Similar Levels of Disease Severity Correspond to a Greater Burden of Illness in Women Compared with Men with Hidradenitis Suppurativa

Abstract is missing (Short communication

TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.

We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell-interacting, activating receptor on myeloid cells-1 (TARM1). The transmembrane region of TARM1 contained a conserved arginine residue, consistent with association with a signaling adaptor. TARM1 associated with the ITAM adaptor FcRγ but not with DAP10 or DAP12. In healthy mice, TARM1 is constitutively expressed on the cell surface of mature and immature CD11b(+)Gr-1(+) neutrophils within the bone marrow. Following i.p. LPS treatment or systemic bacterial challenge, TARM1 expression was upregulated by neutrophils and inflammatory monocytes and TARM1(+) cells were rapidly recruited to sites of inflammation. TARM1 expression was also upregulated by bone marrow-derived macrophages and dendritic cells following stimulation with TLR agonists in vitro. Ligation of TARM1 receptor in the presence of TLR ligands, such as LPS, enhanced the secretion of proinflammatory cytokines by macrophages and primary mouse neutrophils, whereas TARM1 stimulation alone had no effect. Finally, an immobilized TARM1-Fc fusion protein suppressed CD4(+) T cell activation and proliferation in vitro. These results suggest that a putative T cell ligand can interact with TARM1 receptor, resulting in bidirectional signaling and raising the T cell activation threshold while costimulating the release of proinflammatory cytokines by macrophages and neutrophils.This work was supported by grants from the Cancer Research UK, the Wellcome Trust, Medical Research Council, UK, and a Marie Curie International Outgoing Fellowship awarded to A.D.B. with additional support from the Wellcome Trust and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre.This is the author accepted manuscript. The final version is available from the American Association of Immunologists via http://dx.doi.org/10.4049/jimmunol.140184

RANGER: Radars and Early Warning Technologies for Long Distance Maritime Surveillance

In this paper, we present a high-level view of RANGER, a novel platform that combines innovative radar technologies with cutting edge technological solutions for early warning, in view of delivering a surveillance platform offering detection, recognition, identification and tracking of suspicious vessels, i.e. capabilities that exceed those of current radar systems. The RANGER platform consists of two radar technologies, a novel Over-The-Horizon (OTH) Radar combined with a Multiple- input and Multiple-output Radar (MIMO) implemented exploiting the latest photonics advancements, a Uniform Communication Gateway (UCG) for seamless, secure and interoperable integration of radars and legacy systems, an Early Warning System (EWS) exploiting data fusion and deep and adaptable machine learning schemes able to automatically detect radar targets and produce early warnings, an Advanced User Interface (AUI) for visualization of the maritime operational picture, and a Common Information Sharing Environment (CISE) gateway adapter for sharing information with the CISE network. The RANGER system aims at significantly progressing the accuracy and long distance detection, identification and recognition rates as well as improving the provision of early warnings and alerts related to maritime operations, thus drastically improving the response and intervention capacity of related European services

Delirium in nursing home residents: is there a role of antidepressants? A cross sectional study.

Background: Delirium is strongly associated with poor health outcomes, yet it is frequently underdiagnosed. Limited research on delirium has been conducted in Nursing Homes (NHs). Our aim is to assess delirium prevalence and its associated factors, in particular pharmacological prescription, in this care setting. Methods: Data from the Italian "Delirium Day" 2016 Edition, a national multicenter point-prevalence study on patients aged 65 and older were analyzed to examine the associations between the prevalence of delirium and its subtypes with demographics and information about medical history and pharmacological treatment. Delirium was assessed using the Assessment test for delirium and cognitive impairment (4AT). Motor subtype was evaluated using the Delirium Motor Subtype Scale (DMSS). Results: 955 residents, from 32 Italian NHs with a mean age of 84.72 ± 7.78 years were included. According to the 4AT, delirium was present in 260 (27.2%) NHs residents, mainly hyperactive (35.4%) or mixed subtypes (20.7%). Antidepressant treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with lower delirium prevalence in univariate and multivariate analyses. Conclusions: The high prevalence of delirium in NHs highlights the need to systematically assess its occurrence in this care settings. The inverse association between SSRIs and delirium might imply a possible preventive role of this class of therapeutic agents against delirium in NHs, yet further studies are warranted to ascertain any causal relationship between SSRIs intake and reduced delirium incidence

Melanoma and immunotherapy bridge 2015

Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunoscore task force: an update K15 The immunoscore in colorectal cancer highlights the importance of digital scoring systems in surgical pathology Tilman Rau, Alessandro Lugli K16 The immunoscore: toward an integrated immunomonitoring from the diagnosis to the follow up of cancer’s patients Franck Pagès Economic sustainability of melanoma treatments: regulatory, health technology assessment and market access issues K17 Nivolumab, the regulatory experience in immunotherapy Jorge Camarero, Arantxa Sancho K18 Evidence to optimize access for immunotherapies Claudio Jommi ORAL PRESENTATIONS Molecular and immuno-advances O1 Ipilimumab treatment results in CD4 T cell activation that is concomitant with a reduction in Tregs and MDSCs Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe V. Masucci, Johan Hansson, Rolf Kiessling O2 Evaluation of prognostic and therapeutic potential of COX-2 and PD-L1 in primary and metastatic melanoma Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’alterio, Angela Ianaro, Giuseppe Cirino, Paolo Antonio Ascierto, Giuseppina Liguori, Gerardo Botti O3 Vemurafenib in patients with BRAFV600 mutation–positive metastatic melanoma: final overall survival results of the BRIM-3 study Paul B. Chapman, Caroline Robert, James Larkin, John B. