James Joyce and the Middlebrow

James Joyce and the Middlebro

Indexing the Buffalo Notebooks: genetic criticism and the construction of evidence

Indexing the Buffalo Notebooks: genetic criticism and the construction of evidenc

Annotation and commentary in the modernist edition: a critique

Annotation and commentary have been little considered in discussions about scholarly editing, despite being some of the most used segments of the scholarly edition. What treatments do exist mostly focus on practical aspects about the quality and style of annotation. This essay analyses some of the theoretical assumptions that underlie annotational practices with specific reference to the editing of modernist works. It puts into question, first of all, some common perceptions about annotation, which is sometimes viewed as interfering with the readerly experience, to address the matter of the reader: what kind of reader are annotations for? Because annotations are a contextual and hermeneutic device to bridge the gap between the literary work that has come to us from the past and the reader’s present, not all readers are served by a single style of annotation. Conversely, to accept this hermeneutic value also means that annotation is never neutral or objective; while editorial practices tend to avoid open interpretive annotation, annotations nonetheless direct the process of reading and interpretation. Annotation thus participates in the sense-making process and, like all other editorial interventions, it represents an act of mediation

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Introduction

This is the introduction to the edition of the manuscript materials for Where There is Nothing and The Unicorn from the stars, two version of a play co-written by W.B. Yeats and Lady Augusta Gregory between 1902 and 1907, based on an early idea by George Moore. It contains a detailed survey of the composition history and their earliest publication of the play texts, as well as a assesment of the co-authorship between Yeats and Lady Gregory. A Census of the extant manuscripts and typescripts is appended

Reading Joyce in and out of the Archive

This essay contains a critical overview of responses to the 'scholarship' (by which is meant the study of the manuscripts and notebooks, the writing of biographical, the editing of his texts, the amalgamation of annotations, etc.) as opposed to 'criticism' of Joyce's later works. It argues for a greater textual awareness in the critical study of his writings.This is a pre-copyedited version of an article accepted for publication in the 'Joyce Studies Annual' following peer review. The definitive publisher-authenticated version is available through the University of Texas Press

Reflections on Textual Editing in the Time of the History of the Book

This article expresses the need for an approach to scholarly editing that is more historically rooted than has hitherto been the case in Anglo-American textual criticism. It gives a new understanding of what has happened in the field since the “sociological turn” since J. J. McGann and D. F. McKenzie and argues for a realignment between text and the material forms of the book, and for scholarly editors to pay closer attention to the granularity of the texts that have come down to us from the past

“I have met you too late”: James Joyce, W.B. Yeats and the Making of Chamber Music

A consideration of the early relationship between James Joyce and W.B. Yeats and the literary-historical contexts of the composition, publication and reception of Chamber Music