Workflow in Clinical Trial Sites & Its Association with Near Miss Events for Data Quality: Ethnographic, Workflow & Systems Simulation

10.1371/journal.pone.0039671PLoS ONE76

The phalangeal microgeodic syndrome in childhood: awareness leads to diagnosis

Phalangeal microgeodic syndrome is a rare but benign disorder that affects the fingers of children. This condition was originally described by Maroteaux in 1970. We present two patients who consulted a pediatrician with swelling of the digits of one or both hands. Both lacked additional clinical or biochemical signs. Radiological examination showed multiple small osteolytic areas with sclerotic lining and periostal reactions in the phalanges of the affected hands. These cases were treated with a conservative approach and spontaneous resolution occurred within weeks to months. As it is a rare disease, the clinical presentation can be misinterpreted as an infectious, inflammatory, or even malignant condition and prompts clinicians to expand the diagnostic process with radiological or nuclear imaging and even biopsy. In these patients, a timely clinical diagnosis by a physician who is aware of the disease prevented further investigations.status: publishe

Flood Modelling and Visualizations of Floods Through 3D Open Data

Part 3: Water and HydrosphereInternational audienceThis paper is devoted to 3D modelling at the city level from data sources considered as open. The open data presented in this paper enable free usage, modifications, and sharing by anyone for any purpose. The main motivation was to verify feasibility of a 3D visualization of floods purely based on open technologies and data. The presented state-of-the-art analysis comprises the evaluation of available 3D open data sources, including formats, Web-based technologies, and software used for visualizations of 3D models. A pilot Web application visualizing floods was developed to verify the applicability of discovered data sources. 3D visualizations of terrain models, 3D buildings, flood areas, flood walls and other related information are available in a pilot application for a selected part of the city of Prague. The management of different types of input data, the design of interactive functionality including navigation aids, and actual limitations and opportunities for future development are discussed in detail at the end