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Paolo Antonio Ascierto, Alessandro Testori, Paul Lorigan, Reinhard Dummer, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur O4 Updated survival, response and safety data in a phase 1 dose-finding study (CA209-004) of concurrent nivolumab (NIVO) and ipilimumab (IPI) in advanced melanoma Mario Sznol, Margaret K. Callahan, Harriet Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander Lesokhin, Michael B. Atkins, John M. Kirkwood, Matthew M. Burke, Amanda Ralabate, Angel Rivera, Stephanie A. Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine Horak, Joel Jiang, Jedd Wolchok Combination therapies O5 Efficacy and correlative biomarker analysis of the coBRIM study comparing cobimetinib (COBI) + vemurafenib (VEM) vs placebo (PBO) + VEM in advanced BRAF-mutated melanoma patients (pts) Paolo A. Ascierto, Grant A. McArthur, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Antoni Ribas, Brigitte Dréno O6 Preliminary clinical safety, tolerability and activity results from a Phase Ib study of atezolizumab (anti-PDL1) combined with vemurafenib in BRAFV600-mutant metastatic melanoma Ryan Sullivan, Omid Hamid, Manish Patel, Stephen Hodi, Rodabe Amaria, Peter Boasberg, Jeffrey Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, Patrick Hwu O7 Preliminary safety and efficacy data from a phase 1/2 study of epacadostat (INCB024360) in combination with pembrolizumab in patients with advanced/metastatic melanoma Thomas F. Gajewski, Omid Hamid, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani S. Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma Reinhard Dummer, Georgina V. Long, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy, Anthony J. Olszanski, Thomas F. Gajewski, John M. Kirkwood, Christine Gause, Lisa Chen, David R. Kaufman, Jeffrey Chou, F. Stephen Hodi News in immunotherapy O9 Two-year survival and safety update in patients (pts) with treatment-naïve advanced melanoma (MEL) receiving nivolumab (NIVO) or dacarbazine (DTIC) in CheckMate 066 Victoria Atkinson, Paolo A. Ascierto, Georgina V. Long, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Celeste Lebbé, Lars Ny, Matias Chacon, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Luis De La Cruz-Merino, Gil Bar-Sela, Christine Horak, Joel Jiang, Helene Hardy, Caroline Robert O10 Efficacy and safety of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL) who were treated beyond progression in CheckMate 066/067 Georgina V. Long, Jeffrey S. Weber, James Larkin, Victoria Atkinson, Jean-Jacques Grob, Reinhard Dummer, Caroline Robert, Ivan Marquez-Rodas, Catriona McNeil, Henrik Schmidt, Karen Briscoe, Jean-François Baurain, F. Stephen Hodi, Jedd D. Wolchok Tumor microenvironment and biomarkers O11 New biomarkers for response/resistance to BRAF inhibitor therapy in metastatic melanoma Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi O12 Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma and response to ipilimumab Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, Carolin Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vetizou, Romain Daillere, Vichnou Poirier-Colame, Michaëla Semeraro, Anne Caignard, Craig L Slingluff Jr, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Jedd Wolchok, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel O13 Serum levels of PD1- and CD28-positive exosomes before Ipilimumab correlate with therapeutic response in metastatic melanoma patients Passarelli Anna, Tucci Marco, Stucci Stefania, Mannavola Francesco, Capone Mariaelena, Madonna Gabriele, Ascierto Paolo Antonio, Silvestris Franco O14 Immunological prognostic factors in stage III melanomas María Paula Roberti, Nicolas Jacquelot, David P Enot, Sylvie Rusakiewicz, Michaela Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Caroline Robert, Christophe Borg, Benjamin Weide, François Aubin, Stéphane Dalle, Michele Maio, Jedd D. Wolchok, Holbrook Kohrt, Maha Ayyoub, Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel POSTER PRESENTATIONS Molecular and immuno-advances P1 Human melanoma cells resistant to B-RAF and MEK inhibition exhibit mesenchymal-like features Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Paolo A. Ascierto, Emilia Caputo P2 Anti-proliferative and pro-apoptotic effect of ABT888 on melanoma cell lines and its potential role in the treatment of melanoma resistant to B-RAF inhibitors Federica Fratangelo, Rosa Camerlingo, Emilia Caputo, Maria Letizia Motti, Rosaria Falcone, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Maria Vincenza Carriero, Giuseppe Pirozzi and Paolo Antonio Ascierto P3 Involvement of the L-cysteine/CSE/H2S pathway in human melanoma progression Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Rosa Camerlingo, Giuseppe Pirozzi, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro P4 Cancer stem cell antigen revealing pattern of antibody variable region genes were defined by immunoglobulin repertoire analysis in patients with malignant melanoma Beatrix Kotlan, Gabriella Liszkay, Miri Blank, Timea Balatoni, Judit Olasz, Emil Farkas, Andras Szollar, Akos Savolt, Maria Godeny, Orsolya Csuka, Szabolcs Horvath, Klara Eles, Yehuda Shoenfeld and Miklos Kasler P5 Upregulation of Neuregulin-1 expression is a hallmark of adaptive response to BRAF/MEK inhibitors in melanoma Debora Malpicci, Luigi Fattore, Susan Costantini, Francesca Capone, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto P6 HuR positively regulates migration of HTB63 melanoma cells Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad P7 Prolyl 4- (C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Harwood, Alastair Thompson, Tim Crook P8 Urokinase receptor antagonists: novel agents for the treatment of melanoma Maria Letizia Motti, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Federica Fratangelo, Antonello Pessi, Gennaro Ciliberto, Paolo