925 research outputs found

    PMD5 VALUATION OF NEW DRUG APPLICATIONS OF PHARMACEUTICAL COMPANIES USING COMPOUND OPTION MODELS

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    The Halo Mass of Optically Luminous Quasars at z ,F≈ ,F1-2 Measured via Gravitational Deflection of the Cosmic Microwave Background

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    © 2019. The American Astronomical Society. All rights reserved.We measure the average deflection of cosmic microwave background photons by quasars at 〈Z〉= 1.7. Our sample is selected from the Sloan Digital Sky Survey to cover the redshift range 0.9 ≤z≤2.2 with absolute i-band magnitudes of M i ≤-24 (K-corrected to z = 2). A stack of nearly 200,000 targets reveals an 8δ detection of Planck's estimate of the lensing convergence toward the quasars. We fit the signal with a model comprising a Navarro-Frenk-White density profile and a two-halo term accounting for correlated large-scale structure, which dominates the observed signal. The best-fitting model is described by an average halo mass log 10 (M h h -1 M)12.6 ±0.2 = and linear bias b=2.7±0.3 at 〈Z 〉= 1.7, in excellent agreement with clustering studies. We also report a hint, at a 90% confidence level, of a correlation between the convergence amplitude and luminosity, indicating that quasars brighter than Mi≲ -26 reside in halos of typical mass M h ≈ 10 13 h -1 M, scaling roughly as M h ∞ L opt 3/4 at M i ≲-24 mag, in good agreement with physically motivated quasar demography models. Although we acknowledge that this luminosity dependence is a marginal result, the observed Mh-L opt relationship could be interpreted as a reflection of the cutoff in the distribution of black hole accretion rates toward high Eddington ratios: the weak trend of Mh with Lopt observed at low luminosity becomes stronger for the most powerful quasars, which tend to be accreting close to the Eddington limit.Peer reviewedFinal Accepted Versio

    Survey strategy optimization for the Atacama Cosmology Telescope

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    In recent years there have been significant improvements in the sensitivity and the angular resolution of the instruments dedicated to the observation of the Cosmic Microwave Background (CMB). ACTPol is the first polarization receiver for the Atacama Cosmology Telescope (ACT) and is observing the CMB sky with arcmin resolution over about 2000 sq. deg. Its upgrade, Advanced ACTPol (AdvACT), will observe the CMB in five frequency bands and over a larger area of the sky. We describe the optimization and implementation of the ACTPol and AdvACT surveys. The selection of the observed fields is driven mainly by the science goals, that is, small angular scale CMB measurements, B-mode measurements and cross-correlation studies. For the ACTPol survey we have observed patches of the southern galactic sky with low galactic foreground emissions which were also chosen to maximize the overlap with several galaxy surveys to allow unique cross-correlation studies. A wider field in the northern galactic cap ensured significant additional overlap with the BOSS spectroscopic survey. The exact shapes and footprints of the fields were optimized to achieve uniform coverage and to obtain cross-linked maps by observing the fields with different scan directions. We have maximized the efficiency of the survey by implementing a close to 24 hour observing strategy, switching between daytime and nighttime observing plans and minimizing the telescope idle time. We describe the challenges represented by the survey optimization for the significantly wider area observed by AdvACT, which will observe roughly half of the low-foreground sky. The survey strategies described here may prove useful for planning future ground-based CMB surveys, such as the Simons Observatory and CMB Stage IV surveys.Comment: 14 Pages, 9 Figures, 4 Table

    A Measurement of the Cosmic Microwave Background Damping Tail from the 2500-square-degree SPT-SZ survey

