Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

The regional conception in the sphere of industrial and domestic waste handling

The article considers problems related to education, collection, neutralization and treatment of industrial and domestic wastes on the territory of the Nizhny Novgorod region. The necessity to modernize the whole sphere of waste treatment is shown

Magnetic Properties of Novel Layered Disulfides CuCr0.99Ln0.01S2 (Ln = La…Lu)

The comprehensive study of the lanthanide-doped solid solutions CuCr0.99Ln0.01S2 (Ln = La…Lu) magnetic properties was carried out using static magnetochemistry and differential scanning calorimetry techniques. It was shown that magnetic properties of CuCr0.99Ln0.01S2 are significantly affected by the magnetic properties of the lanthanide ion. The magnetic susceptibility and the effective magnetic moment were found to deviate from the Curie-Weiss law in the temperature 90 K below and 50 K above the order-disorder transition at 695 K. The observed behavior of the temperature dependence of the effective magnetic moment in the order-disorder transition temperature region was described as a result of copper atoms redistribution over different types of the crystallographic sites

Catalysts Derived from Nickel-Containing Layered Double Hydroxides for Aqueous-Phase Furfural Hydrogenation

Changes in the structural and textural properties of NiAl-layered double hydroxides (LDHs) (with 2–4 molar ratios of metals) and state of nickel that occur in different steps of the synthesis of nickel catalysts were studied using XRD, thermal analysis, TPR, low-temperature nitrogen adsorption, XANES, EXAFS, and electron microscopy methods. Relations between nickel content, catalyst reduction conditions, state of nickel, and its catalytic properties were revealed. It was shown that the use of NiAl LDH as the catalyst precursor even at a high content of active metal allows for the obtaining of the dispersed particles of supported nickel that are active in the aqueous-phase hydrogenation of furfural. The catalyst activity and conversion of furfural were found to increase with elevation of the catalyst reduction temperature and the corresponding growth of the fraction of reduced nickel. However, a lower reduction temperature (500 °C) makes it possible to form smaller nickel particles with the size of 4–6 nm, and a high Ni content (Ni:Al = 4) can be used to obtain the active Ni@NiAlOx catalyst. Under mild reaction conditions (90 °C, 2.0 MPa), the furfural conversion reached 93%, and furfuryl alcohol was formed with the selectivity of 70%. Under more severe reaction conditions (150 °C, 3.0 MPa), complete conversion of furfural was achieved, and cyclopentanol and tetrahydrofurfuryl alcohol were the main hydrogenation products

Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives

New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L1) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L2) with compositions Cu(L1)2Br2, Cu(L1)(C2N3)2, Cu(L2)Cl2, and Cu(L2)Br2 were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L1 were determined. The structures of the coordination core of complexes Cu(L2)Cl2 and Cu(L2)Br2 were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L1)2Br2 to alternating-exchange antiferromagnetic chains in Cu(L1)(C2N3)2, where double dicyanamide bridges provide an unusually strong exchange interaction (J1/kB ≈ −23.5 K; J2/kB ≈ −20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L2 was estimated on the human cell lines of breast adenocarcinoma (MCF-7) and hepatocellular carcinoma (HepG2)

Pd Active Sites on Covalent Triazine Frameworks for Catalytic Hydrogen Production from Formic Acid

