Clinical Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Response Evaluation after Primary Treatment of Advanced Epithelial Ovarian Cancer

Aims: To prospectively evaluate the use of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG-PET/CT) in the definition of the treatment response after primary treatment of advanced epithelial ovarian cancer (EOC). Materials and methods: Forty-nine patients with advanced EOC had an F-18-FDG PET/CT scan before and after primary treatment. The treatment response was defined with the currently used radiological and serological Response Criteria in Solid Tumors (RECIST1.1/GCIC) criteria and the modified PET Response Criteria in Solid Tumors (PERCIST). The concordance of the two methods was analysed. If the patient had a complete response to primary treatment by conventional criteria, the end of treatment F-18-FDG PET/CT scan (etPET/CT) was not opened until retrospectively at the time of disease progression. The ability of etPET/CT to predict the time to disease recurrence was analysed. The recurrence patterns were observed with an F-18-FDG PET/CT at the first relapse. Results: The agreement of the RECIST1.1/GCIC and modified PERCIST criteria in defining the primary treatment response in the whole patient cohort was good (weighted kappa coefficient = 0.78 ). Of the complete responders (n = 28), 34% had metabolically active lesions present in the etPET/CT, most typically in the lymph nodes. The same anatomical sites tended to activate at disease relapse, but were seldom the only site of relapse. In patients with widespread intra-abdominal carsinosis at diagnosis, the definition of metabolic response was challenging due to problems in distinguishing the physiological FDG accumulation in the bowel loops from the residual tumour in the same area. The presence of metabolically active lesions in the etPET/CT did not predict earlier disease relapse in the complete responders. Conclusions: In the present study, etPET/CT revealed metabolically active lesions in complete responders after EOC primary therapy, but they were insignificant for the patient's prognosis. The current study does not favour routine use of F-18-FDG PET/CT after EOC primary treatment for complete responders. (C) 2018 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.Peer reviewe

Virtual clinical trials identify effective combination therapies in ovarian cancer

A major issue in oncology is the high failure rate of translating preclinical results in successful clinical trials. Using a virtual clinical trial simulations approach, we present a mathematical framework to estimate the added value of combinatorial treatments in ovarian cancer. This approach was applied to identify effective targeted therapies that can be combined with the platinum-taxane regimen and overcome platinum resistance in high-grade serous ovarian cancer. We modeled and evaluated the effectiveness of three drugs that target the main platinum resistance mechanisms, which have shown promising efficacy in vitro, in vivo, and early clinical trials. Our results show that drugs resensitizing chemoresistant cells are superior to those aimed at triggering apoptosis or increasing the bioavailability of platinum. Our results further show that the benefit of using biomarker stratification in clinical trials is dependent on the efficacy of the drug and tumor composition. The mathematical framework presented herein is suitable for systematically testing various drug combinations and clinical trial designs in solid cancers

Discovering Europe's seabed geology: the EMODnet concept of uniform collection and harmonization of marine data

Maritime spatial planning, management of marine resources, environmental assessments and forecasting all require good seabed maps. Similarly there is a need to support the objectives to achieve Good Environmental Status in Europe's seas by 2020, set up by the European Commission's Marine Strategy Framework Directive. Hence the European Commission established the European Marine Observation and Data Network (EMODnet) programme in 2009, which is now in its fourth phase (2019–21). The programme is designed to assemble existing, but fragmented and partly inaccessible, marine data and to create contiguous and publicly available information layers which are interoperable and free of restrictions on use, and which encompass whole marine basins. The EMODnet Geology project is delivering integrated geological map products that include seabed substrates, sedimentation rates, seafloor geology, Quaternary geology, geomorphology, coastal behaviour, geological events such as submarine landslides and earthquakes, and marine mineral occurrences. Additionally, as a new product during the ongoing and preceding phase of the project, map products on submerged landscapes of the European continental shelf have been compiled at various time frames. All new map products have a resolution of 1:100 000, although finer resolution is presented where the underlying data permit. A multi-scale approach is adopted whenever possible. Numerous national seabed mapping programmes worldwide have demonstrated the necessity for proper knowledge of the seafloor. Acting on this, the European Commission established the European Marine Observation and Data Network (EMODnet) programme in 2009. The national geological survey organizations of Europe have a strong network of marine geological teams through the Marine Geology Expert Group of the association of European geological surveys (Eurogeosurveys). This network was the foundation of the EMODnet Geology consortium which today consists of the national geological surveys of Finland, the UK, Sweden, Norway, Denmark, Estonia, Latvia, Lithuania, Poland, The Netherlands, Belgium, France, Ireland, Spain, Italy, Slovenia, Croatia, Albania, Greece, Cyprus, Malta, Russia, Germany, Montenegro and Iceland, as well as marine teams of research organizations in Portugal (IPMA), Bulgaria (IO-BAS), Romania (GeoEcoMar), the UK (CEFAS), Greece (HCMR) and Ukraine (PSRGE, replaced in the fourth phase by Institute of Geological Sciences, NAS of Ukraine). The consortium is further strengthened with experts from six universities: Edge Hill University (UK), Sapienza University of Rome (Italy), University of Tartu (Estonia), University of Crete through FORTH-ICS, Institute of Marine Science and Technology of Dokuz Eylul University (Turkey), and EMCOL Research Centre of Istanbul Technical University – altogether, 30 partners and nine subcontractors. The EMODnet Geology programme is now in its fourth phase, which started in September 2019. In addition to geological information, the wider EMODnet programme aims to also bring together information from European seas on seabed habitats, physical properties, chemistry, biology, human activities and hydrography. This paper describes the EMODnet Geology project and the different end products which were delivered in the end of the third phase and will be further developed during the recent fourth phase of the project

The European Marine Observation and Data Network (EMODnet): Visions and roles of the gateway to marine data in Europe

Marine data are needed for many purposes: for acquiring a better scientific understanding of the marine environment, but also, increasingly, as marine knowledge for decision making as well as developing products and services supporting economic growth. Data must be of sufficient quality to meet the specific users' needs. It must also be accessible in a timely manner. And yet, despite being critical, this timely access to known-quality data proves challenging. Europe's marine data have traditionally been collected by a myriad of entities with the result that much of our data are scattered throughout unconnected databases and repositories. Even when data are available, they are often not compatible, making the sharing of the information and data aggregation particularly challenging. In this paper, we present how the European Marine Observation and Data network (EMODnet) has developed over the last decade to tackle these issues. Today, EMODnet is comprised of more than 150 organizations which gather marine data, metadata, and data products and make them more easily accessible for a wider range of users. EMODnet currently consists of seven sub-portals: bathymetry, geology, physics, chemistry, biology, seabed habitats, and human activities. In addition, Sea-basin Checkpoints have been established to assess the observation capacity in the North Sea, Mediterranean, Atlantic, Baltic, Artic, and Black Sea. The Checkpoints identify whether the observation infrastructure in Europe meets the needs of users by undertaking a number of challenges. To complement this, a Data Ingestion Service has been set up to tackle the problem of the wealth of marine data that remain unavailable, by reaching out to data holders, explaining the benefits of sharing their data and offering a support service to assist them in releasing their data and making them available through EMODnet. The EMODnet Central Portal (www.emodnet.eu) provides a single point of access to these services, which are free to access and use. The strategic vision of EMODnet in the next decade is also presented, together with key focal areas toward a more user-oriented service, including EMODnet for business, internationalization for global users, and stakeholder engagement to connect the diverse communities across the marine knowledge value chain