The Cosmology Large Angular Scale Surveyor

The Cosmology Large Angular Scale Surveyor (CLASS) is a four telescope array designed to characterize relic primordial gravitational waves from inflation and the optical depth to reionization through a measurement of the polarized cosmic microwave background (CMB) on the largest angular scales. The frequencies of the four CLASS telescopes, one at 38 GHz, two at 93 GHz, and one dichroic system at 145/217 GHz, are chosen to avoid spectral regions of high atmospheric emission and span the minimum of the polarized Galactic foregrounds: synchrotron emission at lower frequencies and dust emission at higher frequencies. Low-noise transition edge sensor detectors and a rapid front-end polarization modulator provide a unique combination of high sensitivity, stability, and control of systematics. The CLASS site, at 5200 m in the Chilean Atacama desert, allows for daily mapping of up to 70\% of the sky and enables the characterization of CMB polarization at the largest angular scales. Using this combination of a broad frequency range, large sky coverage, control over systematics, and high sensitivity, CLASS will observe the reionization and recombination peaks of the CMB E- and B-mode power spectra. CLASS will make a cosmic variance limited measurement of the optical depth to reionization and will measure or place upper limits on the tensor-to-scalar ratio, $r$, down to a level of 0.01 (95\% C.L.)

Testing CMB Anomalies in E-mode Polarization with Current and Future Data

In this paper, we explore the power of the cosmic microwave background (CMB) polarization (E-mode) data to corroborate four potential anomalies in CMB temperature data: the lack of large angular-scale correlations, the alignment of the quadrupole and octupole (Q-O), the point-parity asymmetry, and the hemispherical power asymmetry. We use CMB simulations with noise representative of three experiments -- the Planck satellite, the Cosmology Large Angular Scale Surveyor (CLASS), and the LiteBIRD satellite -- to test how current and future data constrain the anomalies. We find the correlation coefficients $\rho$ between temperature and E-mode estimators to be less than $0.1$, except for the point-parity asymmetry ($\rho=0.17$ for cosmic-variance-limited simulations), confirming that E-modes provide a check on the anomalies that is largely independent of temperature data. Compared to Planck component-separated CMB data (SMICA), the putative LiteBIRD survey would reduce errors on E-mode anomaly estimators by factors of $\sim 3$ for hemispherical power asymmetry and point-parity asymmetry, and by $\sim 26$ for lack of large-scale correlation. The improvement in Q-O alignment is not obvious due to large cosmic variance, but we found the ability to pin down the estimator value will be improved by a factor $\gtrsim100$. Improvements with CLASS are intermediate to these.Comment: 23 pages, 15 figures, 6 table

Control and systems software for the Cosmology Large Angular Scale Surveyor (CLASS)

The Cosmology Large Angular Scale Surveyor (CLASS) is an array of polarization-sensitive millimeter wave telescopes that observes ~70% of the sky at frequency bands centered near 40GHz, 90GHz, 150GHz, and 220GHz from the Atacama desert of northern Chile. Here, we describe the architecture of the software used to control the telescopes, acquire data from the various instruments, schedule observations, monitor the status of the instruments and observations, create archival data packages, and transfer data packages to North America for analysis. The computer and network architecture of the CLASS observing site is also briefly discussed. This software and architecture has been in use since 2016, operating the telescopes day and night throughout the year, and has proven successful in fulfilling its design goals.Comment: 19 pages, 8 figures, to appear in Proc. SPI

CLASS Observations of Atmospheric Cloud Polarization at Millimeter Wavelengths

The dynamic atmosphere imposes challenges to ground-based cosmic microwave background observation, especially for measurements on large angular scales. The hydrometeors in the atmosphere, mostly in the form of clouds, scatter the ambient thermal radiation and are known to be the main linearly polarized source in the atmosphere. This scattering-induced polarization is significantly enhanced for ice clouds due to the alignment of ice crystals under gravity, which are also the most common clouds seen at the millimeter-astronomy sites at high altitudes. This work presents a multifrequency study of cloud polarization observed by the Cosmology Large Angular Scale Surveyor (CLASS) experiment on Cerro Toco in the Atacama Desert of northern Chile, from 2016 to 2022, at the frequency bands centered around 40, 90, 150, and 220 GHz. Using a machine-learning-assisted cloud classifier, we made connections between the transient polarized emission found in all four frequencies with the clouds imaged by monitoring cameras at the observing site. The polarization angles of the cloud events are found to be mostly $90^\circ$ from the local meridian, which is consistent with the presence of horizontally aligned ice crystals. The 90 and 150 GHz polarization data are consistent with a power law with a spectral index of $3.90\pm0.06$, while an excess/deficit of polarization amplitude is found at 40/220 GHz compared with a Rayleigh scattering spectrum. These results are consistent with Rayleigh-scattering-dominated cloud polarization, with possible effects from supercooled water absorption and/or Mie scattering from a population of large cloud particles that contribute to the 220 GHz polarization.Comment: 16 pages, 14 figures, submitted to Ap

