3 research outputs found
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΡΡΠ΅ΡΠΈΠ½ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΌΠ°ΡΡΠΈΠ²Π΅ ΠΏΡΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ Π΅Π³ΠΎ Π³Π°Π·ΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΎΠΉ
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠ΄Π΅ΡΠΆΠΈΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π° ΡΠ³Π»Ρ ΠΈΠ· ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ
Π² ΡΡΠ°Π΄ΠΈΡ Π±ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·ΡΡΡΠ΅Π½ΠΈΡ. ΠΠΉ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΠΊ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΠΈΡΡΡ. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½ΠΎ ΡΠ»Π°Π²Π»ΠΈΠ²Π°ΡΡ ΡΡΠΎΡ ΠΌΠΎΠΌΠ΅Π½Ρ ΡΡΠ΅Π΄ΠΈ ΠΌΠ°ΡΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΎΡΠΊΠ»ΠΈΠΊΠΎΠ² ΠΌΠ°ΡΡΠΈΠ²Π° Π½Π° Π²Π΅Π΄Π΅Π½ΠΈΠ΅ Π³ΠΎΡΠ½ΡΡ
ΡΠ°Π±ΠΎΡ. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΈ ΡΠ΅Π»Π°ΠΊΡΠ°ΡΠΈΠ΅ΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΡΡΠ΅ΡΠΈΠ½ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ°.The inhibition process of coal transition from the potentially stable state in the stage of stormy destruction is investigation. As a rule, to it is preceded some interval of relative time calm. It
is especially important to catch this moment among mass of different responses of array on the
conduct of mountain works. Physical and chemical treatment can serve as one of control variants
the development and relaxation of the cracks system
Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats
It is well known that bacterial lipopolysaccharides (LPS) both increases proinflammatory cytokines and produces sickness behavior, including fatigue and anhedonia (i.e., the inability to experience pleasure). Previously, we have shown that intraperitoneally (i.p.) administered LPS increased extracellular monoamine metabolite levels in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC), which was completely, or at least partly, prevented by pretreatment with a triple reuptake inhibitor that also blocks the serotonin (5-HT) transporter (SERT). This suggests indirectly, that LPS may enhance SERT transporter activity, and consequently, increase removal of 5-HT from the synaptic cleft, and increase metabolism of 5-HT. In the present study, we focus more specifically on the role of SERT in this increased metabolism by using rats, that differ in SERT expression. Therefore, the effects of an intraperitoneal LPS injection on extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were investigated by in vivo microdialysis in the NAc and mPFC of wild type (SERT+/+), heterozygous (SERT+/−) and knockout (SERT−/−) rats. Here, we show that LPS-induced 5-HIAA formation in male rats, is significantly increased in SERT+/+ rats in both the NAc and mPFC, whereas this increase is partly or totally abolished in SERT+/− and SERT−/− rats, respectively. Thus, the present study supports the hypothesis that systemic LPS in male rats increases SERT function and consequently enhances 5-HT uptake and metabolism in both the NAc and mPFC