Antonio Ascierto, Maria Vincenza Carriero P9 Exosomes released by melanoma cell lines enhance chemotaxis of primary tumor cells Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris P10 New insights in mitochondrial metabolic reprogramming in melanoma Anna Ferretta, Gabriella Guida, Stefania Guida, Imma Maida, Tiziana Cocco, Sabino Strippoli, Stefania Tommasi, Amalia Azzariti, Michele Guida P11 Lenalidomide restrains the proliferation in melanoma cells through a negative regulation of their cell cycle Stella D’Oronzo, Anna Passarelli, Claudia Felici, Marco Tucci, Davide Quaresmini, Franco Silvestris Combination therapies P12 Chemoimmunotherapy elicits polyfunctional anti-tumor CD8 + T cells depending on the activation of an AKT pathway sustained by ICOS Ornella Franzese, Belinda Palermo, Cosmo Di Donna, Isabella Sperduti, MariaLaura Foddai, Helena Stabile, Angela Gismondi, Angela Santoni, Paola Nisticò P13 Favourable toxicity profile of combined BRAF and MEK inhibitors in metastatic melanoma patients Andrea P. Sponghini, Francesca Platini, Elena Marra, David Rondonotti, Oscar Alabiso, Maria T. Fierro, Paola Savoia, Florian Stratica, Pietro Quaglino P14 Electrothermal bipolar vessel sealing system dissection reduces seroma output or time to drain removal following axillary and ilio-inguinal node dissection in melanoma patients: a pilot study Di Monta Gianluca, Caracò Corrado, Di Marzo Massimiliano, Marone Ugo, Di Cecilia Maria Luisa, Mozzillo Nicola News in immunotherapy P15 Clinical and immunological response to ipilimumab in a metastatic melanoma patient with HIV infection Francesco Sabbatino, Celeste Fusciello1, Antonio Marra, Rosario Guarrasi, Carlo Baldi, Rosa Russo, Di Giulio Giovanni, Vincenzo Faiola, Pio Zeppa, Stefano Pepe P16 Immunotherapy and hypophysitis: a case report Elisabetta Gambale, Consiglia Carella, Alessandra Di Paolo, Michele De Tursi Tumor microenvironment and biomarkers P17 New immuno- histochemical markers for the differential diagnosis of atypical melanocytic lesions with uncertain malignant potential Laura Marra, Giosuè Scognamiglio, Monica Cantile, Margherita Cerrone, Fara De Murtas, Valeria Sorrentino, Anna Maria Anniciello, Gerardo Botti P18 Utility of simultaneous measurement of three serum tumor markers in melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P19 The significance of various cut-off levels of melanoma inhibitory activity in evaluation of cutaneous melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P20 The long noncoding RNA HOTAIR is associated to metastatic progression of melanoma and it can be identified in the blood of patients with advanced disease Chiara Botti, Giosuè Scognamiglio, Laura Marra, Gabriella Aquino, Rosaria Falcone, Annamaria Anniciello, Paolo Antonio Ascierto, Gerardo Botti, Monica Cantile Other P21 The effect of Sentinel Lymph Node Biopsy in melanoma mortality: timing of dissection Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi P22 Epidemiological survey on related psychopathology in melanoma Valeria De Biasio, Vincenzo C. Battarra IMMUNOTHERAPY BRIDGE KEYNOTE SPEAKER PRESENTATIONS Immunotherapy beyond melanoma K19 Predictor of response to radiation and immunotherapy Silvia Formenti K20 Response and resistance to PD-1 pathway blockade: clues from the tumor microenvironment Maria Libera Ascierto, Tracee L. McMiller, Alan E. Berger, Ludmila Danilova, Robert A. Anders, George J. Netto, Haiying Xu, Theresa S. Pritchard, Jinshui Fan, Chris Cheadle, Leslie Cope, Charles G. Drake, Drew M. Pardoll, Janis M. Taube and Suzanne L. Topalian K21 Combination immunotherapy with autologous stem cell transplantation, protein immunization, and PBMC reinfusion in myeloma patients Sacha Gnjatic, Sarah Nataraj, Naoko Imai, Adeeb Rahman, Achim A. Jungbluth, Linda Pan, Ralph Venhaus, Andrew Park, Frédéric F. Lehmann, Nikoletta Lendvai, Adam D. Cohen, and Hearn J. Cho K22 Anti-cancer immunity despite T cell “exhaustion” Speiser Daniel Immunotherapy in oncology (I-O): data from clinical trial K23 The Checkpoint Inhibitors for the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) Vera Hirs

Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015

Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunoscore task force: an update K15 The immunoscore in colorectal cancer highlights the importance of digital scoring systems in surgical pathology Tilman Rau, Alessandro Lugli K16 The immunoscore: toward an integrated immunomonitoring from the diagnosis to the follow up of cancer’s patients Franck Pagès Economic sustainability of melanoma treatments: regulatory, health technology assessment and market access issues K17 Nivolumab, the regulatory experience in immunotherapy Jorge Camarero, Arantxa Sancho K18 Evidence to optimize access for immunotherapies Claudio Jommi ORAL PRESENTATIONS Molecular and immuno-advances O1 Ipilimumab treatment results in CD4 T cell activation that is concomitant with a reduction in Tregs and MDSCs Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe V. Masucci, Johan Hansson, Rolf Kiessling O2 Evaluation of prognostic and therapeutic potential of COX-2 and PD-L1 in primary and metastatic melanoma Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’alterio, Angela Ianaro, Giuseppe Cirino, Paolo Antonio Ascierto, Giuseppina Liguori, Gerardo Botti O3 Vemurafenib in patients with BRAFV600 mutation–positive metastatic melanoma: final overall survival results of the BRIM-3 study Paul B. Chapman, Caroline Robert, James Larkin, John B. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Paolo Antonio Ascierto, Alessandro Testori, Paul Lorigan, Reinhard Dummer, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur O4 Updated survival, response and safety data in a phase 1 dose-finding study (CA209-004) of concurrent nivolumab (NIVO) and ipilimumab (IPI) in advanced melanoma Mario Sznol, Margaret K. Callahan, Harriet Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander Lesokhin, Michael B. Atkins, John M. Kirkwood, Matthew M. Burke, Amanda Ralabate, Angel Rivera, Stephanie A. Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine Horak, Joel Jiang, Jedd Wolchok Combination therapies O5 Efficacy and correlative biomarker analysis of the coBRIM study comparing cobimetinib (COBI) + vemurafenib (VEM) vs placebo (PBO) + VEM in advanced BRAF-mutated melanoma patients (pts) Paolo A. Ascierto, Grant A. McArthur, James Larkin, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, Luc Thomas, Luis de la Cruz-Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Antoni Ribas, Brigitte Dréno O6 Preliminary clinical safety, tolerability and activity results from a Phase Ib study of atezolizumab (anti-PDL1) combined with vemurafenib in BRAFV600-mutant metastatic melanoma Ryan Sullivan, Omid Hamid, Manish Patel, Stephen Hodi, Rodabe Amaria, Peter Boasberg, Jeffrey Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, Patrick Hwu O7 Preliminary safety and efficacy data from a phase 1/2 study of epacadostat (INCB024360) in combination with pembrolizumab in patients with advanced/metastatic melanoma Thomas F. Gajewski, Omid Hamid, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani S. Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar O8 Primary analysis of MASTERKEY-265 phase 1b study of talimogene laherparepvec (T-VEC) and pembrolizumab (pembro) for unresectable stage IIIB-IV melanoma Reinhard Dummer, Georgina V. Long, Antoni Ribas, Igor Puzanov, Olivier Michielin, Ari VanderWalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernandez, Josep Malvehy, Anthony J. Olszanski, Thomas F. Gajewski, John M. Kirkwood, Christine Gause, Lisa Chen, David R. Kaufman, Jeffrey Chou, F. Stephen Hodi News in immunotherapy O9 Two-year survival and safety update in patients (pts) with treatment-naïve advanced melanoma (MEL) receiving nivolumab (NIVO) or dacarbazine (DTIC) in CheckMate 066 Victoria Atkinson, Paolo A. Ascierto, Georgina V. Long, Benjamin Brady, Caroline Dutriaux, Michele Maio, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona McNeil, Ewa Kalinka-Warzocha, Celeste Lebbé, Lars Ny, Matias Chacon, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Luis De La Cruz-Merino, Gil Bar-Sela, Christine Horak, Joel Jiang, Helene Hardy, Caroline Robert O10 Efficacy and safety of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL) who were treated beyond progression in CheckMate 066/067 Georgina V. Long, Jeffrey S. Weber, James Larkin, Victoria Atkinson, Jean-Jacques Grob, Reinhard Dummer, Caroline Robert, Ivan Marquez-Rodas, Catriona McNeil, Henrik Schmidt, Karen Briscoe, Jean-François Baurain, F. Stephen Hodi, Jedd D. Wolchok Tumor microenvironment and biomarkers O11 New biomarkers for response/resistance to BRAF inhibitor therapy in metastatic melanoma Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi O12 Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma and response to ipilimumab Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, Carolin Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vetizou, Romain Daillere, Vichnou Poirier-Colame, Michaëla Semeraro, Anne Caignard, Craig L Slingluff Jr, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Jedd Wolchok, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel O13 Serum levels of PD1- and CD28-positive exosomes before Ipilimumab correlate with therapeutic response in metastatic melanoma patients Passarelli Anna, Tucci Marco, Stucci Stefania, Mannavola Francesco, Capone Mariaelena, Madonna Gabriele, Ascierto Paolo Antonio, Silvestris Franco O14 Immunological prognostic factors in stage III melanomas María Paula Roberti, Nicolas Jacquelot, David P Enot, Sylvie Rusakiewicz, Michaela Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Caroline Robert, Christophe Borg, Benjamin Weide, François Aubin, Stéphane Dalle, Michele Maio, Jedd D. Wolchok, Holbrook Kohrt, Maha Ayyoub, Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel POSTER PRESENTATIONS Molecular and immuno-advances P1 Human melanoma cells resistant to B-RAF and MEK inhibition exhibit mesenchymal-like features Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Paolo A. Ascierto, Emilia Caputo P2 Anti-proliferative and pro-apoptotic effect of ABT888 on melanoma cell lines and its potential role in the treatment of melanoma resistant to B-RAF inhibitors Federica Fratangelo, Rosa Camerlingo, Emilia Caputo, Maria Letizia Motti, Rosaria Falcone, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Maria Vincenza Carriero, Giuseppe Pirozzi and Paolo Antonio Ascierto P3 Involvement of the L-cysteine/CSE/H2S pathway in human melanoma progression Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Rosa Camerlingo, Giuseppe Pirozzi, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro P4 Cancer stem cell antigen revealing pattern of antibody variable region genes were defined by immunoglobulin repertoire analysis in patients with malignant melanoma Beatrix Kotlan, Gabriella Liszkay, Miri Blank, Timea Balatoni, Judit Olasz, Emil Farkas, Andras Szollar, Akos Savolt, Maria Godeny, Orsolya Csuka, Szabolcs Horvath, Klara Eles, Yehuda Shoenfeld and Miklos Kasler P5 Upregulation of Neuregulin-1 expression is a hallmark of adaptive response to BRAF/MEK inhibitors in melanoma Debora Malpicci, Luigi Fattore, Susan Costantini, Francesca Capone, Paolo Antonio Ascierto, Rita Mancini, Gennaro Ciliberto P6 HuR positively regulates migration of HTB63 melanoma cells Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad P7 Prolyl 4- (C-P4H) hydroxylases have opposing effects in malignant melanoma: implication in prognosis and therapy Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Harwood, Alastair Thompson, Tim Crook P8 Urokinase receptor antagonists: novel agents for the treatment of melanoma Maria Letizia Motti, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Federica Fratangelo, Antonello Pessi, Gennaro Ciliberto, Paolo Antonio Ascierto, Maria Vincenza Carriero P9 Exosomes released by melanoma cell lines enhance chemotaxis of primary tumor cells Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris P10 New insights in mitochondrial metabolic reprogramming in melanoma Anna Ferretta, Gabriella Guida, Stefania Guida, Imma Maida, Tiziana Cocco, Sabino Strippoli, Stefania Tommasi, Amalia Azzariti, Michele Guida P11 Lenalidomide restrains the proliferation in melanoma cells through a negative regulation of their cell cycle Stella D’Oronzo, Anna Passarelli, Claudia Felici, Marco Tucci, Davide