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    We present a measurement of the cosmic microwave background (CMB) temperature power spectrum using data from the recently completed South Pole Telescope Sunyaev-Zel'dovich (SPT-SZ) survey. This measurement is made from observations of 2540 deg2^2 of sky with arcminute resolution at 150150\,GHz, and improves upon previous measurements using the SPT by tripling the sky area. We report CMB temperature anisotropy power over the multipole range 650<<3000650<\ell<3000. We fit the SPT bandpowers, combined with the seven-year Wilkinson Microwave Anisotropy Probe (WMAP7) data, with a six-parameter LCDM cosmological model and find that the two datasets are consistent and well fit by the model. Adding SPT measurements significantly improves LCDM parameter constraints; in particular, the constraint on θs\theta_s tightens by a factor of 2.7. The impact of gravitational lensing is detected at 8.1σ8.1\, \sigma, the most significant detection to date. This sensitivity of the SPT+WMAP7 data to lensing by large-scale structure at low redshifts allows us to constrain the mean curvature of the observable universe with CMB data alone to be Ωk=0.0030.018+0.014\Omega_k=-0.003^{+0.014}_{-0.018}. Using the SPT+WMAP7 data, we measure the spectral index of scalar fluctuations to be ns=0.9623±0.0097n_s=0.9623 \pm 0.0097 in the LCDM model, a 3.9σ3.9\,\sigma preference for a scale-dependent spectrum with ns<1n_s<1. The SPT measurement of the CMB damping tail helps break the degeneracy that exists between the tensor-to-scalar ratio rr and nsn_s in large-scale CMB measurements, leading to an upper limit of r<0.18r<0.18 (95%,C.L.) in the LCDM+rr model. Adding low-redshift measurements of the Hubble constant (H0H_0) and the baryon acoustic oscillation (BAO) feature to the SPT+WMAP7 data leads to further improvements. The combination of SPT+WMAP7+H0H_0+BAO constrains ns=0.9538±0.0081n_s=0.9538 \pm 0.0081 in the LCDM model, a 5.7σ5.7\,\sigma detection of ns<1n_s < 1, ... [abridged]Comment: 21 pages, 10 figures. Replaced with version accepted by ApJ. Data products are available at http://pole.uchicago.edu/public/data/story12

    A Direct Measurement of the Linear Bias of Mid-infrared-selected Quasars at z ap 1 Using Cosmic Microwave Background Lensing

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    We measure the cross-power spectrum of the projected mass density as traced by the convergence of the cosmic microwave background lensing field from the South Pole Telescope (SPT) and a sample of Type 1 and 2 (unobscured and obscured) quasars at langzrang ~ 1 selected with the Wide-field Infrared Survey Explorer, over 2500 deg2. The cross-power spectrum is detected at ≈7σ, and we measure a linear bias b = 1.61 ± 0.22, consistent with clustering analyses. Using an independent lensing map, derived from Planck observations, to measure the cross-spectrum, we find excellent agreement with the SPT analysis. The bias of the combined sample of Type 1 and 2 quasars determined in this work is similar to that previously determined for Type 1 quasars alone; we conclude that obscured and unobscured quasars trace the matter field in a similar way. This result has implications for our understanding of quasar unification and evolution schemes.Peer reviewe

    Подсистема автономного программно-аппаратного комплекса для индуктивного долгосрочного прогноза осредненных значений метеопараметров

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    The research of the inductive method of long-term (forestalling to 0,5 year) prognosis of average decade air s temperature on the basis of principle of analogies was executed and it s sufficient was shown. The research of the offered approach was also conducted: in the base of spatial models without principle of analogies; in the polynomial harmonic base; the analysis of middle quality of the inductive prognostic method for cases of the analogue principle usage and without it

    A CMB lensing mass map and its correlation with the cosmic infrared background

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    We use a temperature map of the cosmic microwave background (CMB) obtained using the South Pole Telescope at 150 GHz to construct a map of the gravitational convergence to z ~ 1100, revealing the fluctuations in the projected mass density. This map shows individual features that are significant at the ~ 4 sigma level, providing the first image of CMB lensing convergence. We cross-correlate this map with Herschel/SPIRE maps covering 90 square degrees at wavelengths of 500, 350, and 250 microns. We show that these submillimeter-wavelength (submm) maps are strongly correlated with the lensing convergence map, with detection significances in each of the three submm bands ranging from 6.7 to 8.8 sigma. We fit the measurement of the cross power spectrum assuming a simple constant bias model and infer bias factors of b=1.3-1.8, with a statistical uncertainty of 15%, depending on the assumed model for the redshift distribution of the dusty galaxies that are contributing to the Herschel/SPIRE maps.Comment: 5 pages, 3 figures, to be submitted to ApJ

