1,562 research outputs found
Nederlandse kansspelregulering aan de Europese maat. De zaken Ladbrokes en Sporting Exchange (Betfair) over internetaanbod en kansspelmonopolies in perspectief: les jeux sont faits?
The progression of EU law: Accommodating change and upholding value
Cyclosporine A reduces microvascular obstruction and preserves left ventricular function deterioration following myocardial ischemia and reperfusion
Postconditioning and cyclosporine A prevent
mitochondrial permeability transition pore opening providing
cardioprotection during ischemia/reperfusion.
Whether microvascular obstruction is affected by these
interventions is largely unknown. Pigs subjected to coronary
occlusion for 1 h followed by 3 h of reperfusion were
assigned to control (n = 8), postconditioning (n = 9) or
cyclosporine A intravenous infusion 10-15 min before the
end of ischemia (n = 8). Postconditioning was induced by
8 cycles of repeated 30-s balloon inflation and deflation.
After 3 h of reperfusion magnetic resonance imaging,
triphenyltetrazolium chloride/Evans blue staining and histopathology
were performed. Microvascular obstruction
(MVO, percentage of gadolinium-hyperenhanced area) was
measured early (3 min) and late (12 min) after contrast
injection. Infarct size with double staining was smaller in
cyclosporine (46.2 ± 3.1 %, P = 0.016) and postconditioning
pigs (47.6 ± 3.9 %, P = 0.008) versus controls
(53.8 ± 4.1 %). Late MVO was significantly reduced by
cyclosporine (13.9 ± 9.6 %, P = 0.047) but not postconditioning
(23.6 ± 11.7 %, P = 0.66) when compared with
controls (32.0 ± 16.9 %). Myocardial blood flow in the
late MVO was improved with cyclosporine versus controls
(0.30 ± 0.06 vs 0.21 ± 0.03 ml/g/min, P = 0.002) and
was inversely correlated with late-MVO extent ( = 0.93,
P\0.0001). Deterioration of left ventricular ejection
fraction (LVEF) between baseline and 3 h of reperfusion
was smaller with cyclosporine (-7.9 ± 2.4 %, P = 0.008)
but not postconditioning (-12.0 ± 5.5 %, P = 0.22) when
compared with controls (-16.4 ± 5.5 %). In the three
groups, infarct size (\beta = -0.69, P\0.001) and late MVO
(\beta = -0.33, P = 0.02) were independent predictors of
LVEF deterioration following ischemia/reperfusion
(R^{2} = 0.73, P\0.001). Despite both cyclosporine A and
postconditioning reduce infarct size, only cyclosporine A
infusion had a beneficial effect on microvascular damage
and was associated with better preserved LV function when
compared with controls
Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients
Summary To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofolsufentanil anaesthesia, were randomly assigned four groups: ideal body weight; ideal body weight + 20%; ideal body weight + 40%; and real body weight. Patients received sugammadex 2 mg.k
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