46 research outputs found
New developments in the pathology of malignant lymphoma: a review of the literature published from May to July 2008
Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first century
The Social Position and Intellectual Identity of the Renaissance Mathematician-Physicist Giovanni Battista Benedetti: A Case Study in the Socio-Political History of Mechanics
Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimerâs Disease
Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications
Trends in net survival from head and neck cancer in six European Latin countries: results from the SUDCAN population-based study
Nonsurgical therapies for resected and unresected pancreatic cancer in Europe and USA in 2003â2014: a large international population-based study
The role of chemotherapy in the treatment of pancreatic cancer (PaC) has been well-established, while radiation plays ambiguous roles. This international large-scale population-based study aimed to investigate the real-world application of chemotherapy and radiotherapy for resected and unresected PaC in Europe and USA. Population-based data from multiple European national cancer registries and the US Surveillance, Epidemiology and End Results (SEER)-18 database during 2003â2014 were analyzed. Temporal trends and geographical variations in the application rates of chemotherapy and radiotherapy were quantified using age standardization. Associations of treatment with demographic and clinical characteristics were assessed using multivariable logistic regression. A total of 141,533 PaC patients were analyzed. From 2003â2005 to 2012â2014, chemotherapy administration rates increased in most countries and more strongly among resected patients, while radiation rates were generally low with a slight decline or no obvious trend. In 2012â2014, 12.5% (Estonia) to 61.7% (Belgium) of resected and 17.1% (Slovenia) to 56.9% (Belgium) of unresected patients received chemotherapy. Radiation was administered in 2.6% (Netherlands) to 32.6% (USA) of resected and 1.0% (USA) to 6.0% (Belgium) of unresected patients. Strong temporal and geographical variations were observed. Patterns and strengths of associations of treatment administration with various demographic and clinical factors differed substantially between resected and unresected cancers and varied greatly across countries. Conclusively, administration of chemotherapy but not radiotherapy for PaC increased during the last decade in Europe and USA. Treatment rates were low and the uptake strongly varied across countries, highlighting the need for standardization in PaC treatment to improve patient care