Thomas Aquinas on the Sacrifice of Christ and the Eucharist: A Defence

In this paper I will discuss one of the soteriological models Thomas Aquinas outlines in his Summa Theologiae, namely ‘sacrifice’. This is only one of several, but not mutually exclusive, ways in which Thomas interprets our salvation in Christ. I will briefly list the other models before focussing in more depth on sacrifice by considering some objections against it. I will continue by outlining Thomas's theology of sacrifice in its own right and explain its connections with the Eucharist. By way of conclusion I will return to the modern criticism raised

Contemplation, Intellectus, and Simplex Intuitus in Aquinas: Recovering a Neoplatonic Theme

This contribution examines two related points in relation to Aquinas’s understanding of contemplation, which is a sorely neglected topic in scholarship. First, after having outlined that the final act of contemplation culminates in an intellective, simple apprehension of the truth, I will examine how this act relates to the three operations of the intellect (grasping of quiddity, judgement, and reasoning) Aquinas identifies in a number of places. Second, I argue that his view of contemplation as simple insight is significantly indebted to Neoplatonic sources; therefore, we must pay attention to the way he introduces Neoplatonic elements into his Aristotelian framework. I conclude this contribution by suggesting some reasons—of a theological nature—why Aquinas would have been drawn towards a non-discursive or “intuitive” notion of contemplation

Homozygous DBF4 mutation as a cause for severe congenital neutropenia

Background Severe congenital neutropenia presents with recurrent infections early in life due to arrested granulopoiesis. Multiple genetic defects are known to block granulocyte differentiation, however a genetic cause remains unknown in approximately 40% of cases. Objective We aimed to characterize a patient with severe congenital neutropenia and syndromic features without a genetic diagnosis. METHODS: Whole exome sequencing results were validated using flow cytometry, Western blotting, co-immunoprecipitation, quantitative PCR, cell cycle and proliferation analysis of lymphocytes and fibroblasts and granulocytic differentiation of primary CD34+ and HL-60 cells. Results We identified a homozygous missense mutation in DBF4 in a patient with mild extra-uterine growth retardation, facial dysmorphism and severe congenital neutropenia. DBF4 is the regulatory subunit of the CDC7 kinase, together known as DBF4-dependent kinase (DDK), the complex essential for DNA replication initiation. The variant allele demonstrated impaired ability to bind CDC7, resulting in decreased DDK-mediated phosphorylation, defective S phase entry and progression and impaired differentiation of granulocytes associated with activation of the p53-p21 pathway. The introduction of WT DBF4 into patient CD34+ cells rescued the promyelocyte differentiation arrest. Conclusion Hypomorphic DBF4 mutation causes autosomal recessive severe congenital neutropenia with syndromic features

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patients suffer from episodes of life-threatening necrosis, typically triggered by S. aureus infection. The disorder is phenocopied in patients with the 5p- (Cri-du-Chat) chromosomal deletion syndrome. OTULIN haploinsufficiency causes an accumulation of linear ubiquitin in dermal fibroblasts, but tumor necrosis factor receptor-mediated nuclear factor kappa B signaling remains intact. Blood leukocyte subsets are unaffected. The OTULIN-dependent accumulation of caveolin-1 in dermal fibroblasts, but not leukocytes, facilitates the cytotoxic damage inflicted by the staphylococcal virulence factor alpha-toxin. Naturally elicited antibodies against alpha-toxin contribute to incomplete clinical penetrance. Human OTULIN haploinsufficiency underlies life-threatening staphylococcal disease by disrupting cell-intrinsic immunity to alpha-toxin in nonleukocytic cells.Peer reviewe

Introduction to Medieval Theology: Second Edition

This classic book, now in a second, expanded edition, is an invitation to think along with major theologians and spiritual authors, men and women from the time of St Augustine to the end of the fourteenth century, who profoundly challenge our (post-)modern assumptions. Medieval theology was radically theocentric, Trinitarian, Scriptural, and sacramental, yet it also operated with a rich notion of human understanding. In a post-modern setting, when modern views on 'autonomous reason' are increasingly questioned, it is fruitful to re-engage with pre-modern thinkers who did not share our modern and post-modern presuppositions. Their different perspective does not antiquate their thought; on the contrary, it makes them profoundly challenging and enriching for theology today. This survey introduces readers to key theologians of the period and explores themes of the relationship between faith and reason; the mystery of the Trinity; soteriology; Christian love; and the transcendent thrust of medieval thought

Trinitarian Indwelling

This chapter discusses two models of the Trinity: the so-called social or interpersonal model, and the psychological or intrapersonal model. How we conceive of the indwelling of the Trinity will be determined by the extent to which we espouse one of these models. The chapter argues that the social model, although rather fashionable in current theology, may not be as suitable as the intrapersonal model to account for the indwelling in the soul of the divine Persons and the Son in particular. The intrapersonal model, on the other hand, can account for a genuine indwelling of both the Son and Holy Spirit

Ruusbroec, Jordaens, and Herp on the Common Life: the Transformation of a Spiritual Ideal

Towards the end of the second book of Espousals, Ruusbroec reminds his readers that 'enjoyment and activity constitute the blessedness of Christ and all his saints'. This is one of the many places in which he expresses one of the distinguishing features of the medieval spirituality of the Low Countries, namely, the spiritual ideal in which activity and rest are in perfect harmony with one another. Ruusbroec's 'common life' is perhaps the best known exponent of this ideal. Willem Jordaens retains the notion of the common life. In author's view Hendrik Herp failed to do full justice to a quintessential aspect of Ruusbroec's mystical theology: he does not adopt Ruusbroec's notion of regiratio of the Holy Spirit and how it grounds his ideal of the common life, which is probably why later French and Spanish authors do not adopt this important aspect of Ruusbroec's doctrine either