Hanford`s commonly used containers; treatment, storage, and disposal volumes

This document is a compilation of container information and describes the standard waste containers that will be used for shipment to the Central Waste Complex. It is to be used as a guideline for waste generators when reporting forecasted external/internal volume capacities and should be used by solid waste facility planners for planning/analysis. It will also ensure consistency in container descriptions

Convergence of equilibria for numerical approximations of a suspension model

In this paper we study the numerical approximations of a non-Newtonian model for concentratedsuspensions. First,weprovethattheapproximativemodelspossessauniquefixedpointandstudy theirconvergencetoastationarypointoftheoriginalequation. Second, we implement an implicit Euler scheme, proving the convergence of these approximationsaswell. Finally,numericalsimulationsareprovided

Gut microbiota in canine idiopathic epilepsy: Effects of disease and treatment

Epilepsy is one of the most common neurological disorders in humans and dogs. The structure and composition of gut microbiome associated to this disorder has not yet been analyzed in depth but there is evidence that suggests a possible influence of gut bacteria in controlling seizures. The aim of this study was to investigate the changes in gut microbiota associated to canine idiopathic epilepsy (IE) and the possible influence of antiepileptic drugs (AEDs) on the modulation of this microbiota. Faecal microbiota composition was analyzed using sequencing of bacterial 16S rRNA gene in a group of healthy controls (n = 12) and a group of epileptic dogs both before (n = 10) and after a 30-day single treatment with phenobarbital or imepitoin (n = 9). Epileptic dogs showed significantly reduced abundance of GABA (Pseudomonadales, Pseudomonadaceae, Pseudomonas and Pseudomona_graminis) and SCFAs-producing bacteria (Peptococcaceae, Ruminococcaceae and Anaerotruncus) as well as bacteria associated with reduced risk for brain disease (Prevotellaceae) than control dogs. The administration of AEDs during 30 days did not modify the gut microbiota composition. These results are expected to contribute to the understanding of canine idiopathic epilepsy and open up the possibility of studying new therapeutic approaches for this disorder, including probiotic intervention to restore gut microbiota in epileptic individuals. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Event selection for dynamical downscaling: a neural network approach for physically-constrained precipitation events

This study presents a new dynamical downscaling strategy for extreme events. It is based on a combination of statistical downscaling of coarsely resolved global model simulations and dynamical downscaling of specific extreme events constrained by the statistical downscaling part. The method is applied to precipitation extremes over the upper Aare catchment, an area in Switzerland which is characterized by complex terrain. The statistical downscaling part consists of an Artificial Neural Network (ANN) framework trained in a reference period. Thereby, dynamically downscaled precipitation over the target area serve as predictands and large-scale variables, received from the global model simulation, as predictors. Applying the ANN to long term global simulations produces a precipitation series that acts as a surrogate of the dynamically downscaled precipitation for a longer climate period, and therefore are used in the selection of events. These events are then dynamically downscaled with a regional climate model to 2 km. The results show that this strategy is suitable to constraint extreme precipitation events, although some limitations remain, e.g., the method has lower efficiency in identifying extreme events in summer and the sensitivity of extreme events to climate change is underestimated

High efficacy and low toxicity of weekly docetaxel given as first-line treatment for metastatic breast cancer

Background: Docetaxel is one of the most effective antitumor agents currently available for the treatment of metastatic breast cancer (MBC). This phase II multicenter study prospectively analyzed the efficacy and toxicity of docetaxel given on a weekly schedule as first-line treatment of metastatic breast cancer. Patients and Methods: All patients received docetaxel, 35 mg/m(2) weekly for 6 weeks, followed by 2 weeks of rest. Subsequent cycles ( 3 weeks of treatment, 2 weeks of rest) were given until a maximum of 5 cycles or disease progression. Premedication consisted of 8 mg dexamethasone intravenously 30 min prior to the infusion of docetaxel. Results: Fifty-four patients at a median age of 58 years with previously untreated MBC were included in the study. A median of 10 doses ( median cumulative dose 339 mg/m(2)) was administered ( range: 2 - 18). The overall response rate was 48.1% ( 95% CI: 34 - 61%, intent-to-treat). Median survival was 15.8 months and median time to progression was 5.9 months ( intent-to-treat). Hematological toxicity was mild with absence of neutropenia-related complications. Grade 3 neutropenia was observed in 3.7% of patients and grade 3 and 4 anemia was observed in 5.6 and 1.9% of patients, respectively. Conclusion: The weekly administration of docetaxel is highly efficient and safe as first-line treatment for MBC and may serve as an important treatment option specifically in elderly patients and patients with a reduced performance status. Copyright (C) 2005 S. Karger AG, Basel

Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells

We are grateful to Medical Research Scotland (PHD-1046-2016) for funding and a joint Cancer Research UK (A28596) and The Brain Tumour Charity award (GN-000676) to N. O. C. T. V. thanks EU Horizon 2020 research and innovation programme under the Marie Skls PHD-1046-2016Medical Research Scotland A28596Cancer Research UK GN-000676Brain Tumour Charity award 749299European Union (EU)MS

Математическая модель процесса формирования и сохранения коллективных знаний

На основі запропонованої системи аксіом побудовано та досліджено математичну модель процесу формування та збереження знань у великих освітніх системах. Знайдено умови збереження на деякому часовому проміжку заданого гарантованого рівня колективних знань.Based on the introduced system of axioms, a mathematical model for forming and process of preserving collective knowledge in large educational systems is constructed and investigated. The conditions for preserving a guaranteed level of collective knowledge are defined.На основе предложенной системы аксиом построена и исследована математическая модель процесса формирования и сохранения знаний в больших образовательных системах. Определены условия на некотором временном промежутке заданного гарантированного уровня коллективных знаний

Digestibility of Duddingtonia flagrans chlamydospores in ruminants: in vitro and in vivo studies

<p>Abstract</p> <p>Background</p> <p>The use of <it>Duddingtonia flagrans </it>as a tool for the biological control of gastrointestinal nematodes (GIN) is a promising alternative to anthelmintics. The chlamydospores of <it>D. flagrans </it>are orally dosed and their thick cell wall gives them the capacity to resist digestion and pass through the gastrointestinal tract (GIT). Chlamydospores reaching the faeces are able to germinate and trap nematode larvae. The efficacy of this control method is based on reducing the numbers of infective larvae leaving the faeces. Techniques have recently been developed for quantifying the numbers of chlamydospores in faeces. As the number of non-digested spores could be relevant in the design and optimization of dosing programmes for the control of GIN infective larvae, the aim of the present study was to estimate the loss of <it>D. flagrans </it>chlamydospores during their passage through the ruminant gastrointestinal tract using <it>in vitro </it>and <it>in vivo </it>techniques.</p> <p>Results</p> <p>After <it>in vitro </it>rumen digestion, chlamydospore recovery was not different from the quantity originally incubated (undigested spores) (P > 0.05). <it>In vitro </it>rumen+abomasum digestion caused nearly 36% loss of the chlamydospores originally incubated (P < 0.05). Germination of chlamydospores classified as viable was 24.3%. Chlamydospores classified as non-viable did not germinate. Rumen digestion resulted in more spore germination (R1 = 35.7% and R2 = 53.3%) compared to no digestion (time 0 h = 8.7%). Subsequent abomasal digestion reduced germination (R1+A = 25%) or stopped it (R2+A = 0%). <it>In vivo </it>apparent chlamydospore digestibility in sheep showed a loss of 89.7% of the chlamydospores (P < 0.05).</p> <p>Conclusions</p> <p>The loss of chlamydospores was evident under <it>in vitro </it>and <it>in vivo </it>conditions. Negligible amounts of spores were lost during the <it>in vitro </it>rumen digestion. However, <it>in vitro </it>rumen+abomasum digestion resulted in a chlamydospore loss of approximately 36%. <it>In vivo </it>passage through the sheep GIT resulted in a total loss of 89.7% of the orally administered spores.</p