419 research outputs found
Drug Repurposing for Rare Diseases
Currently, there are about 7000 identified rare diseases, together affecting 10% of the population. However, fewer than 6% of all rare diseases have an approved treatment option, highlighting their tremendous unmet needs in drug development. The process of repurposing drugs for new indications, compared with the development of novel orphan drugs, is a time-saving and cost-efficient method resulting in higher success rates, which can therefore drastically reduce the risk of drug development for rare diseases. Although drug repurposing is not novel, new strategies have been developed in recent years to do it in a systematic and rational way. Here, we review applied methodologies, recent accomplished progress, and the challenges associated in drug repurposing for rare diseases
Hemihepatectomy and Replacement of The Afferent Hepatic Blood Supply in The Dog
Hemihepatectomy along with portal vein or hepatic artery replacement in dogs was well tolerated, but
combined with replacement of both vessels it was lethal because of outflow block and shock. Total liver
blood flow should be kept as high as possible during such procedures in man
Nautisch erfgoed in het (zuidelijke) deel van de Noordzee onder toezicht van België: een analyse
Archeologische prospectie met ingreep in de bodem. Vaargeul Boven-Zeeschelde. Baasrode-Fabriek & Mariekerke. (archeologische vergunning 2016/312). Eindrapport (inclusief aanbevelingen).
Erfgoed in zee: wat moet ik ermee? Richtlijnen voor de gebruikers van de Noordzee met betrekking tot het cultureel erfgoed onder water
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