Microwave Observations of Venus with CLASS

We report on the disk-averaged absolute brightness temperatures of Venus measured at four microwave frequency bands with the Cosmology Large Angular Scale Surveyor (CLASS). We measure temperatures of 432.3 $\pm$ 2.8 K, 355.6 $\pm$ 1.3 K, 317.9 $\pm$ 1.7 K, and 294.7 $\pm$ 1.9 K for frequency bands centered at 38.8, 93.7, 147.9, and 217.5 GHz, respectively. We do not observe any dependence of the measured brightness temperatures on solar illumination for all four frequency bands. A joint analysis of our measurements with lower frequency Very Large Array (VLA) observations suggests relatively warmer ($\sim$ 7 K higher) mean atmospheric temperatures and lower abundances of microwave continuum absorbers than those inferred from prior radio occultation measurements.Comment: 10 pages, 3 figures, published in PS

Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways

Triple negative breast cancer (TNBC) patients have high risk of recurrence and metastasis, and current treatment options remain limited. Cancer stem-like cells (CSCs) have been linked to cancer initiation, progression and chemotherapy resistance. Notch signaling is a key pathway regulating TNBC CSC survival. Treatment of TNBC with PI3K or mTORC1/2 inhibitors results in drug-resistant, Notch-dependent CSC. However, downstream mechanisms and potentially druggable Notch effectors in TNBC CSCs are largely unknown. We studied the role of the AKT pathway and mitochondrial metabolism downstream of Notch signaling in TNBC CSC from cell lines representative of different TNBC molecular subtypes as well as a novel patient-derived model. We demonstrate that exposure of TNBC cells to recombinant Notch ligand Jagged1 leads to rapid AKT phosphorylation in a Notch1-dependent but RBP-Jκ independent fashion. This requires mTOR and IKKα. Jagged1 also stimulates mitochondrial respiration and fermentation in an AKT- and IKK-dependent fashion. Notch1 co-localizes with mitochondria in TNBC cells. Pharmacological inhibition of Notch cleavage by gamma secretase inhibitor PF-03084014 in combination with AKT inhibitor MK-2206 or IKK-targeted NF-κB inhibitor Bay11-7082 blocks secondary mammosphere formation from sorted CD90hi or CD44+CD24low (CSCs) cells. A TNBC patient-derived model gave comparable results. Besides mitochondrial oxidative metabolism, Jagged1 also triggers nuclear, NF-κB-dependent transcription of anti-apoptotic gene cIAP-2. This requires recruitment of Notch1, IKKα and NF-κB to the cIAP-2 promoter. Our observations support a model where Jagged1 triggers IKKα-dependent, mitochondrial and nuclear Notch1 signals that stimulate AKT phosphorylation, oxidative metabolism and transcription of survival genes in PTEN wild-type TNBC cells. These data suggest that combination treatments targeting the intersection of the Notch, AKT and NF-κB pathways have potential therapeutic applications against CSCs in TNBC cases with Notch1 and wild-type PTEN expression

CLASS Angular Power Spectra and Map-Component Analysis for 40 GHz Observations through 2022

Measurement of the largest angular scale ($\ell < 30$) features of the cosmic microwave background (CMB) polarization is a powerful way to constrain the optical depth to reionization, $\tau$, and search for the signature of inflation through the detection of primordial $B$-modes. We present an analysis of maps covering nearly 75% of the sky made from the ground-based $40\,\mathrm{GHz}$ channel of the Cosmology Large Angular Scale Surveyor (CLASS) from August 2016 to May 2022. Using fast front-end polarization modulation from the Atacama Desert in Chile, we show this channel achieves higher sensitivity than the analogous frequencies from satellite measurements in the range $10 < \ell < 100$. After a final calibration adjustment, noise simulations show the CLASS linear (circular) polarization maps have a white noise level of $125 \,(130)\,\mathrm{\mu K\, arcmin}$. We measure the Galaxy-masked $EE$ and $BB$ spectra of diffuse synchrotron radiation and compare to space-based measurements at similar frequencies. In combination with external data, we expand measurements of the spatial variations of the synchrotron spectral energy density (SED) to include new regions of the sky and measure the faint diffuse SED in the harmonic domain. We place a new upper limit on a background of circular polarization in the range $5 < \ell < 125$ with the first bin showing $D_\ell < 0.023$ $\mathrm{\mu K^2_{CMB}}$ at 95% confidence. These results establish a new standard for recovery of the largest-scale CMB polarization from the ground and signal exciting possibilities when the higher sensitivity and higher frequency CLASS channels are included in the analysis.Comment: 36 pages, 24 figures, 6 tables. Submitted to The Astrophysical Journa

Venus Observations at 40 and 90 GHz with CLASS

Using the Cosmology Large Angular Scale Surveyor, we measure the disk-averaged absolute Venus brightness temperature to be 432.3 $\pm$ 2.8 K and 355.6 $\pm$ 1.3 K in the Q and W frequency bands centered at 38.8 and 93.7 GHz, respectively. At both frequency bands, these are the most precise measurements to date. Furthermore, we observe no phase dependence of the measured temperature in either band. Our measurements are consistent with a CO$_2$-dominant atmospheric model that includes trace amounts of additional absorbers like SO$_2$ and H$_2$SO$_4$.Comment: 7 pages, 3 figures, published in PS