1,896 research outputs found
Self-Pulsating Semiconductor Lasers: Theory and Experiment
We report detailed measurements of the pump-current dependency of the
self-pulsating frequency of semiconductor CD lasers. A distinct kink in this
dependence is found and explained using rate-equation model. The kink denotes a
transition between a region where the self-pulsations are weakly sustained
relaxation oscillations and a region where Q-switching takes place. Simulations
show that spontaneous emission noise plays a crucial role for the cross-over.Comment: Revtex, 16 pages, 7 figure
First order phase transition in a nonequilibrium growth process
We introduce a simple continuous model for nonequilibrium surface growth. The
dynamics of the system is defined by the KPZ equation with a Morse-like
potential representing a short range interaction between the surface and the
substrate. The mean field solution displays a non trivial phase diagram with a
first order transition between a growing and a bound surface, associated with a
region of coexisting phases, and a tricritical point where the transition
becomes second order. Numerical simulations in 3 dimensions show quantitative
agreement with mean field results, and the features of the phase space are
preserved even in 2 dimensions.Comment: 7 figures, revtex, submitted to Phys. Rev.
Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: An overview of systematic reviews
Background: Antibiotic resistance is a worldwide health threat. Interventions that reduce antibiotic prescribing by clinicians are expected to reduce antibiotic resistance. Disparate interventions to change antibiotic prescribing behaviour for acute respiratory infections (ARIs) have been trialled and meta-analysed, but not yet synthesised in an overview. This overview synthesises evidence from systematic reviews, rather than individual trials. Objectives: To systematically review the existing evidence from systematic reviews on the effects of interventions aimed at influencing clinician antibiotic prescribing behaviour for ARIs in primary care. Methods: We searched the Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (DARE), MEDLINE, Embase, CINAHL, PsycINFO, and Science Citation Index to June 2016. We also searched the reference lists of all included reviews. We ran a pre-publication search in May 2017 and placed additional studies in 'awaiting classification'. We included both Cochrane and non-Cochrane reviews of randomised controlled trials evaluating the effect of any clinician-focussed intervention on antibiotic prescribing behaviour in primary care. Two overview authors independently extracted data and assessed the methodological quality of included reviews using the ROBIS tool, with disagreements reached by consensus or by discussion with a third overview author. We used the GRADE system to assess the quality of evidence in included reviews. The results are presented as a narrative overview. Main results: We included eight reviews in this overview: five Cochrane Reviews (33 included trials) and three non-Cochrane reviews (11 included trials). Three reviews (all Cochrane Reviews) scored low risk across all the ROBIS domains in Phase 2 and low risk of bias overall. The remaining five reviews scored high risk on Domain 4 of Phase 2 because the 'Risk of bias' assessment had not been specifically considered and discussed in the review Results and Conclusions. The trials included in the reviews varied in both size and risk of bias. Interventions were compared to usual care. Moderate-quality evidence indicated that C-reactive protein (CRP) point-of-care testing (risk ratio (RR) 0.78, 95% confidence interval (CI) 0.66 to 0.92, 3284 participants, 6 trials), shared decision making (odds ratio (OR) 0.44, 95% CI 0.26 to 0.75, 3274 participants, 3 trials; RR 0.64, 95% CI 0.49 to 0.84, 4623 participants, 2 trials; risk difference -18.44, 95% CI -27.24 to -9.65, 481,807 participants, 4 trials), and procalcitonin-guided management (adjusted OR 0.10, 95% CI 0.07 to 0.14, 1008 participants, 2 trials) probably reduce antibiotic prescribing in general practice. We found moderate-quality evidence that procalcitonin-guided management probably reduces antibiotic prescribing in emergency departments (adjusted OR 0.34, 95% CI 0.28 to 0.43, 2605 participants, 7 trials). The overall effect of these interventions was small (few achieving greater than 50% reduction in antibiotic prescribing, most about a quarter or less), but likely to be clinically important. Compared to usual care, shared decision making probably makes little or no difference to reconsultation for the same illness (RR 0.87, 95% CI 0.74 to 1.03, 1860 participants, 4 trials, moderate-quality evidence), and may make little or no difference to patient satisfaction (RR 0.86, 95% CI 0.57 to 1.30, 1110 participants, 2 trials, low-quality evidence). Similarly, CRP testing probably has little or no effect on patient satisfaction (RR 0.79, 95% CI 0.57 to 1.08, 689 participants, 2 trials, moderate-quality evidence) or reconsultation (RR 1.08, 95% CI 0.93 to 1.27, 5132 participants, 4 trials, moderate-quality evidence). Procalcitonin-guided management probably results in little or no difference in treatment failure in general practice compared to normal care (adjusted OR 0.95, 95% CI 0.73 to 1.24, 1008 participants, 2 trials, moderate-quality evidence), however it probably reduces treatment failure in the emergency department compared to usual care (adjusted OR 0.76, 95% CI 0.61 to 0.95, 2605 participants, 7 trials, moderate-quality evidence). The quality of evidence for interventions focused on clinician educational materials and decision support in reducing antibiotic prescribing in general practice was either low or very low (no pooled result reported) and trial results were highly heterogeneous, therefore we were unable draw conclusions about the effects of these interventions. The use of rapid viral diagnostics in emergency departments may have little or no effect on antibiotic prescribing (RR 0.86, 95% CI 0.61 to 1.22, 891 participants, 3 trials, low-quality evidence) and may result in little to no difference in reconsultation (RR 0.86, 95% CI 0.59 to 1.25, 200 participants, 1 trial, low-quality evidence). None of the trials in the included reviews reported on management costs for the treatment of an ARI or any associated complications. Authors' conclusions: We found evidence that CRP testing, shared decision making, and