Computational modelling of the behaviour of biomarker particles of colorectal cancer in fecal matter

Colorectal adenocarcinoma is one of the carcinogenic diseases that is increasing the morbidity and mortality rates worldwide. The disease initially occurs through the segregation of biomarker substances in the human system without manifesting symptoms that affect the health of the carrier. Early detection would allow the application of more effective treatments, less invasive procedures and reduce the development of cancer. The purpose of this investigation was the elaboration of a mathematical model and the development of computational simulations to visualize the behavior of biomarker particles in transit through the colon. The flow conditions, properties of the viscous medium and biological regions of interest were established. Constitutive models, numerical conditions and solution strategies were determined. A numerical grid was used to represent the model of the colon and the human feces that carry the bioparticles (biomarkers). The results indicated the trajectories of the bioparticles in the fecal mass and the interactive movement with the natural contractions of the colon. The analysis of the movement of the biomarker particles can provide future less invasive alternatives for the detection in real time of the cancer by means of the implantation of biosensors in the walls of the colon

Prevalence of Emotions and Basic Feelings in Higher Education, Case: ESPOCH Marketing Career

This research aimed to determine the prevalence of basic emotions and feelings in higher education students, through a case study of students pursuing the marketing degree of the Polytechnic School of Chimborazo (ESPOCH). The research employed the MATEA model (fear, affection, sadness, anger and joy) and qualitative and quantitative approaches. The research design was descriptive, cross-sectional and non-experimental, and the methods used were inductive, deductive, analytical, synthetic and systemic. Data were collected through documentation and field review. The results indicated that there was a high level of fear, anger and joy in the students, a neutral level of sadness, and a positive feeling of affection. Given that anger and fear were identified at high levels in the students, we conclude that these feelings should be treated by ESPOCH’s Department of Well-being, Polytechnic and Psychology. Keywords: MATEA model, emotions, feelings, emotional codes. Resumen La investigación tiene como objetivo determinar la prevalencia de las emociones y sentimientos básicos en los estudiantes de educación superior, caso: Carrera de Mercadotecnia de la Escuela Superior Politécnica de Chimborazo (ESPOCH), se fundamenta en el modelo MATEA (miedo, afecto, tristeza, enojo y alegría) tiene un enfoque cualitativo y cuantitativo, de nivel descriptivo, de diseño transversal, no experimental, los métodos utilizados fueron inductivo, deductivo, analítico, sintético y sistémico en el proceso de revisión documental y de campo desarrollados en la presentación de resultados, discusión y conclusiones. Los resultados determinaron el sentimiento miedo su nivel es alto; el sentimiento afecto es positivo, el sentimiento tristeza se encuentra en nivel neutro, el sentimiento enojo su nivel es alto, el sentimiento alegría fue alto. Se concluye que los sentimientos enojo y miedo fueron identificados altos en los estudiantes, se recomienda que estos sentimientos deben ser tratados por los departamentos Bienestar Estudiantil Politécnico y Psicología de la ESPOCH. Palabras clave: modelo MATEA, emociones, sentimientos, códigos emocionales

Primary care supply and quality of care in England

We investigated the relationship between primary care supply and quality of care in England. We analysed 35 process measures of quality of care covering 13 medical conditions using English Longitudinal Study of Aging data linked to area of residence indicators. Greater GP density had a statistically significant and positive association with quality of care, and distance to GP practice had a statistically significant and negative association. The effects were concentrated in indicators of care related to cardiovascular diseases and arthritis, and on specific indicators for diabetes, incontinence and hearing problems. The results suggest that better primary care supply can improve quality of care

The Liquefaction of Sand Lenses Due to Cyclic Loading

Many studies have been conducted on the effects of cyclic loading on homogeneous saturated deposits of sand, and to a lesser extent on silt and clay. In contrast, very little research has been performed on the effects of cyclic loading on saturated sand lenses located within clay masses. Sand lenses and thin discontinuous layers of loose sand are frequently encountered in saturated clay or silt deposits located in areas of the United States prone to earthquakes. Sand lenses are also frequently associated with hydraulic fill structures, which are known to perform poorly during earthquake loading. The liquefaction and failure of sand lenses has been identified as a major factor in the Turnagain Heights Landslide during the 1964 Alaska Earthquake and lateral spreading landslides in the 1906 San Francisco Earthquake, among others. A major obstacle to laboratory testing of sand lenses is the modeling of a sand lens or lenses within a clay deposit or block, and finding equipment that can subject the sample to cyclic loading. Until now, only theoretical analyses of sand lens failure have been performed, with the most promising method utilizing the principles of Linear Elastic Fracture Mechanics (LEFM) theory. This study developed a method of constructing one or more sand lenses within a block of clay and then applying a uniform cyclic loading with a shaking table. For clay blocks with a single sand lens and with two sand lenses, behavior was closely monitored during the cyclic loading to the point of failure. The results of the testing verified that the principles of the LEFM theory can be used to determine the mode of failure of a sand lens or lenses due to cyclic loading

Analysis of Collective Behavior and the Psychology of the Masses. Case: October–2019, Ecuador