Quaresmini, Franco Silvestris Combination therapies P12 Chemoimmunotherapy elicits polyfunctional anti-tumor CD8 + T cells depending on the activation of an AKT pathway sustained by ICOS Ornella Franzese, Belinda Palermo, Cosmo Di Donna, Isabella Sperduti, MariaLaura Foddai, Helena Stabile, Angela Gismondi, Angela Santoni, Paola Nisticò P13 Favourable toxicity profile of combined BRAF and MEK inhibitors in metastatic melanoma patients Andrea P. Sponghini, Francesca Platini, Elena Marra, David Rondonotti, Oscar Alabiso, Maria T. Fierro, Paola Savoia, Florian Stratica, Pietro Quaglino P14 Electrothermal bipolar vessel sealing system dissection reduces seroma output or time to drain removal following axillary and ilio-inguinal node dissection in melanoma patients: a pilot study Di Monta Gianluca, Caracò Corrado, Di Marzo Massimiliano, Marone Ugo, Di Cecilia Maria Luisa, Mozzillo Nicola News in immunotherapy P15 Clinical and immunological response to ipilimumab in a metastatic melanoma patient with HIV infection Francesco Sabbatino, Celeste Fusciello1, Antonio Marra, Rosario Guarrasi, Carlo Baldi, Rosa Russo, Di Giulio Giovanni, Vincenzo Faiola, Pio Zeppa, Stefano Pepe P16 Immunotherapy and hypophysitis: a case report Elisabetta Gambale, Consiglia Carella, Alessandra Di Paolo, Michele De Tursi Tumor microenvironment and biomarkers P17 New immuno- histochemical markers for the differential diagnosis of atypical melanocytic lesions with uncertain malignant potential Laura Marra, Giosuè Scognamiglio, Monica Cantile, Margherita Cerrone, Fara De Murtas, Valeria Sorrentino, Anna Maria Anniciello, Gerardo Botti P18 Utility of simultaneous measurement of three serum tumor markers in melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P19 The significance of various cut-off levels of melanoma inhibitory activity in evaluation of cutaneous melanoma patients Angela Sandru, Silviu Voinea, Eugenia Panaitescu, Madalina Bolovan, Adina Stanciu, Sabin Cinca P20 The long noncoding RNA HOTAIR is associated to metastatic progression of melanoma and it can be identified in the blood of patients with advanced disease Chiara Botti, Giosuè Scognamiglio, Laura Marra, Gabriella Aquino, Rosaria Falcone, Annamaria Anniciello, Paolo Antonio Ascierto, Gerardo Botti, Monica Cantile Other P21 The effect of Sentinel Lymph Node Biopsy in melanoma mortality: timing of dissection Cristina Fortes, Simona Mastroeni, Alessio Caggiati, Francesca Passarelli, Alba Zappalà, Maria Capuano, Riccardo Bono, Maurizio Nudo, Claudia Marino, Paola Michelozzi P22 Epidemiological survey on related psychopathology in melanoma Valeria De Biasio, Vincenzo C. Battarra IMMUNOTHERAPY BRIDGE KEYNOTE SPEAKER PRESENTATIONS Immunotherapy beyond melanoma K19 Predictor of response to radiation and immunotherapy Silvia Formenti K20 Response and resistance to PD-1 pathway blockade: clues from the tumor microenvironment Maria Libera Ascierto, Tracee L. McMiller, Alan E. Berger, Ludmila Danilova, Robert A. Anders, George J. Netto, Haiying Xu, Theresa S. Pritchard, Jinshui Fan, Chris Cheadle, Leslie Cope, Charles G. Drake, Drew M. Pardoll, Janis M. Taube and Suzanne L. Topalian K21 Combination immunotherapy with autologous stem cell transplantation, protein immunization, and PBMC reinfusion in myeloma patients Sacha Gnjatic, Sarah Nataraj, Naoko Imai, Adeeb Rahman, Achim A. Jungbluth, Linda Pan, Ralph Venhaus, Andrew Park, Frédéric F. Lehmann, Nikoletta Lendvai, Adam D. Cohen, and Hearn J. Cho K22 Anti-cancer immunity despite T cell “exhaustion” Speiser Daniel Immunotherapy in oncology (I-O): data from clinical trial K23 The Checkpoint Inhibitors for the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) Vera Hirs

Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016

reserved1229noObjective: This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods: Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy was defined as a prescription of drugs from 5 or more classes. Results: Of 4,133 participants, 969 (23.4%) had delirium. The general prevalence of polypharmacy was higher in patients with delirium (67.6% vs 63.0%, P =.009) but varied according to clinical settings. After adjustment for confounders, polypharmacy was associated with delirium only in patients admitted to surgical units (OR = 2.9; 95% CI, 1.4-6.1). Insulin, antibiotics, antiepileptics, antipsychotics, and atypical antidepressants were associated with delirium, whereas statins and angiotensin receptor blockers exhibited an inverse association. A stronger association was seen between typical and atypical antipsychotics and delirium in subjects free from dementia compared to individuals with dementia (typical: OR = 4.31; 95% CI, 2.94-6.31 without dementia vs OR = 1.64; 95% CI, 1.19-2.26 with dementia; atypical: OR = 5.32; 95% CI, 3.44-8.22 without dementia vs OR = 1.74; 95% CI, 1.26-2.40 with dementia). The absence of antipsychotics among the prescribed drugs was inversely associated with delirium in the whole sample and in both of the hospital settings, but only in patients without dementia. Conclusions: Polypharmacy is significantly associated with delirium only in surgical units, raising the issue of the relevance of medication review in different clinical settings. Specific drug classes are associated with delirium depending on the clinical setting and dementia diagnosis, suggesting the need to further explore this relationship.mixedAloisi Gaetano, Marengoni Alessandra, Morandi Alessandro, Zucchelli, Alberto, Cherubini Antonio, Mossello Enrico, Bo Mario, Di Santo Simona, Mazzone Andrea, Trabucchi Marco, Cappa Stefano, Fimognari Filippo, Antonelli Incalzi Raffaele, Gareri Pietro, Perticone Francesco, Campanini Mauro, Montorsi Marco, Latronico Nicola, Zambon Antonella, Bellelli Giuseppe, Rispoli Vincenzo, Malara Alba, Spadea Fausto, Di Cello Serena, Ceravolo Francesco, Fabiano Francesco, Chiaradia Giuseppe, Gabriele Amedeo, Lenino Peluso, Andrea Taristano, Settembrini Vincenzo, Capomolla Domenico, Citrino Antonella, Scriva Antonietta, Bruno Irene, Secchi Roberto, De Martino Eugenio, Muccinelli Roberto, Lupi Gerardo, Paonessa Patrizio, Fabbri Andrea, Passuti Maria Teresa, Castellari Sofia, Po Andrea, Gaggioli Guido, Varesi Massimo, Moneti Paolo, Capurso