Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Legal aspects of legislative regulation of information security and protection of information in data centers

In modern conditions, information is one of the most important business resources that need protection. Therefore, today, the issue of developing the information security management system and its implementation in organizations is conceptual. The paper reveals the problems of the information security in two main aspects at the level of legislative regulation and the information security in data centers. A number of features characterizing information as an object of legal relations have been determined. The international standards regulating the issues of information security, in particular the safety of data centers, are singled out. The paper touches upon the main requirements that modern data centers should meet. The authors identified the main types of risks when using an external data center, and suggested ways to minimize them

Legal aspects of legislative regulation of information security and protection of information in data centers

In modern conditions, information is one of the most important business resources that need protection. Therefore, today, the issue of developing the information security management system and its implementation in organizations is conceptual. The paper reveals the problems of the information security in two main aspects at the level of legislative regulation and the information security in data centers. A number of features characterizing information as an object of legal relations have been determined. The international standards regulating the issues of information security, in particular the safety of data centers, are singled out. The paper touches upon the main requirements that modern data centers should meet. The authors identified the main types of risks when using an external data center, and suggested ways to minimize them

Children living with HIV in Europe: do migrants have worse treatment outcomes?

International audienceTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe