16 research outputs found

    Four years of Type Ia Supernovae Observed by TESS: Early Time Light Curve Shapes and Constraints on Companion Interaction Models

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    We present 307 Type Ia supernova (SN) light curves from the first four years of the TESS mission. We use this sample to characterize the shapes of the early time light curves, measure the rise times from first light to peak, and search for companion star interactions. Using simulations, we show that light curves must have noise <<10% of the peak to avoid biases in the early time light curve shape, restricting our quantitative analysis to 74 light curves. We find that the mean power law index tβ1t^{\beta_1} of the early time light curves is 1.83±\pm 0.57 and the mean rise time to peak is 15.7 ±\pm 3.5 days. We also estimate the underlying population distribution and find a Gaussian component with mean β1=2.29\beta_1 = 2.29, width 0.34, and a tail extending to values less than 1.0. We use model comparison techniques to test for the presence of companion interactions. In contrast to recent results in the literature, we find that the data can rarely distinguish between models with and without companion interactions, and caution is needed when claiming detections of early time flux excesses. Nevertheless, we find three high-quality SN light curves that tentatively prefer the addition of a companion interaction model, but the statistical evidence is not robust. We also find two SNe that disfavor the addition of a companion interaction model to a curved power law model. Taking the 74 SNe together, we calculate 3σ\sigma upper limits on the presence of companion signatures to control for orientation effects that can hide companions in individual light curves. Our results rule out common progenitor systems with companions having Roche lobe radii >> 31 R⊙_{\odot} (99.9% confidence level) and disfavor companions having Roche lobe radii >> 10 R⊙_{\odot} (95% confidence level). Lastly, we discuss the implications of our results for the intrinsic fraction of single degenerate progenitor systems.Comment: 40 pages, 23 figures, resubmitted to ApJ. Figure sets for all 307 objects in Figures 3, 13, 14, and 16, can be viewed at https://space.mit.edu/home/faus/snIa_fig_sets/ in advance of the online journal articl

    Evaluation of Allelic Expression of Imprinted Genes in Adult Human Blood

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    Imprinted genes are expressed from only one allele in a parent-of-origin dependent manner. Loss of imprinted (LOI) expression can result in a variety of human disorders and is frequently reported in cancer. Biallelic expression of imprinted genes in adult blood has been suggested as a useful biomarker and is currently being investigated in colorectal cancer. In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults

    Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes

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    The International Crocodilian Genomes Working Group (ICGWG) will sequence and assemble the American alligator (Alligator mississippiensis), saltwater crocodile (Crocodylus porosus) and Indian gharial (Gavialis gangeticus) genomes. The status of these projects and our planned analyses are described

    Integrating Pediatric Behavioral Health Into Rural Primary Care: Research Findings

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    A New Model for Behavioral Health Services in Primary Care

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    Influence of coagulation factor 13A (F13A)

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    Further refinement of the critical minimal genetic region for the imprinting disorder 6q24 transient neonatal diabetes

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    AIMS/HYPOTHESIS: Transient neonatal diabetes (TND) is associated with overexpression of genes within a critical region on 6q24. This study aims to refine the boundaries of this region to reduce the number of potential candidate genes for 6q24 TND.METHODS: Fifteen patients with transient neonatal diabetes and submicroscopic chromosome 6 duplications were investigated. The duplications were confirmed by microsatellite analysis and subsequently mapped using tiled chromosome 6 array Comparative Genomic Hybridisation (aCGH) and MLPA. Duplication boundaries were compared to identify the minimal shared region of duplication. These data were then used with available clinical data to identify associations between size of 6q24 duplication and severity of TND phenotype.RESULTS: Alignment of the minimal region of duplication to the human genome reduced the minimal TND critical region, formerly estimated at 440 kb, to 160-173 kb, revealing PLAGL1 (pleiomorphic adenoma gene-like 1) and HYMAI (imprinted in hydatidiform mole) to be the only genes wholly included therein. Additionally, the complete paternal duplication of a region containing the theoretical protein FAM164B was associated with the severe growth restriction observed in 6q24 duplication patients.CONCLUSIONS/INTERPRETATION: This study has significantly reduced the critical region associated with 6q24 TND. It has eliminated several previous TND candidate genes, leaving the overlapping imprinted genes PLAGL1 and HYMAI as the only remaining complete candidate genes for 6q24 TND. Moreover, these data provide the first evidence that an additional region, encompassing the theoretical protein FAM164B, may have a critical role in the growth restriction phenotype observed in many 6q24 TND patients
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