Isquemia aguda de miembros inferiores secundaria a ergortismo

Paciente de género femenino, de 21 años de edad, quien ingresó por dolor progresivo e intenso en miembros inferiores, y refirió antecedente reciente de ingestión de derivados del ergot. Al examen físico se observó ausencia de pulsos en ambos miembros inferiores. Por angiotomografia se documentó disminución severa, generalizada y bilateral, del calibre de los vasos arteriales de miembros inferiores. Se diagnosticó isquemia arterial aguda secundaria a ergotismo y se inició tratamiento con vasodilatadores y calcio-antagonistas, que resolvió los síntomas en su totalidad.21 years old female patient admitted for progressive and intense pain in lower limbs, that narrated a recent history of ergot ingestion. On physical examination there was absence of pulses in both lower limbs. Severe, generalized and bilateral decrease of caliber of arterial vessels of the lower limbs was documented by angiotomography. Acute arterial ischemia of lower limbs secondary to ergotism was diagnosed and treatment with vasodilators and calcium antagonists was initiated, resolving entirely the symptoms

Herdbook analyses of the Asturiana beef cattle breeds

International audienc

The District Energy-Efficient Retrofitting of Torrelago (Laguna de Duero – Spain)

The urban growth is estimated to reach up the 66 % by 2050 and consequently the need of resources within the cities will increase significantly. This, combined with the 40 % of energy consumption and 36 % of CO2 emissions of the building sector, makes necessary to accelerate the transition towards more sustainable cities. The CITyFiED project contributes to this transition, aiming to develop an innovative and holistic methodological approach for energy-efficient district renovation and deliver three large scale demonstration cases in the cities of Lund (Sweden), Laguna de Duero (Spain) and Soma (Turkey). CITyFiED methodology consists of several phases that ease the decision-making tasks towards the district renovation, considering the energy efficiency as the main pillar and local authorities as clients. For the case of Torrelago district (Spain) the intervention consists of a set of energy conservative measures including the facąde retrofitting of 143.025 m2 of living space in 31 twelve-storey buildings; the renovation of the district heating network with a new biomass thermal plant; the integration of renewable energy sources, including a micro-cogeneration system, and the installation of individual smart meters. After the renovation action, one-year monitoring campaign is ongoing. The CITyFiED monitoring platform will collect information from the energy systems and deliver environmental, technical, economic and social key performance indicators by March 2019. At the end of the project the achievement of the predefined goals will be verified: Up to 36 % of energy saving and 3,429 tons-CO2/yr emissions saving covering the 59,4 % of the energy consumption with renewable sources.The research and results presented in this paper evolve from activities related to the CITyFiED project, which has received funding from the European Commission under the Grant Agreement no. 609129. This article is the result of cooperative research work of many experts from various countries and we would like to gratefully acknowledge the rest of the CITyFiED partners

Obstructive Sleep Apnoea Syndrome, Endothelial Function and Markers of Endothelialization. Changes after CPAP

STUDY OBJECTIVES: This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. DESIGN: Observational study, before and after CPAP therapy. SETTING AND PATIENTS: We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. FMD was assessed non-invasively in vivo using the Laser-Doppler flowmetry. Circulating cell-free DNA (cf-DNA) and microparticles (MPs) were measured as markers of endothelial damage and the vascular endothelial growth factor (VEGF) was determined as a marker of endothelial restoration process. MEASUREMENTS AND RESULTS: After three month with CPAP, FMD significantly increased (1072.26 ± 483.21 vs. 1604.38 ± 915.69 PU, p< 0.005) cf-DNA and MPs significantly decreased (187.93 ± 115.81 vs. 121.28 ± 78.98 pg/ml, p<0.01, and 69.60 ± 62.60 vs. 39.82 ± 22.14 U/μL, p<0.05, respectively) and VEGF levels increased (585.02 ± 246.06 vs. 641.11 ± 212.69 pg/ml, p<0.05). These changes were higher in patients with more severe disease. There was a relationship between markers of damage (r = -0.53, p<0.005) but not between markers of damage and restoration, thus suggesting that both types of markers should be measured together. CONCLUSIONS: CPAP therapy improves FMD. This improvement may be related to an increase of endothelial restoration process and a decrease of endothelial damage

Distribution and origin of natural gas leakage in the Colorado Basin, offshore Argentina Margin, South America : seismic interpretation and 3D basin modelling

The detailed analysis of a dense 2D seismic reflection dataset and data from 8 exploration wells, allowed us to identify, map out and characterize possible indications of past and present-day hydrocarbon leakage (i.e. gas chimneys, gas pockets, and seafloor mounds and pockmarks) on the continental shelf and slope of the Colorado Basin, offshore Argentina, where Permian, Jurassic and Early Cretaceous source rocks are potentially present and may be currently mature. Identified gas leakage features, developed both in the syn-rift and post-rift successions, were also analysed in relation to the structural the stratigraphic elements of the basin. A family of seabed pockmarks, located close to an array of submarine channels, was identified on the distal slope of the basin. These pockmarks are overlying a series of sub-vertical to vertical seismic chimneys in the subsurface. A calibrated basin-wide 3D petroleum system model comprising generation and migration of hydrocarbons was carried out and compared with the observations from the seismic analysis. Preliminary results from this model indicate that although synrift and early Cretaceous source rock (SR) intervals may be depleted in the central areas of the basin, an active kitchen from the Aptian SR may be present below the slope areas. Hydrocarbon migration pathways predicted by the 3D model (Hybrid method) coincide with the interpreted seismic chimneys underlying the observed seabed slope pockmarks. Hence, our results indicate that thermogenic gas may be currently generated in the distal slope of the basin from mature early post-rift source rocks within the Early Cretaceous (Aptian) sequences and migrates vertically, due to seal failure, through the stratigraphic column. This migrating thermogenic gas is feeding the seafloor pockmarks identified in the distal slope of the basin, although up-dip lateral migration along stratigraphic layers to the more proximal slope areas cannot be ruled out. The present work represents the first published study integrating detailed seismic analysis and 3D basin modelling linking observed gas-leakage indicators and associated seepage pathways, to their relative abundance, distribution and feeding systems offshore Argentina's continental margin