    Overexpression of UV-DAMAGED DNA BINDING PROTEIN 1 links plant development and phytonutrient accumulation in high pigment-1 tomato

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    Fruits of tomato plants carrying the high pigment-1 mutations hp-1 and hp-1w are characterized by an increased number of plastids coupled with enhanced levels of functional metabolites. Unfortunately, hp-1 mutant plants are also typified by light-dependent retardation in seedling and whole-plant growth and development, which limits their cultivation. These mutations were mapped to the gene encoding UV-DAMAGED DNA BINDING PROTEIN 1 (DDB1) and, recently, fruit-specific RNA interference studies have demonstrated an increased number of plastids and enhanced carotenoid accumulation in the transgenic tomato fruits. However, whole-plant overexpression of DDB1, required to substantiate its effects on seedling and plant development and to couple them with fruit phenotypes, has heretofore been unsuccessful. In this study, five transgenic lines constitutively overexpressing normal DDB1 in hp-1 mutant plants were analysed. Eleven-day-old seedlings, representing these lines, displayed up to ∼73- and ∼221-fold overexpression of the gene in hypocotyls and cotyledons, respectively. This overexpression resulted in statistically significant reversion to the non-mutant developmental phenotypes, including more than a full quantitative reversion. This reversion of phenotypes was generally accompanied by correlated responses in chlorophyll accumulation and altered expression of selected light signalling genes: PHYTOCHROME A, CRYPTOCHROME 1, ELONGATED HYPOCOTYL 5, and the gene encoding CHLOROPHYLL A/B-BINDING PROTEIN 4. Cumulatively, these results provide the missing link between DDB1 and its effects on tomato plant development

    The Growth of Cool Cores and Evolution of Cooling Properties in a Sample of 83 Galaxy Clusters at 0.3 < z < 1.2 Selected from the SPT-SZ Survey

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    We present first results on the cooling properties derived from Chandra X-ray observations of 83 high-redshift (0.3 < z < 1.2) massive galaxy clusters selected by their Sunyaev-Zel'dovich signature in the South Pole Telescope data. We measure each cluster's central cooling time, central entropy, and mass deposition rate, and compare to local cluster samples. We find no significant evolution from z~0 to z~1 in the distribution of these properties, suggesting that cooling in cluster cores is stable over long periods of time. We also find that the average cool core entropy profile in the inner ~100 kpc has not changed dramatically since z ~ 1, implying that feedback must be providing nearly constant energy injection to maintain the observed "entropy floor" at ~10 keV cm^2. While the cooling properties appear roughly constant over long periods of time, we observe strong evolution in the gas density profile, with the normalized central density (rho_0/rho_crit) increasing by an order of magnitude from z ~ 1 to z ~ 0. When using metrics defined by the inner surface brightness profile of clusters, we find an apparent lack of classical, cuspy, cool-core clusters at z > 0.75, consistent with earlier reports for clusters at z > 0.5 using similar definitions. Our measurements indicate that cool cores have been steadily growing over the 8 Gyr spanned by our sample, consistent with a constant, ~150 Msun/yr cooling flow that is unable to cool below entropies of 10 keV cm^2 and, instead, accumulates in the cluster center. We estimate that cool cores began to assemble in these massive systems at z ~ 1, which represents the first constraints on the onset of cooling in galaxy cluster cores. We investigate several potential biases which could conspire to mimic this cool core evolution and are unable to find a bias that has a similar redshift dependence and a substantial amplitude.Comment: 17 pages with 15 figures, plus appendix. Published in Ap
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