Sebastiano, Latini Vincenzo, Ghidotti Stefano, Riccardelli Francesco, Macchi Maurizio, Rigo Rosaria, Claudio Pascale, Bosio Angelo, Cerrato Flavio, Bardelli Benedetta, Boffelli Stefano, Cassinadri Angela, Franzoni Simone, Spazzini Elena, Andretto Daniela, Tonini Gabriele, Andreani Laura, Coralli Mirco, Balotta Antonio, Cancelliere Roberto, Ballardini Giorgio, Simoncelli Margherita, Mancini Annarita, Strazzacapa Mara, Fabio Stefano, De Filippi Francesco, Giudice Chiara, Dentizzi Cosimo, Azzini Margherita, Cazzadori Marco, Mastroeni Valeria, Bertassello Paolo, Santana Helena, Benati Claudia, Nesta Elisa, Tobaldini Chiara, Guerini Fabio, Tambara Elena, Mombelloni Paolo, Fontanini Fulvio, Lassa Gabriella, Lassa, Pizzorni Crosio, Oliverio Martina, del Grosso, Luciano Luca, Giavedoni Cristina, Bidoli Giuliano, Mazzei Bruno, Corsonello Andrea, Fusco Sergio, Vena Silvio, De Vuono Tommaso, Maiuri Giorgio, Fimognari Filippo Luca, Arone Andrea, Sgro Giovanni, Nicolazzo Rossella, Castegnaro Eugenio, De Rosa Salvatore, Sechi Bazzano Rossella, Benvenuti Enrico, Del Lungo Ilaria, Giardini Sante, Giulietti Chiara, Di Bari Mauro, Barghini Eleonora, Paoli Martina, Fiordelli Irene, Barucci Riccardo, Sgrilli Federica, Del Lungo Ilaria, Bertoletti Erik, D'Amico Ferdinando, Caronzolo Francesco, Grippa Alessandro, Lombardo Giuseppina, Pipicella Tiziana, Saitta Antonino, Corica Francesco, Cucinotta Valeria, Giaritta Prestipino, Larosa Daniela, Cucinotta Domenico, Basile Giorgio, March Albert, Nitti Maria Teresa, Felici Alessandro, Pavan Silvia, Piazzani Fabrizio, Lunelli Alessandra, Dimori Sergio, Margotta Alessandro, Soglia Tiziano, Postacchini Demetrio, Brunelli Roberto, Santini Silvia, Francavilla Monia, Macchiati Ilenia, Sorvillo Francesca, Giuli Cinzia, Mecocci Patrizia, Longo Annalisa, Perticone Francesco, Addesi Desiree, Rosa Paola Cerra, Bencardino Giuseppe, Falbo Tania, Grillo Nadia, Filice Marco, Mirella Filippo, Fanto Fausto, Isaia Gianluca, Pezzilli Stella, Bergamo Daniele, Furno Elisabetta, Rrodhe Sokol, Lucarini Simonetta, Dijk Babette, Dall'Acqua Francesca, Cappelletto Francesco, Calvani Donatella, Becheri Dimitri, Mottino Giuseppe, Mitidieri Costanza, Antonio Vito, Bartalucci Francesca, Magherini Lorenza, Malin Novella, Boni Franca, Gambardella Paoli Martina Lucia, Valente Carlo, Bracali Ilaria, Bracali, Foschini Alice, Bo Mario, Porrino Paola, Ceci Giacomo, Bottignole Giuliana, Tibaldi Michela, Coppo Eleonora, Ettore Evaristo, Camellini Cinzia, Servello Adriana, Grassi Alessandro, Rozzini Renzo, Tironi Sara, Grassi Maria Grazia, Troisi Elio, Caltagirone Carlo, Di Santo Simona, Franchini Flaminia, Ratto Federica, Pavoni Beatrice, Toniolo Sofia, Gabutto Anna, Quazzo Loredana, Rosatello Annalisa, Suraci Domenico, Tagliabue Benedetta, Perrone Chiara, Ferrara Lucia, Castagna Alberto, Tremolada Maria Luisa, Castoldi Giuseppe, Barbero Stefano, Oltramonti Davide, Piano Simonetta, Serviddio Gaetano, Lo Buglio Aurelio, Gurrera Tiziana, Merlo Valeria, Rovai Carla, Cotroneo Antonino Maria, Carlucci Rosaria, Abbaldo Anna, Monzani Fabio, Qasem Ahmad Amedeo, Bini Giacomo, Tafuto Silvia, Galli Giovanni, Bruni Amalia Cecilia, Mancuso Giovanna, Mancuso Gerardo, Calipari Daniela. De Luca Giuseppe Massimiliano, Bernardini Bruno, Corsini Carla, Ciccarelli Michele, Dal Farra Sara, Dal Farra, Cagnin Annachiara, Fragiacomo Federica, Pompanin Sara, Amodio Piero, Cagnin Marco, Zurlo Amedeo, Guerra Gianluca, Pala Marco, Menozzi Luca, Delli Gatti Chiara, Magon Stefania, Manfredini Roberto, De Giorgi Alfredo, Fabbian Fabio, Tiseo Ruana, Misurati Elisa, Boari Benedetta, Molino, Christian, Gallerani Massimo, Di Francesco Vincenzo, Faccioli Silvia, Pellizzari Luca, Fontana Giorgia, Barbagallo Giuseppe, Lunardelli Maria Lia, Martini Emilio, Ferrari Eleonora, Macchiarulo Maria, Corneli Maria, Bacci Monica, Battaglia Giuseppe, Anastasio Luigi, Lo Storto Mario Sostene, Seresin Chiara, Simonato Matteo, Loreggian Michele, Cestonaro Fausta, Durando Mario, Latella Raffaele, Mazzoleni Marta, Russo Giuseppe, Ponte Martino, Valchera Alessandro, Salustri Giuseppe, Petritola Donatella, Costa Alfredo, Sinforiani Elena, Cotta Matteo Ramusino, Piano Simonetta, Pizio Renato Nicola, Cester Alberto, Formilan Marino, Bonometto Pietro, Carbone Pasqualina, Cazzaniga Ilaria, Appollonio Ildebrando, Cereda Diletta, Stabile Andrea, Xhani Rubjona, Acampora Roberto, Tremolizzo Lucio, Pieruzzi Federico, Ciaccio Antonio, Pontecorvi Valerio, Burti Cesare, Mokini Zhirajr, Vitale Giovanni, Amigoni Maria, Sparacino Mariaelena, Bottacchi Edo, Bucciantini Elisabetta, Di Giovanni Marco, Franchi Fabrizio, Lucchetti Lucio, Mariani Claudio, Grande Giulia, Rapazzini Piero, Mauri Marco, Romanelli Giuseppe, Marengoni Alessandra, Nicosia Franco, Margola Alessio, Bonardelli Stefano, Latronico Nicola, Porcella Laura, Portolani Nazario, Concoreggi Carlo, Grassini Chiara, Salvi Andrea, Bianchetti Luca, Spagnoli Francesca, Apuzzo Roberto, Fontanella, Ceraso Anna, Castelli Francesco, Fugazza Luciano, Guerrini Chiara, De Paduanis Giovanna, Iallonardo Lucia, Palumbo Pasquale, Zuliani Giovanni, Ortolani Beatrice, Capatti Eleonora, Soavi Cecilia, Bianchi Lara, Francesconi Daniela, Miselli, Agata, Brombo Gloria, Romagnoli Tommaso, Pazzaglini Chiara, Miselli Maria Agata, Dall'Agata Marco, Suardi Teresa, Mazzone Andrea, Zaccarini Cinzia, Riva Manuela, Mirra Gianluca, Muti Ettore, Bottura Renato, Moretti Gianpaolo, Secreto Piero, Bisio Erika, Cecchettani Marco, Naldi Tamara, Pallavicino Alessandra, Pugliese Michela, Iozzo Rosaria Cosima, Grassi Guido, Bombelli Michele, DellOro Raffaella, Quarti Trevano Fosca, Giussani Carlo Giorgio, Paterno Giovanni, Contro Ernesto, Mannironi Antonio, Giorli Elisa, Oberti Sara, Fierro Brigida, Piccoli Tommaso, Giacalone Fabio, Mandas Antonella, Serchisu Luca, Costaggiu Diego, Pinna Elisa, Orru Francesca, Mannai Martina, Cordioli Zeno, Pelizzari Luca, Turcato Emanuela, Arduini Pietro, Cacace Carlo, Chiloiro Roberta, Cimino Rosella, Ruberto Carmen, Ruotolo Giovanni, Gareri Pietro, Greco Laura, Castagna Alberto, Dal Santo Pierluigi, Andriolli Antonino, Burattin Giuseppe, Rossi Laura, Andreolli Antonino, Cervati Giovanna, Catalano Giuseppe, Tezza Fabiana, Pizzardini Maddalena, Stievano Laura, Crippa