Comparison of Visual Analog Pain Score Reported to Physician vs Nurse in Nonoperatively Treated Foot and Ankle Patients

Background: Patient reported outcome measures (PROMs) are taking a more prominent role in Orthopedics as health care seeks to define treatment outcomes. The Visual Analogue Scale (VAS) is considered a reliable measure of acute pain. A previous study found that operative candidates’ VAS pain score was significantly higher when reported to the surgeon compared to the nurse. This study’s aim is to examine whether this phenomenon occurs in nonoperative patients. We hypothesize that patients’ VAS scores reported to the surgeon and a nurse will be the same Methods: This study is a retrospective cohort of 201 consecutive nonoperative patients treated by a single surgeon. Patients were asked to rate pain intensity by a nurse followed by the surgeon using a horizontal VAS, 0 “no pain” to 10 worst pain”. Differences in reported pain levels were compared with data from the previous cohort of 201 consecutive operative patients. Results: The mean VAS score reported to the nurse was 3.2 whereas the mean VAS score reported to the surgeon was 4.2 (p\u3c.001). The mean difference in VAS scores reported for operative patients was 2.9, whereas the mean difference for nonoperative patients was 1.0 (p \u3c .001). Conclusion: This study found statistically significant differences between VAS scores reported to the surgeon versus the nurse in nonoperative patients which support the trend found in our previous study, where operative patients reported significantly higher scores to the surgeon. The mean difference between reported pain scores is significantly higher for operative patients compared to nonoperative patients

The HERMES Solar Atlas and the spectroscopic analysis of the seismic solar analogue KIC3241581

Solar-analog stars provide an excellent opportunity to study the Sun's evolution, i.e. the changes with time in stellar structure, activity, or rotation for solar-like stars. The unparalleled photometric data from the NASA space telescope Kepler allows us to study and characterise solar-like stars through asteroseismology. We aim to spectroscopically investigate the fundamental parameter and chromospheric activity of solar analogues and twins, based on observations obtained with the HERMES spectrograph and combine them with asteroseismology. Therefore, we need to build a solar atlas for the spectrograph, to provide accurate calibrations of the spectroscopically determined abundances of solar and late type stars observed with this instrument and thus perform differential spectral comparisons. We acquire high-resolution and high signal-to-noise spectroscopy to construct three solar reference spectra by observing the reflected light of Vesta and Victoria asteroids and Europa (100<S/N<450) with the \Hermes spectrograph. We then observe the Kepler solar analog KIC3241581 (S/N~170). We constructed three solar spectrum atlases from 385 to 900 nm obtained with the Hermes spectrograph from observations of two bright asteroids and Europa. A comparison between our solar spectra atlas to the Kurucz and HARPS solar spectrum shows an excellent agreement. KIC3241581 was found to be a long-periodic binary system. The fundamental parameter for the stellar primary component are Teff=5689+/-11K, logg=4.385+/-0.005, [Fe/H]=+0.22+/-0.01, being in agreement with the published global seismic values confirming its status of solar analogue. KIC 3241581 is a metal rich solar analogue with a solar-like activity level in a binary system of unknown period. The chromospheric activity level is compatible to the solar magnetic activity.Comment: 12 pages, 8 figures, accepted for publication in A&

Effect of temperature on the morphometrical and physical parameters of erythrocytes and polymorphonuclear leucocytes in Carassius gibelio (Bloch)

Dynamics of the morphometric and physical properties of hemocytes of the Prussian carp Carassius gibelio (Bloch) under the influence of a temperature factor has been studied with atomic force microscopy in experiments in vitr

Study of the Correlation Between Bronchial Hyperresponsiveness and Exhaled Nitric Oxide in Subjects with Suspected Symptoms of Asthma

Background: Bronchial hyperresponsiveness (BHR) is one of main features of asthma within chronic inflammation and reversible bronchoconstriction. Actually, methacholine challenge is useful method to detect BHR in subjects with suspected asthma symptoms. However, this method has some limitations due to its safety and side effects. The measure of exhaled nitric oxide (NO) demonstrates currently as the alternative method for methacholine challenge. Methods: Ninety-five subjects had at least one of the following symptoms were included in this study: wheezing or chest tightness during exercise, chronic cough, or nocturnal coughing. They were divided into two groups depending on the positivity or negativity of BHR. Lung function test, exhaled NO measurement, and methacholine challenge were done for each study subject. Results: There were no significant differences between two groups for age and male/female ratio (41 ± 22 vs 38 ± 23 years old and 0.9 vs 1.1; P > 0.05 and P > 0.05; respectively). The percentage of wheezing and nocturnal coughing in subjects with positive BHR (BHR+) was significantly higher than that in subjects with negative BHR (BHR-: 70.9% and 64.5% vs 31.2% and 45.1%; P<0.001 and P<0.01; respectively). FENO measured at 50 mL/s in subjects with BHR+ was significantly higher subjects with BHR- (36 ± 10 ppb vs 11 ± 9 ppb; P<0.001). There was a significant correlation between FENO-50 mL/s and methacholine dose in subjects with BHR+ (R= -0.695; P<0.001). FENO-50 mL/s at 35 ppb had 86.7% of sensibility and 82.9% of specificity for diagnosis of BHR. Conclusion: FENO is a useful biomarker for diagnosis of asthma in subjects with suspected symptoms of asthma. FENO level has a high sensitivity and specificity for screening out subjects with BHR. The measurement of exhaled NO may be an alternative method for detecting BHR in diagnosis of asthma in clinical practice

