Improved depth sensitivity by separation of excitation and detection coils

A laparoscopic probe for magnetic sentinel node biopsy has been developed. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as a tracer. They are selectively detected by Differential Magnetometry (DiffMag). Excitation and detection coils are separated. To make this possible, we developed active compensation, which removes influence of the excitation field. Separation of coils leads to improved depth sensitivity, from 20 mm with our handheld probe to 80 mm with our novel laparoscopic probe. As stated by Biot-Savart law, we win a factor distance to the third power by separating the excitation and detection part of the system

Characterization of superparamagnetic iron oxide nanoparticles in biological environments

Characterization of superparamagnetic iron oxide nanoparticles on biological environment

Separation of excitation and detection coils to locate superparamagnetic iron oxide nanoparticles in vivo

The aim of this study is to develop a novel laparoscopic probe for sentinel node biopsy. The latter is a procedure to analyze the lymph node status of cancer patients [1], enabling personalized patient care