- 0.3 kpc (distance modulus 13.75 +/- 0.13 mag) is significantly larger than obtained by means of simple spherical or constant-anisotropy axisymmetric dynamical models, and is consistent with the canonical value 5.0 +/- 0.2 kpc obtained by photometric methods. The total mass of the cluster is (2.5 +/- 0.3) x 10^6 M_sun. The best-fit model is close to isotropic inside a radius of about 10 arcmin and becomes increasingly tangentially anisotropic in the outer region, which displays significant mean rotation. This phase-space structure may well be caused by the effects of the tidal field of the Milky Way. The cluster contains a separate disk-like component in the radial range between 1 and 3 arcmin, contributing about 4% to the total mass.Comment: 37 pages (23 figures), accepted for publication in A&A, abstract abridged, for PS and PDF file with full resolution figures, see http://www.strw.leidenuniv.nl/~vdven/oc

General solution of the Jeans equations for triaxial galaxies with separable potentials

The Jeans equations relate the second-order velocity moments to the density and potential of a stellar system. For general three-dimensional stellar systems, there are three equations and six independent moments. By assuming that the potential is triaxial and of separable Staeckel form, the mixed moments vanish in confocal ellipsoidal coordinates. Consequently, the three Jeans equations and three remaining non-vanishing moments form a closed system of three highly-symmetric coupled first-order partial differential equations in three variables. These equations were first derived by Lynden-Bell, over 40 years ago, but have resisted solution by standard methods. We present the general solution here. We consider the two-dimensional limiting cases first. We solve their Jeans equations by a new method which superposes singular solutions. The singular solutions, which are new, are standard Riemann-Green functions. The two-dimensional solutions are applied to non-axisymmetric discs, oblate and prolate spheroids, and also to the scale-free triaxial limit. We then extend the method of singular solutions to the triaxial case, and obtain a full solution. The general solution can be expressed in terms of complete (hyper)elliptic integrals which can be evaluated in a straightforward way, and provides the full set of second moments which can support a triaxial density distribution in a separable triaxial potential. (abridged)Comment: 28 pages (7 figures), LaTeX MN2e, accepted for publication in MNRA

Systemic lupus during pregnancy with refractory alveolar haemorrhage: recovery following termination of pregnancy

A case of refractory pulmonary hemorrhage in a pregnant 22-year-old with systemic lupus is presented. The clinical difficulty of management of pulmonary haemorrhage and lupus flare during pregnancy are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68549/2/10.1177_096120339700600909.pd

Formation of central massive objects via tidal compression

For a density that is not too sharply peaked towards the center, the local tidal field becomes compressive in all three directions. Available gas can then collapse and form a cluster of stars in the center, including or even being dominated by a central black hole. We show that for a wide range of (deprojected) Sersic profiles in a spherical potential, the tidal forces are compressive within a region which encloses most of the corresponding light of observed nuclear clusters in both late-type and early-type galaxies. In such models, tidal forces become disruptive nearly everywhere for relatively large Sersic indices n >= 3.5. We also show that the mass of a central massive object (CMO) required to remove all radial compressive tidal forces scales linearly with the mass of the host galaxy. If CMOs formed in (progenitor) galaxies with n ~ 1, we predict a mass fraction of ~ 0.1-0.5%, consistent with observations of nuclear clusters and super-massive black holes. While we find that tidal compression possibly drives the formation of CMOs in galaxies, beyond the central regions and on larger scales in clusters disruptive tidal forces might contribute to prevent gas from cooling.Comment: 19 pages, 4 figures. Accepted for publication in ApJ. High resolution version available at http://www-obs.univ-lyon1.fr/labo/perso/eric.emsellem/preprint

22: Ex-vivo expansion (EvE) of previously cryopreserved cord blood (CB) into natural killer (NK) cells with enhanced AML and neuroblastoma cytotoxicity Potential role of CB NK cells in adoptive cellular immunotherapy (ACI)

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A study of rotating globular clusters - the case of the old, metal-poor globular cluster NGC 4372

Aims: We present the first in-depth study of the kinematic properties and derive the structural parameters of NGC 4372 based on the fit of a Plummer profile and a rotating, physical model. We explore the link between internal rotation to different cluster properties and together with similar studies of more GCs, we put these in the context of globular cluster formation and evolution. Methods: We present radial velocities for 131 cluster member stars measured from high-resolution FLAMES/GIRAFFE observations. Their membership to the GC is additionally confirmed from precise metallicity estimates. Using this kinematic data set we build a velocity dispersion profile and a systemic rotation curve. Additionally, we obtain an elliptical number density profile of NGC 4372 based on optical images using a MCMC fitting algorithm. From this we derive the cluster's half-light radius and ellipticity as r_h=3.4'+/-0.04' and e=0.08+/-0.01. Finally, we give a physical interpretation of the observed morphological and kinematic properties of this GC by fitting an axisymmetric, differentially rotating, dynamical model. Results: Our results show that NGC 4372 has an unusually high ratio of rotation amplitude to velocity dispersion (1.2 vs. 4.5 km/s) for its metallicity. This, however, puts it in line with two other exceptional, very metal-poor GCs - M 15 and NGC 4590. We also find a mild flattening of NGC 4372 in the direction of its rotation. Given its old age, this suggests that the flattening is indeed caused by the systemic rotation rather than tidal interactions with the Galaxy. Additionally, we estimate the dynamical mass of the GC M_dyn=2.0+/-0.5 x 10^5 M_Sun based on the dynamical model, which constrains the mass-to-light ratio of NGC 4372 between 1.4 and 2.3 M_Sun/L_Sun, representative of an old, purely stellar population.Comment: Accepted for publication in A&A, 12 pages, 14 figures, 2 table