Patrizia, Aloisio Paola, Di Monda Tiziana, Malighetti Alessandro, Galbassini Gloria, Ivaldi Claudio, Russo Anna Maria, Bennati Ettore, Pino Elisabetta, Zavarise Gianmaria, Pesci Alberto, Suigo Giulia, Faverio Paola, Gori Andrea, Perego Sabrina Perego, Zanasi Massimo, Moniello Giovanni, Rostagno Carlo, Cartei Alessandro, Polidori Gianluca, Ungar Andrea, Melis Maria Ramona, Martellini Eleonora, Mossello Enrico, Torrini Monica, Giordano Antonella, Leone Giovanna, Migliorini Marta, Caramelli Francesca, Battiston Bruno, Berardino Maurizio, Cavallo Simona, Masse Alessandro, Santoro Anna, Lombardi Bruna, D'Ippolito Pierpaolo, Furini Angela, Villani Daniele, Raimondi Clara, Guarneri Massimo, Paolucci Stefano, Bassi Andrea, Coiro Paola, De Angelis Domenico, Morone Giovanni, Venturiero Vincenzo, Palleschi Lorenzo, Raganato Paolo, Di Niro Giuseppina, Casini Anna Rosa, Bove Loredana, Imoscopi Alessandra, Isaia Giancarlo, Tibaldi Vittoria, Bottignole Giuliana, Calvi Elisa, Clementi Carlotta, Zanocchi Mauro, Agosta Luca, Criasia Antonio, Spertino Elena, Nortarelli Antonella, Provenzano Giuseppe, Principato Pietro, Rizzo Anita, Cellura Eleonora, Mari Daniela, Romano Federica Ylenia, Rosini Francesca, Mansi Marta, Rossi Silvia, Riccardelli Alex, Inzaghi Lorenzo, Bonini Giulia, Rossi Paolo, Potena Alfredo, Lichii Mihaela, Candiani Tiziana, Grimaldi William, Bertani Emiliano, Porta Alessandra, Calogero Pietro, Pinto Daniela, Bernardi Roberto, Nicolino Francesco, Galetti Caterina, Gianstefani Alice, Corvalli Giulia, Mulazzani Lorenzo, Odetti Patrizio, Monacelli Fiammetta, Prefumo Matteo, Monacelli Fiammetta, Canepa Marta, Minaglia Cecilia, Paolisso Giuseppe, Rizzo Maria Rosaria, Prestano Raffaele, Dalise Anna Maria, Barra Davide, Dal Bosco Livio, Asprinio Vincenzo, Dallape Luciana, Maina Paola, Perina Elisa, Bartoli Rossi Isaura, Pluderi Alice, Maina Antonella, Pecoraro Elisabetta, Sciarra Michela, Prudente Angela, Mete Francesca, Ventura Manuel, Cesari Luisella, Pernigotti Luigi Maria, Santangelo Tina, Benini Lucia, Levato Francesco, Mhiuta Victor, Alius Florin, Davidoaia Diana, Giardini Vittorio, Garancini Mattia, Bellamoli Claudio, Terranova Luciano, Bozzini Claudia, Tosoni Paolo, Provoli Emma, Cascone Luisa, Dioli Andrea, Ferrarin Gianfranco, Gabutto Anna, Bucci Adelmo, Bua Guido, Fenu Sara, Bianchi Giovanna, Casella Silvia, Romano Valentina, Poli Maurizio, Mascherona Ilenia, Belotti Gloria, Cavaliere Sabina, Cuni Estella, Merciuc Nina, Oberti Rosella, Veneziani Silvia, Capoferri Emanuela, De Bernardi Elisabetta, Colombo Katia, Bravi Marco, Negrinotti Nicoletta, D'Arcangelo Paolo, Montenegro Nicola, Galli Giovanni, Montanari Roberto, Lamanna Pierpaolo, Gasperini Beatrice, Montesi Isabella, Diotallevi Stefania, Altobelli Gaia, Cacinaro Filippo, Palama Chiara, Di Emidio Chiara, Scarpini Elio, Arighi Andrea, Scrimieri Antonia, Fumagalli Giorgio, Basilico Paola, Migone De Amicis Margherita, Mancarella Marta, Maira Diletta, D'Amico Ferdinando, Granata Antonino, Ranalli Claudia, Cammilli Alessandra, Cavallini Maria Chiara, Tricca Manola, Natella Daniela, Gabbani Luciano, Tesi Francesca, Martella Letizia, Gurrera Tiziana, Imbrici Rosalba, Pacchioni Maurizio, Gianbattista Guerrini, Scotuzzi Anna Maria, Sozzi Ferdinando, Valenti Luigi, Chiarello Antonino, Monella Monia, Pilotto Alberto, Prete Camilla, Senesi Barbara, Meta Anna Cristina, Pendenza Enrico, Monzani Fabio, Pasqualetti Giuseppe, Polini Antonio, Tognini Sara, Ballino Elena, Cherubini Antonio, Dell'Aquila Giuseppina, Gasparrini Pina Maria, Marotti Elisabetta, Migale Monica, Falsetti Lorenzo, Salvi Aldo, Toigo Gabriele, Ceschia Giuliano, Rosso Alessia, Tongiorgi Chiara, Scarpa Cristina, De Dominicis Luigino, Pucci Eugenio, Renzi Sara, Cartechini Elisabetta, Tomassini Pia Francesca, Del Gobbo Maurizio, Ugenti Francesca, Romeo Pasquale, Nardelli Anna, Lauretani Fulvio, Visioli Sandra, Montanari Ilaria, Ermini Francesca, Giordano Antonio, Pigato Giorgio, Simeone Emilio, Colameco Franco, Cecamore Antonella, Scurti Rosa, Lupinetti Maria Cristina, Barbujani Mario, Perazzi Beatrice, Giampieri Marina, Amoruso Raffaele, Piccinini Maristella, Ferrari Camilla, Gambetti Claudio, Sfrappini Mario, Semeraro Letizia, Striuli Rinaldo, Mariani Claudia, Pelliccioni Giuseppe, Marinelli Donatella, Fabi Katia, Rossi Tommaso, Pesallaccia Martina, Sabbatini Debora, Gobbi Beatrice, Cerqua Raffaella, Tagliani Giancarla, Schlauser Elena, Caser Luciano, Caramello Elisa, Sandigliano Franca, Rosso Giorgio, Bendini Chiara, Davoli Maria, Casella Monica, Prampolini Raffaella, Scevola Moreno, Vitale Enrico, Brugiolo Roberto, Brugiolo, Fagherazzi Carlo, Fusco Sergio, Scarpa Alberto, Zara Daniela, Bertozzo Giulia, Granziera Serena, Barazzuol Michele, Maugeri Domenico, Sorace Rosaria, Anzaldi Massimiliano, De Gesu Roberto, Morrone Giuseppe, Davolio Federica, Fabbo Andrea, Palmieri Marina, Forti Paola, Pirazzoli Luca, Fabbri Elisa, Terenzi Laura, Bergolari Federica, Wenter Christian, Ruffini Ingrid, Insam Miriam, Abraham Elisabeth, Kirchlechner Christine, Lasco Antonino, Basile Giorgio, Arena Maria Grazia, Parise Pasquale, Boccali Andrea, Amici Serena, Gambacorta Maurizia, Ferrari Alberto, Lasagni Anna, Lovati Roberto, Giovinazzo Francesca, Kimak Elzbieta, Zappa Paolo, Medici Francesco, Lo Castro Marika, Mauro Flavia, De Luca Alessandro, Sancesario Giuseppe, Martorana Alessandro, Scaricamazza Beatrice, Toniolo Sofia, Di Lorenzo Francesco, Liguori Claudio, Lasco Antonino, Basile Giorgio, Vita Natale, Giomi Mirna, Dimori Sergio, Forte Floriana, Padovani Alessandro, Rozzini Luca, Ceraso Anna, Caratozzolo Salvatore, Padovani Alessandro, Cottino Maria, Vitali Silvia, Marelli Eleonora, Tripi Gabriele, Miceli Salvatore, Urso Giovanni, Grioni Giuseppe, Vezzadini Giuliana, Misaggi Giulia, Forlani Chiara, Avanzi Stefano, Saulle Serena, Casarini Claudia, Viggiano Marilena, Alberto Luisa, Ghianda Diego, Giordano Alessandro, Iemolo Francesco, Giordano, Antonello, Sanzaro Enzo, D'Asta Gabriele, Proietto Maria, Carnemolla Anna, Razza Grazia, Spadaro Daniela, Bertolotti Marco, Mussi Chiara, Neviani Francesca, Chiesa Roberto, Guerzoni Valentina, Morselli Linda, Venturelli Francesca, Tarozzi Adriano, Balestri Francesca, Torrini Monica, Mannarino Giulio, Tesi