Covalent triazine frameworks (CTF) have been recently applied as supports for metal catalysts for different reactions. Varying the nature of the CTF support could improve catalytic properties due to a change in the nature of metal active sites presented in the form of single atoms and dispersed nanoparticles. To understand these changes, for the first time, 1 wt % Pd catalysts supported on hatnCTF and acacCTF prepared from hexaazatrinaphthylene-tricarbonitrile and malonyldibenzonitrile, respectively, were tested in formic acid decomposition in the gas phase. The results were compared with those obtained for a Pd/g-C3N4 catalyst. The catalysts were characterized by high-angle annular dark-field/scanning transmission electron microscopy, X-ray absorption near edge structure/extended X-ray absorption fine structure and X-ray photoelectron spectroscopy. The activity of the Pd/hatnCTF catalyst was significantly higher than those for Pd/acacCTF and Pd/g-C3N4, providing the reaction at a lower temperature by ∼60 K. The high performance of this catalyst was attributed to single-atom Pd2+–C1N3 sites, which are the main active Pd species in this sample. The Pd/acacCTF sample contained single-atom Pd2+–O4 sites and metallic Pd nanoparticles, while the Pd/g-C3N4 sample contained mainly metallic Pd nanoparticles. The selectivity toward H2 was high (>98%) for all catalysts even at 573 K. The obtained results could be useful for the development of different applications of CTF materials.This work was supported by the Russian Science Foundation (grant 22-23-00608). H.S.J. thanks the Ghent University and UGent Concerted Research Action funding via GOA010-17 for the synthesis of the CTF supports

Single-Atom Pd Catalysts Supported on Covalent Triazine Frameworks for Hydrogen Production from Formic Acid

According to our knowledge, single-atom Pd catalysts supported on covalent triazine frameworks (CTF) have not been studied in the production of hydrogen from formic acid. Therefore, we synthesized 1 wt % Pd single-atom catalysts based on CTF-1, pyCTF, and bipyCTF supports and tested them in the gas-phase decomposition of formic acid. The results were compared with those obtained for a Pd catalyst supported on mesoporous graphitic-type carbon (Pd/C) with nanoparticles (∼2.3 nm). The catalysts were characterized by high-angle annular dark-field/scanning transmission electron microscopy (HAADF/STEM), extended X-ray absorption fine structure/X-ray absorption near-edge structure (EXAFS/XANES), and X-ray photoelectron spectroscopy (XPS) methods. The following order of catalytic activity was obtained: Pd/CTF-1 > Pd/C > Pd/pyCTF ≥ Pd/bipyCTF. The best performance of the Pd/CTF-1 catalyst was associated with Pd2+–C2N2 sites. Pd2+–N4 sites formed on pyCTF and bipyCTF supports showed lower catalytic activity. The selectivity trend at temperatures above 500 K was as follows: Pd/bipyCTF > Pd/pyCTF > Pd/CTF-1 > Pd/C. For the Pd/bipyCTF catalyst, the selectivity reached 99.8%, which is very high for this temperature range. These results may be important for the development of CTF-based catalysts for hydrogen production reactions.This work was supported by the Russian Science Foundation (Grant 22-23-00608). H.S.J. is grateful for the Ghent University and UGent Concerted Research Action funding via GOA010-17 for the synthesis and characterization of the CTF-based supports

Pd Active Sites on Covalent Triazine Frameworks for Catalytic Hydrogen Production from Formic Acid

Covalent triazine frameworks (CTF) have been recently applied as supports for metal catalysts for different reactions. Varying the nature of the CTF support could improve catalytic properties due to a change in the nature of metal active sites presented in the form of single atoms and dispersed nanoparticles. To understand these changes, for the first time, 1 wt % Pd catalysts supported on hatnCTF and acacCTF prepared from hexaazatrinaphthylene-tricarbonitrile and malonyldibenzonitrile, respectively, were tested in formic acid decomposition in the gas phase. The results were compared with those obtained for a Pd/g-C3N4 catalyst. The catalysts were characterized by high-angle annular dark-field/scanning transmission electron microscopy, X-ray absorption near edge structure/extended X-ray absorption fine structure and X-ray photoelectron spectroscopy. The activity of the Pd/hatnCTF catalyst was significantly higher than those for Pd/acacCTF and Pd/g-C3N4, providing the reaction at a lower temperature by ∼60 K. The high performance of this catalyst was attributed to single-atom Pd2+–C1N3 sites, which are the main active Pd species in this sample. The Pd/acacCTF sample contained single-atom Pd2+–O4 sites and metallic Pd nanoparticles, while the Pd/g-C3N4 sample contained mainly metallic Pd nanoparticles. The selectivity toward H2 was high (>98%) for all catalysts even at 573 K. The obtained results could be useful for the development of different applications of CTF materials