In this research, an analysis was performed of collective behavior and its relationship with the psychology of the masses. The objective was to explain the collective behavior of the masses following the events of October 2, 2019 in Ecuador. A quantitative approach was used. Data were collected through observation and using a registration form for the follow-up of written media. The results of the investigation identified causes of the collective protests to decree 883 pronounced by the Ecuadorian government, whose effect was a series of collective behaviors, according to the psychology of the masses; these were: imitation, acting as followers, looking for affection or acceptance, frustration, repressed and controlled emotions, emotional contagion, feeling protected, defending their rights and being heard. In addition, the indigenous behavior identified included leadership, perseverance, solidarity, union, the formation of a new generation of leaders, the use of digital media, and the Andean worldview on the participation of the family clan and death. Keywords: collective behavior, mass psychology, individual behavior. Resumen La presente investigación realiza un análisis del comportamiento colectivo y la relación con la psicología de las masas El objetivo de la investigación es explicar el comportamiento colectivo de las masas que conllevaron a los sucesos del 2 de octubre de 2019 en Ecuador. El desarrollo de la investigación se sustenta en el enfoque cuantitativo, en el nivel explicativo, en los tipos observacional, documental, retrospectivo y transversal. El método fue inductivo, al observar a los sujetos el de la investigación y los hechos sucedidos para ser analizados, la técnica fue la observación a través de una ficha de registro para seguimiento de los medios de comunicación escritos. Los resultados de la investigación identifican la causa de las protestas colectivas al decreto 883 pronunciado por el gobierno ecuatoriano, cuyo efecto fue una serie de comportamientos colectivos, que según la psicología de las masas buscan: la imitación, son seguidores, buscan afecto, aceptación, existe frustración, emociones reprimidas y controladas, contagio emocional, sentirse protegidos, defender sus derechos y ser escuchados. Se identificó: el comportamiento indígena su liderazgo, la constancia, la solidaridad, la unión y la formación de la nueva generación de líderes, el uso de los medios de comunicación digital y la cosmovisión andina sobre la participación del clan familiar y la muerte. Palabras clave: comportamiento colectivo, psicología de las masas, comportamiento individual

Prospective and Mental Change in Decision-Making in Critical Scenarios of Organizations (Review Article)

We understand from the study of neuroscience that our mind has the power to change according to the social and cultural context in which we operate. The purpose of this research was to present epistemological theory, its importance in influencing decision-making, and strategic approaches from the perspective of complexity and neuroscience. For this, an in-depth bibliographic review was carried out based on the epistemological point of view and critical reading of published articles. The results demonstrated considerations about the presence of multiple philosophical traditions in the scientific process; the role of leadership and neuroscience as the axis of knowledge and their value for decision-making; and how, based on the paradigmatic dialectic, a new mental model and innovative foresight are useful for understanding the structures that require new models of planning for the future where possible and desirable. Thus, we conclude that a change of mentality to a new philosophy of interpretation of reality is important for the complexity of the construction of the future. Keywords: neurosciences, quality, managerial skills, neuroliderazgo. Resumen Desde la neurociencia nuestra mente tiene el poder de cambiar de acuerdo al contexto social y cultural en la que nos desenvolvemos, para ello hay que darle al cerebro la importancia de algo nuevo. El artículo tiene como propósito presentar la teoría epistemológica, y su importancia para formar mentes y pensamientos positivos para la toma de decisiones, y mejorar los enfoques estratégicos desde la perspectiva de la complejidad y la neurociencia; para ello se realizó una revisión bibliográfica a profundidad basados en dos enfoques desde lo epistemológico y la lectura crítica de artículos publicados. Frente a tal escenario, se pretende exponer consideraciones acerca de la presencia de estas tres tradiciones filosóficas en la manera científica argumentado liderazgo y neurociencia como eje del conocimiento y sobre su valor para la toma de decisiones fundamentados en la dialéctica paradigmática hacia un nuevo modelo mental e innovador, la prospectiva es útil para comprender las estructuras que requieren nuevos modelos de planificación del futuro en lo posible y lo deseable. En el nivel académico esta la respuesta a la complejidad para la construcción del futuro, es importante un cambio de mentalidad que este sujeto a una nueva filosofía de interpretación de la realidad. Palabras claves: neurociencias, calidad, habilidades directivas, neuroliderazgo

Effects of Alzheimer’s Disease on Visual Target Detection: A “Peripheral Bias”

Visual exploration is an omnipresent activity in everyday life, and might represent an important determinant of visual attention deficits in patients with Alzheimer’s Disease (AD). The present study aimed at investigating visual search performance in AD patients, in particular target detection in the far periphery, in daily living scenes. Eighteen AD patients and 20 healthy controls participated in the study. They were asked to freely explore a hemispherical screen, covering ±90°, and to respond to targets presented at 10°, 30°, and 50° eccentricity, while their eye movements were recorded. Compared to healthy controls, AD patients recognized less targets appearing in the center. No difference was found in target detection in the periphery. This pattern was confirmed by the fixation distribution analysis. These results show a neglect for the central part of the visual field for AD patients and provide new insights by mean of a search task involving a larger field of view