Cross inhibition models for the transmission of hormonal signals

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Long-term evolution of the mineral metabolism after renal transplantation : a prospective, single-center cohort study

Background. Abnormalities in bone and mineral metabolism are common after renal transplantation (RT) but information on their long-term time course is scarce. Objectives. (1) Evaluate the time course of biochemical parameters of bone and mineral metabolism over 60 months after RT; (2) identify predictors for persistent hyperparathyroidism (HPT). Design. Prospective, longitudinal, single-center cohort study. Methods. We determined serum levels (mean values +/- standard deviations) of intact parathyroid hormone (iPTH), calcium (Ca), phosphorus (P), magnesium (Mg), alkaline phosphatase (APh), calcitriol, and creatinine (Cr) preoperatively as well as 6, 12, 24, 36, 48, and 60 months after cadaveric RT in 49 patients. We in addition recorded demographic, clinical, and therapeutic data. Results. Pretransplantation iPTH stabilized from 194.2 +/- 273.5 to 71.5 +/- 50.7 ng/L at 6 months. Serum Ca (9.5 +/- 1.1 mg/dL) and APh (81.9 +/- 42.1 U/L) did not change. Baseline serum P (5.7 +/- 1.8 mg/dL) and serum Mg (2.4 +/- 0.4 mg/dL) decreased to normal ranges from month 6 onward. Low baseline calcitriol (22.4 +/- 21.8 pmol/L) normalized slowly by 12 months (95.4 +/- 46.7 pmol/L). Stable graft function (53.2 +/- 15.8 mL/min) was achieved from 6 months onward. By 60 months, 26.5% of patients had a serum Ca above 9.8 mg/dL and serum P below 2.7 mg/dL; 22.4%, an Mg below 1.7 mg/dL and 8.2%, a serum iPTH more than 2.5-fold the upper limit of normal. Upon multiple regression analyses the iPTH at 60 months was influenced by a dialysis duration >= 2 years (beta = 0.259, P = .003), body mass index > 25 kg/m(2) (beta = 0.257, P = .006), baseline iPTH (beta = 0.182, P = .036), serum Cr (beta = 0.268, P = .002) and Mg (beta = -0.242, P = .006). Conclusions. Hypercalcemia, hypophosphatemia, hypomagnesemia, and elevated iPTH persist in a subset of post-RT patients. Pretransplantation iPTH and obesity, dialysis duration, and posttransplant serum creatininemia and hypomagnesemia independently contribute to persistent HPT

CONCENTRATIONS BASALES ET DEBITS INTEGRES POST-PRANDIAUX DE GASTRIENE CHEZ DES MALADES ATTEINTS DE GASTRITE ATROPHIQUE OU D'ULCERE DUODENAL. LIMITES A L'UTILITE DIAGNOSTIQUE

Maximal acid outputs were determined during intravenous pentagastrin tests (6 μg/kg/h) in 119 male subjects: 17 controls, 74 patients with duodenal ulcer and 28 with atrophic gastritis. Basal and postprandial serum gastrin levels were also determined in order to estimate the integrated gastrin response to the meal. In patients with atrophic gastritis the maximal acid output was decreased (p < 0.01) and the integrated gastric response was increased (p < 0.01) but the basal gastrin levels in these patients did not differ from that of controls. An integrated gastrin response greater than 2.5 ng/ml/100 min was observed in 89% of patients with atrophic gastritis. An integrated gastrin response smaller than 2.5 ng/ml/100 min was observed in 76% of controls. The maximal acid output was smaller than 20 mmol/l in all patients with atrophic gastritis but was greater than this value in all controls. In duodenal ulcer patients, the measured parameters were not significantly different from control values. The measure of the integrated gastrin response which reflects the presence of antral endocrine hyperactivity may be useful to detect patients with atrophic gastritis, but this test is less sensitive and less specific than the determination of the maximal acid output.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Intracellular mediators in the mechanism of action of hormones or neurotransmitters: Reciprocal controls

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Protein kinase and cyclic 3',5' AMP: significance of binding and activation constants

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Implications of cross inhibitory interactions of potential mediators of hormone and neurotransmitter action

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Lymphangiectasies et entéropathie exsudative

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Lymphangiectasies et entéropathie exsudative

The authors report the case of a 56 yr old man suffering from oedema of the inferior limbs. This oedema was secondary to a protein-loosing enteropathy of lymphatic origin. Histological examination revealed intestinal lymphangiectasia. After reviewing all the cases of secondary intestinal lymphangiectasia, the diagnosis of primary lymphangiectasia was proposed. Middle chain triglycerides administration induced clinical and biological improvement.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Theoretical Simulation of the cAMP System

info:eu-repo/semantics/publishe