Wetenschapper in wonderland : onderzoek in geuren en kleuren

Coördinatie bio-anorganische chemi

Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacI-galR family of regulatory genes

malR of Strepomyces coelicolor A3(2) encodes a homologue of the Lacl/Galr family of repressor proteins, and is divergently transcribed from the malEFG gene cluster, which encodes components of an ATP-dependent transport system that is required for maltose utilization. Transcription of malE was induced by maltose and repressed by glucose. Disruption or deletion of malR resulted in constitutive, glucose-insensitive malE transcription at a level markedly above that observed in the parental malR+ strain, and overproduction of MalR prevented growth on maltose as carbon source. Consequently, MalR plays a crucial role in both substrate induction and glucose repression of maltose utilization. MalR is expressed from a single promoter with transcription initiating at the first G of the predicted GTG translataion start codon

Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?

Microbial Biotechnolog

Off the wall

Microbial Biotechnolog

Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow

Article / Letter to editorInstituut Biologie Leide

Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow

Article / Letter to editorInstituut Biologie Leide

Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow

Article / Letter to editorInstituut Biologie Leide

Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow

Article / Letter to editorInstituut Biologie Leide

Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow

Article / Letter to editorInstituut Biologie Leide

Morphogenesis of streptomyces in submerged cultures

Microbial Biotechnolog