Stofreductie in kuikenstal dankzij oliefilm

Stof in de stal is al jarenlang een aandachtspunt uit oogpunt van arbo en diergezondheid. De laatste jaren is daar de emissie van fijnstof naar de buitenlucht bijgekomen, aangezien de EU normen heeft gesteld voor maximale concentraties fijnstof in de buitenlucht. Er zijn normen gesteld voor deeltjes kleiner dan 10 micrometer (PM10) en voor deeltjes kleiner dan 2,5 micrometer (PM2.5). De veehouderij draagt naast verkeer en industrie bij aan de emissie van fijnstof. Het merendeel van het fijnstof uit de veehouderij komt uit pluimvee- en varkensstalle

Reductie stofemissie bij vleeskuikens door aanbrengen oliefilm = Reduction of dust emission from broilers by application of an oil film

The effect of application of an oil film on bedding on dust reduction in a broiler house was studied. The system proved to be effectiv

Oral health and childhood stress during the Final Neolithic in Grotte de la Faucille (Sclayn, BE)

Grotte de la Faucille is one of many collective cave burials in the Belgian Meuse Basin. This study is an inventory and dental analysis of the ± 300 human teeth recovered from the cave. The aim is to gain further insights into oral health, childhood stress, subsistence, and diet in Neolithic Belgium. Grotte de la Faucille is one of a few recently excavated sites and is unique in the detailed study of its chronology. This study found high caries and enamel defect rates compared to other studies of Neolithic teeth from Belgium. However, rates correspond with those from other Neolithic societies in Europe. This study provides valuable new insights into the Neolithic people of Belgium from a dental anthropological perspective and may function as a reference for future intrapopulation studies

Innovatieve dijken als strategie voor een veilig en aantrekkelijk Waddengebied : Samenvatting van het Deltaprogramma Waddengebied onderzoek naar innovatieve dijken

In opdracht van het Deltaprogramma Waddengebied zijn diverse studies uitgevoerd naar de kansen voor innovatieve dijkconcepten in het Waddengebied. Daarbij is de toepasbaarheid en effectiviteit voor de waterveiligheid verkend en is de meerwaarde voor natuur, landschap en recreatie van innovatieve dijkconcepten in het Waddengebied in beeld gebracht. In dit rapport worden de belangrijkste bevindingen uit deze studies samengevat met als doel de state of the art kennis en inzichten rond innovatieve dijkconcepten in het Waddengebied te schetsen

Sampling and contaminant monitoring protocol for raptors

In May 2013 representatives from six countries gathered in Murcia, Spain, to attend the Workshop on &ldquo;Setting best practices on raptor contaminant monitoring activities in Europe&rdquo; funded by EURAPMON. The workshop developed a rough draft of the current protocol. The protocol was subsequently completed with the involvement of investigators from Belgium, Denmark, France, Germany, The Netherlands, Norway, Spain, Sweden and the United Kingdom. All contributors are experts in monitoring contaminants in raptors. The aim of this sampling protocol is to provide guidance on types of best practice that will facilitate harmonisation of procedures between existing and emerging schemes and so maximise the reliability, comparability and interoperability of data.The methods here do not require use of anaesthesia on birds. This protocol covers the sampling of blood and feathers from live birds, addled and deserted eggs, internal organs and tissues from dead specimens, and other samples such as faeces, preen oil and pellets.</p

Protocol for a prospective, longitudinal cohort study on the effect of arterial disease level on the outcomes of supervised exercise in intermittent claudication: the ELECT Registry

Introduction Despite guideline recommendations advocating conservative management before invasive treatment in intermittent claudication, early revascularisation remains widespread in patients with favourable anatomy. The aim of the Effect of Disease Level on Outcomes of Supervised Exercise in Intermittent Claudication Registry is to determine the effect of the location of stenosis on the outcomes of supervised exercise in patients with intermittent claudication due to peripheral arterial disease. Methods and analysis This multicentre prospective cohort study aims to enrol 320 patients in 10 vascular centres across the Netherlands. All patients diagnosed with intermittent claudication (peripheral arterial disease: Fontaine II/Rutherford 1–3), who are considered candidates for supervised exercise therapy by their own physicians are appropriate to participate. Participants will receive standard care, meaning supervised exercise therapy first, with endovascular or open revascularisation in case of insufficient effect (at the discretion of patient a

Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity

DX-8951f (exatecan mesylate), a new water-soluble derivative of camptothecin, is currently being evaluated in phase II clinical trials. Resistance may be acquired when treating cancer patients with DX-8951f. Therefore, we selected a subline of the human ovarian cancer cell line A2780 for resistance against DX-8951f to investigate possible mechanisms of resistance. This DX-8951f-resistant subline, designated 2780DX8 (resistance factor=9.3), displayed a typical cross-resistance pattern including compounds, such as topotecan (resistance factor =34), SN-38 (resistance factor =47), mitoxantrone (resistance factor =59) and doxorubicin (resistance factor =2.9), which have previously been associated with the expression of breast cancer resistance protein. 2780DX8 cells did not show changes in the topoisomerase I gene, in topoisomerase I protein levels or catalytic activity. Overexpression of breast cancer resistance protein could be detected, both at the mRNA and protein level, while staining for Pgp, MRP1, or LRP was negative. GF120918, an inhibitor of breast cancer resistance protein, was able to reverse the DX-8951f-induced resistance in 2780DX8 cells. In vivo experiments in well-established 2780DX8 human tumour xenografts demonstrated that the growth inhibition induced by CPT-11 was more affected by breast cancer resistance protein expression than that of DX-8951f. These data indicate for the first time that DX-8951f is able to induce breast cancer resistance protein as a mechanism of resistance. Breast cancer resistance protein, however, results in only minor reduction of antitumour activity of DX-8951f which is an advantage over topotecan and CPT-11/SN-38