Francesca, Bigolari Michela, Natale Alessia, Grassi Simona, Bottaro Cinzia, Stefanelli Sara, Bovone Ugo, Tortorolo Umberto, Quadri Roberto, Leone Giuseppe, Ponzetto Maria, Frasson Paola, Annoni Giorgio, Bellelli Giuseppe, Bruni Adriana, Confalonieri Roberto, Corsi Maurizio, Moretti Daniela, Teruzzi Fabiola, Umidi Simona, Mazzola Paolo, Perego Sabrina, Persico Ilaria, Olivieri Giulia, Bonfanti Alessandra, Hajnalka Szabo, Galeazzi Marianna, Massariello Francesca, Anzuini Alessandra, Caffarra Paolo, Barocco Federica, Spallazzi Marco, Ceda Gian Paolo, Morganti Simonetta, Artoni Andrea, Chioatto Paolo, Bortolamei Sandra, Soattin Lucia, Ruotolo Giovanni, Beneamino Borelli, Gareri Pietro, Barilaro Giuseppe, Ruberto Carmen, Castagna Alberto, Bertazzoli Marco, Rota Elisabetta, Adobati Annamaria, Scarpa Alberto, Granziera Serena, Zuccher Paola, Dal Fabbro Angela, Zara Daniela, Lo Nigro Ambra, Franchetti Lorena, Toniolo Marika, Marcuzzo Cinzia, Piano Simonetta, Rollone Marco, Guerriero Fabio, Sgarlata Carmelo, Masse Alessandro, Berardino Maurizio, Cavallo Simona, Anna Santoro, Zatti Giovanni, Piatti Massimiliano, Graci Jole, Benati Giuseppe, Boschi Federica, Biondi Mario, Fiumi Nicoletta, Erika Tamburini, Locatelli Sergio Mario, Mauri Sabrina, Beretta Mauro, Margheritis Laura, Desideri Giovanbattista, Liberatore Ester, Carucci Anna Cecilia, Bonino Paolo, Caput Margherita, Antonietti Maria Paola, Polistena Giuseppe, De la Pierre Franz, Mari Marcello, Massignani Paola, Tombesi Fabio, Selvaggio Fabio, Verbo Brunella, Bodoni Paolo, Marchionni Niccolo, Mossello Enrico, Cavallini Maria Chiara, Sabatini Tony, Mussio Eleonora, Magni Eugenio, Bianchetti Angelo, Crucitti Andrea, Titoldini Giulia, Cossu Beatrice, Fascendini Sara, Licini Cristina, Tomasoni Angela, Calderazzo Massimo, Tropiano Daniela, Lagana Valentina, Ferrari Alberto, Prampolini Raffaella, Melotti Rita Maria, Lilli Albina, Buda Simona, Adversi Marco, Noro Gabriele, Turco Renato, Ubezio M. Chiara, Mantovani Anna Roberta, Viola Maria Cristina, Serrati Carlo, Pretta Stefano, Infante Maria, Gentile Simona, Morandi Alessandro, D'Ambrosio Viviana, Mazzanti Paolo, Brambilla Cristina, Sportelli Silvia, Platto Caterina, Faraci Bianca, Quattrocchi Daniela, Pisu Cristina, Sicuro Francesca, Oliverio Martina, Del Grosso Luciano Luca, Zagnoni Piergiuseppe, Ghiglia Stefania, Mosca Massimiliano, Corazzin Ileana, Deola Mariangela, Biagini Carlo Adriano, Bencini Francesca, Cantini Claudia, Tonon Elisabetta, Pierinelli Silvia, Onofrj Marco, Thomas, Astrid, Borbone Filomena, Bonanni Laura, Cacchio Gabriella, Comi Giancarlo, Magnani Giuseppe, Santangelo Roberto, Mazzeo Salvatore, Magnani Giuseppe, Caso Francesca, Cecchetti Giordano, Sant’Angelo Roberto, Barbieri Cristina, Giroldi Liviana, Davolio Federica, Bandini Fabio, Masina Marco, Malservisi Simona, Cicognani Annalena, Ricca Laura, Piccininni Maristella, Ferrari Camilla, Gambetti Claudio, Tassinari Tiziana, Brogi Davide, Sugo Annalisa, Filippi Alessandra, Manfredi Sonia, Vanni Valerio, Usai carlo Andrea, Colombo Enrico, Renna Vera Francesca, Sauchella Assunta, Zavarise Gianmaria, Prete Mauro, Bisagni Pietro, Masini Roberto, Carrabetta Salvatore, Barone Antonella, Razzano Monica, Imperoli Giuseppe, Bini Angela, Serra Francesco, D’Agostino Valeria, Gianolla Federico, Pietrangeli Lucia, Velardi Antonella, Di Cello Elisabetta, Rosati Cristina, Casali Nadia, Casali, Sessa Maria, Abruzzi Luciano, Costanzi Chiara, Bini Paolo, Pignata Michele, Buonaugurio Enrico, Vollery Maria, Carrieri Giovanni, Cioni Giorgio, Toschi Andrea, Metra Marco, Ceraso Anna, Ranieri Piera, Zucchelli Alberto, Ceccon Anna, Magrin Laura, Marin Sara, Barbara Sofia, Masina Marco, Ghedini Laura, Moroni Matteo, Paragona Marco, Pallotti Maria Caterina, Rota Carla, Gottardi Federica, Tomasoni Clara, Cappuccio Melania, Bonini Giampaolo, Guerini Stefano, Guerini Valeria, Merlaj Lucia, Liberatore Ester, Carucci Anna Cecilia, Tovaglieri Maurizio, Filippi Alessandra, Antonio Grillo, Francesca Arenare, Mineo Tonino, Kanah David, Vianello Giorgio, Vianello Piero, Balducci Ubaldo, Sidoti Vincenzo, Montanari Stefano, Formilan Marino, Murelli Flavio Teodolindo Busonera, Albanese Paolo, Maselli Monica, Bolzetta Francesco, Fabris Roberto, Bonino Paolo, Durante-Mangoni Emanuele, Testoni Michela, Di Stefano Fabio, Seccia Loredana, Sonzini Valeria, Fabiano Maria, Di Giorgio Annabella, De Cosmo Salvatore, Greco Antonio, D’Onofrio Grazia, Sancarlo Daniele, Resta Gianluca, Girardello Renzo, Girardello, Minervini Sergio, Boni Morena, Vitali Mariagrazia, Pizzoni Marina, De Colle Paolo, Scarpa Cristina, Frattola Alessandra, Orlandini Francesco, La Regina Micaela, Addesi Desiree, Mirella Filippo, Filice Marco, Bo Mario, Porrino Paola, Bottignole Giuliana, Tibaldi Michela, Coppo Eleonora, Padulo Filomena, Margheriti Cristina, Rolano Dario, Moscatelli Giancarla, Radaelli Guido, Montini Elena, Prete Cosimo, Novello Marileda, Bramuzzo Igor, Bertin Nicole, Rinaldo Elena, Paolillo Ciro, Riccardi Angela, Benedetti Claudia, Rizzi Barbara, Montagna Francesca, Vitali Silvia, Cutaia Chiara, Baca Oliver, Colombo Mauro, Marelli Eleonora, Procino Giuseppe, Tarara Rosaria, Cottino Maria, Dell’Acqua Davide, Cislaghi Stefania, Cairati Marco, Porta Massimo, Scaglione Luca, De Feo Martina, Vertolli Paola, Salvati Lia, Cinotti Sandro, De Santis Valentina, Biferi Erminia, Cheli Paola, Rebizzo Romina, Salvatore Minisola, Luciano Colangelo, Abete Pasquale, Liguori Ilaria, Curcio Francesca, Spassini Guglielmo, Engheben Marco, Rotunno Sara, Rotunno, Arosio Paola, Angelini Claudio, Reggiani Francesco, Cappelli Alessandro, Marcheselli Simona, Fratticci Lara, Ranzani Paola, Cesarini Simonetta, Cerini Antonella, Gallucci Fernando, Ceschia Giuliano, Serra Emanuela, Sola Mariolina, Delitala Alessandro, Pes Chiara, Lobianco Giulia, Giani Alessandro, Famularo Simone, Sandini Marta, Pinotti Enrico, Gianotti Luca, Battuello Antonella, Pintore Giulia, Giardini Sante, Rossi Andrea, Rubele Sofia, Sant Selena, Vignati Marco, Clerici Danila, Rosa Fabio, Bandirali Maria Pia, Cattaneo Nicoletta, Boffi Laura, Tosoni Paolo, Terranova Luciano, Avalli Leonello, Scanziani Margherita, De Notaris Stefania, Del Santo Pierluigi, Del Santo, Rossi Laura, Tezza Fabiana, Andreolli An