Past electron-positron g-2 experiments yielded sharpest bound on CPT violation for point particles

In our past experiments on a single electron and positron we measured the cyclotron and spin-cyclotron difference frequencies omega_c and omega_a and the ratios a = omega_a/ omega_c at omega_c = 141 Ghz for e^- and e^+ and later, only for e^-, also at 164 Ghz. Here, we do extract from these data, as had not done before, a new and very different figure of merit for violation of CPT symmetry, one similar to the widely recognized impressive limit |m_Kaon - m_Antikaon|/m_Kaon < 10^-18 for the K-mesons composed of two quarks. That expression may be seen as comparing experimental relativistic masses of particle states before and after the C, P, T operations had transformed particle into antiparticle. Such a similar figure of merit for a non-composite and quite different lepton, found by us from our Delta a = a^- - a^+ data, was even smaller, h_bar |omega_a^- - omega_a^+|/2m_0 c^2 = |Delta a| h_bar omega_c/2m_0 c^2) < 3(12) 10^-22.Comment: Improved content, Editorially approved for publication in PRL, LATEX file, 5 pages, no figures, 16

Self-Excitation and Feedback Cooling of an Isolated Proton

The first one-proton self-excited oscillator (SEO) and one-proton feedback cooling are demonstrated. In a Penning trap with a large magnetic gradient, the SEO frequency is resolved to the high precision needed to detect a one-proton spin flip. This is after undamped magnetron motion is sideband-cooled to a 14 mK theoretical limit, and despite random frequency shifts (larger than those from a spin flip) that take place every time sideband cooling is applied in the gradient. The observations open a possible path towards a million-fold improved comparison of the antiproton and proton magnetic moments

Theoretical energies of low-lying states of light helium-like ions

Rigorous quantum electrodynamical calculation is presented for energy levels of the 1^1S, 2^1S, 2^3S, 2^1P_1, and 2^3P_{0,1,2} states of helium-like ions with the nuclear charge Z=3...12. The calculational approach accounts for all relativistic, quantum electrodynamical, and recoil effects up to orders m\alpha^6 and m^2/M\alpha^5, thus advancing the previously reported theory of light helium-like ions by one order in \alpha.Comment: 18 pages, 9 tables, 1 figure, with several misprints correcte

Lecanemab in early Alzheimer\u27s disease

BACKGROUND: The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer\u27s disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with early Alzheimer\u27s disease. METHODS: We conducted an 18-month, multicenter, double-blind, phase 3 trial involving persons 50 to 90 years of age with early Alzheimer\u27s disease (mild cognitive impairment or mild dementia due to Alzheimer\u27s disease) with evidence of amyloid on positron-emission tomography (PET) or by cerebrospinal fluid testing. Participants were randomly assigned in a 1:1 ratio to receive intravenous lecanemab (10 mg per kilogram of body weight every 2 weeks) or placebo. The primary end point was the change from baseline at 18 months in the score on the Clinical Dementia Rating-Sum of Boxes (CDR-SB; range, 0 to 18, with higher scores indicating greater impairment). Key secondary end points were the change in amyloid burden on PET, the score on the 14-item cognitive subscale of the Alzheimer\u27s Disease Assessment Scale (ADAS-cog14; range, 0 to 90; higher scores indicate greater impairment), the Alzheimer\u27s Disease Composite Score (ADCOMS; range, 0 to 1.97; higher scores indicate greater impairment), and the score on the Alzheimer\u27s Disease Cooperative Study-Activities of Daily Living Scale for Mild Cognitive Impairment (ADCS-MCI-ADL; range, 0 to 53; lower scores indicate greater impairment). RESULTS: A total of 1795 participants were enrolled, with 898 assigned to receive lecanemab and 897 to receive placebo. The mean CDR-SB score at baseline was approximately 3.2 in both groups. The adjusted least-squares mean change from baseline at 18 months was 1.21 with lecanemab and 1.66 with placebo (difference, -0.45; 95% confidence interval [CI], -0.67 to -0.23; P\u3c0.001). In a substudy involving 698 participants, there were greater reductions in brain amyloid burden with lecanemab than with placebo (difference, -59.1 centiloids; 95% CI, -62.6 to -55.6). Other mean differences between the two groups in the change from baseline favoring lecanemab were as follows: for the ADAS-cog14 score, -1.44 (95% CI, -2.27 to -0.61; P\u3c0.001); for the ADCOMS, -0.050 (95% CI, -0.074 to -0.027; P\u3c0.001); and for the ADCS-MCI-ADL score, 2.0 (95% CI, 1.2 to 2.8; P\u3c0.001). Lecanemab resulted in infusion-related reactions in 26.4% of the participants and amyloid-related imaging abnormalities with edema or effusions in 12.6%. CONCLUSIONS: Lecanemab reduced markers of amyloid in early Alzheimer\u27s disease and resulted in moderately less decline on measures of cognition and function than placebo at 18 months but was associated with adverse events. Longer trials are warranted to determine the efficacy and safety of lecanemab in early Alzheimer\u27s disease. (Funded by Eisai and Biogen; Clarity AD ClinicalTrials.gov number, NCT03887455.)

Dissociative experiences in the general population in the Netherlands and Belgium: a study with the Dissociative Questionaire (DIS-Q)

p. 180-184This article describes the results of the first European study on the prevalence of dissociative experiences in the general population of Belgium (Flanders) and the Netherlands. Dissociative experiences were assessed with a new self-reporting dissociation questionnaire (DIS-Q). The DIS-Q has been administered to a representative sample of the Dutch and Flemish population (N=374). The results show that dissociative experiences are quite common in the general population, and that their frequency is declining with age. About 3 percent of the population (the majority men) reports serious dissociative phenomena, and 1 percent shows scores as high as patients with multiple personality disorder. These findings suggest that dissociative disorders are seriously under-diagnosed by mental health professionals

Breaking CPT by mixed non-commutativity

The mixed component of the non-commutative parameter \theta_{\mu M}, where \mu = 0,1,2,3 and M is an extra dimensional index may violate four-dimensional CPT invariance. We calculate one and two-loop induced couplings of \theta_{\mu 5} with the four-dimensional axial vector current and with the CPT odd dim=6 operators starting from five-dimensional Yukawa and U(1) theories. The resulting bounds from clock comparison experiments place a stringent constraint on \theta_{\mu 5}, |\theta_{\mu 5}|^{-1/2} > 5\times 10^{11} GeV. The orbifold projection and/or localization of fermions on a 3-brane lead to CPT-conserving physics, in which case the constraints on \theta{\mu 5} are softened.Comment: 4 pages, latex, 1 figur