Modelagem de crescimento e produção usando o modelo Simflora.

Importância da modelagem de dinâmica florestal na Amazônia Brasileira; Modelagem de crescimento e produção usando o Simflora; Outros documentos disponíveis; Instalação; Simulações únicas; Dados; Começando; Janelas de exibição; Rodando o modelo; Resultados; Simulando silvicultura; A escolha de módulos e valores dos parâmetros; Exemplo; Simulações múltiplas; Começando uma simulação múltipla; Criando um arquivo de dados de saída; Rodando simulações múltiplas; Examinando e analisando os resultados; Experiências de uso do Simflora e suas implicações para políticas públicas; Indonésia; Guiana Inglesa; Brasil; Padrões observados em relação à exploração madeireira e às lacunas de conhecimento de dinâmica florestal de diferentes países tropicais

The seasonality expressed in motility of frog Rana Ridibunda Pall 1771 erythrocytes and leukocytes in agarose gel under the influence of the temperature

The agarose migration test rexealed the influence of temperature on seasonal fluctuation of locomotional activity of nuclear hemocytes of frogs of the genus Rana Ridibunda Pall. It’s been shown that at different incubation temperatures, the spontaneous migration area of blood cells changed in spring and summer, and did not change during autumn and winte

Seasonal fluctuations of migratory activity of ertebrate nuclear hemocytes at different incubation temperatures

Agarose migration test has shown that nuclear erythrocytes of Cyprinus carpio, Rana ridibunda, and Gallus domesticus are capable for spontaneous locomotions. The migration of red blood cells from frogs is associated with formations of long pseudopodia, whereas that from carps and hens - with short protrusion

A Schr\"odinger Equation for Evolutionary Dynamics

We establish an analogy between the Fokker-Planck equation describing evolutionary landscape dynamics and the Schr\"{o}dinger equation which characterizes quantum mechanical particles, showing how a population with multiple genetic traits evolves analogously to a wavefunction under a multi-dimensional energy potential in imaginary time. Furthermore, we discover within this analogy that the stationary population distribution on the landscape corresponds exactly to the ground-state wavefunction. This mathematical equivalence grants entry to a wide range of analytical tools developed by the quantum mechanics community, such as the Rayleigh-Ritz variational method and the Rayleigh-Schr\"{o}dinger perturbation theory, allowing us to not only make reasonable quantitative assessments but also explore fundamental biological inquiries. We demonstrate the effectiveness of these tools by estimating the population success on landscapes where precise answers are elusive, and unveiling the ecological consequences of stress-induced mutagenesis -- a prevalent evolutionary mechanism in pathogenic and neoplastic systems. We show that, even in a unchanging environment, a sharp mutational burst resulting from stress can always be advantageous, while a gradual increase only enhances population size when the number of relevant evolving traits is limited. Our interdisciplinary approach offers novel insights, opening up new avenues for deeper understanding and predictive capability regarding the complex dynamics of evolving populations

A Schrödinger Equation for Evolutionary Dynamics

We establish an analogy between the Fokker–Planck equation describing evolutionary landscape dynamics and the Schrödinger equation which characterizes quantum mechanical particles, showing that a population with multiple genetic traits evolves analogously to a wavefunction under a multi-dimensional energy potential in imaginary time. Furthermore, we discover within this analogy that the stationary population distribution on the landscape corresponds exactly to the ground-state wavefunction. This mathematical equivalence grants entry to a wide range of analytical tools developed by the quantum mechanics community, such as the Rayleigh–Ritz variational method and the Rayleigh–Schrödinger perturbation theory, allowing us not only the conduct of reasonable quantitative assessments but also exploration of fundamental biological inquiries. We demonstrate the effectiveness of these tools by estimating the population success on landscapes where precise answers are elusive, and unveiling the ecological consequences of stress-induced mutagenesis—a prevalent evolutionary mechanism in pathogenic and neoplastic systems. We show that, even in an unchanging environment, a sharp mutational burst resulting from stress can always be advantageous, while a gradual increase only enhances population size when the number of relevant evolving traits is limited. Our interdisciplinary approach offers novel insights, opening up new avenues for deeper understanding and predictive capability regarding the complex dynamics of evolving populations