procalcitonin-guided management reduce antibiotic prescribing for patients with ARIs in primary care. These interventions may therefore reduce overall antibiotic consumption and consequently antibiotic resistance. There do not appear to be negative effects of these interventions on the outcomes of patient satisfaction and reconsultation, although there was limited measurement of these outcomes in the trials. This should be rectified in future trials. We could gather no information about the costs of management, and this along with the paucity of measurements meant that it was difficult to weigh the benefits and costs of implementing these interventions in practice. Most of this research was undertaken in high-income countries, and it may not generalise to other settings. The quality of evidence for the interventions of educational materials and tools for patients and clinicians was either low or very low, which prevented us from drawing any conclusions. High-quality trials are needed to further investigate these interventions. </p
Discovering duplicate tasks in transition systems for the simplification of process models
This work presents a set of methods to improve the understandability of process models. Traditionally, simplification methods trade off quality metrics, such as fitness or precision. Conversely, the methods proposed in this paper produce simplified models while preserving or even increasing fidelity metrics. The first problem addressed in the
paper is the discovery of duplicate tasks. A new method is proposed that avoids overfitting by working on the transition system generated by the log. The method is able to discover duplicate tasks even in the presence of concurrency and choice. The second problem is the structural simplification of the model by identifying optional and repetitive tasks. The tasks are substituted by annotated events that allow the removal of silent tasks and reduce the complexity of the
model. An important feature of the methods proposed in this paper is that they are independent from the actual miner used for process discovery.Peer ReviewedPostprint (author's final draft
Multiple Front Propagation Into Unstable States
The dynamics of transient patterns formed by front propagation in extended
nonequilibrium systems is considered. Under certain circumstances, the state
left behind a front propagating into an unstable homogeneous state can be an
unstable periodic pattern. It is found by a numerical solution of a model of
the Fr\'eedericksz transition in nematic liquid crystals that the mechanism of
decay of such periodic unstable states is the propagation of a second front
which replaces the unstable pattern by a another unstable periodic state with
larger wavelength. The speed of this second front and the periodicity of the
new state are analytically calculated with a generalization of the marginal
stability formalism suited to the study of front propagation into periodic
unstable states. PACS: 47.20.Ky, 03.40.Kf, 47.54.+rComment: 12 page
Noise induced transition from an absorbing phase to a regime of stochastic spatiotemporal intermittency
We introduce a stochastic partial differential equation capable of
reproducing the main features of spatiotemporal intermittency (STI).
Additionally the model displays a noise induced transition from laminarity to
the STI regime. We show by numerical simulations and a mean-field analysis that
for high noise intensities the system globally evolves to a uniform absorbing
phase, while for noise intensities below a critical value spatiotemporal
intermittence dominates. A quantitative computation of the loci of this
transition in the relevant parameter space is presented.Comment: 4 pages, 6 eps figures. Submitted to Phys. Rev. Lett. See for
additional information http://imedea.uib.es
Recent results on multiplicative noise
Recent developments in the analysis of Langevin equations with multiplicative
noise (MN) are reported. In particular, we:
(i) present numerical simulations in three dimensions showing that the MN
equation exhibits, like the Kardar-Parisi-Zhang (KPZ) equation both a weak
coupling fixed point and a strong coupling phase, supporting the proposed
relation between MN and KPZ;
(ii) present dimensional, and mean field analysis of the MN equation to
compute critical exponents;
(iii) show that the phenomenon of the noise induced ordering transition
associated with the MN equation appears only in the Stratonovich representation
and not in the Ito one, and
(iv) report the presence of a new first-order like phase transition at zero
spatial coupling, supporting the fact that this is the minimum model for noise
induced ordering transitions.Comment: Some improvements respect to the first versio
Dynamics of localized structures in vector waves
Dynamical properties of topological defects in a twodimensional complex
vector field are considered. These objects naturally arise in the study of
polarized transverse light waves. Dynamics is modeled by a Vector Complex
Ginzburg-Landau Equation with parameter values appropriate for linearly
polarized laser emission. Creation and annihilation processes, and
selforganization of defects in lattice structures, are described. We find
"glassy" configurations dominated by vectorial defects and a melting process
associated to topological-charge unbinding.Comment: 4 pages, 5 figures included in the text. To appear in Phys. Rev.
Lett. (2000). Related material at http://www.imedea.uib.es/Nonlinear and
http://www.imedea.uib.es/Photonics . In this new version, Fig. 3 has been
replaced by a better on
Winding number instability in the phase-turbulence regime of the Complex Ginzburg-Landau Equation
We give a statistical characterization of states with nonzero winding number
in the Phase Turbulence (PT) regime of the one-dimensional Complex
Ginzburg-Landau equation. We find that states with winding number larger than a
critical one are unstable, in the sense that they decay to states with smaller
winding number. The transition from Phase to Defect Turbulence is interpreted
as an ergodicity breaking transition which occurs when the range of stable
winding numbers vanishes. Asymptotically stable states which are not
spatio-temporally chaotic are described within the PT regime of nonzero winding
number.Comment: 4 pages,REVTeX, including 4 Figures. Latex (or postscript) version
with figures available at http://formentor.uib.es/~montagne/textos/nupt
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