Monitoring of composition of LNAPL: essential tool for the estimation of free LNAPL specific volumes

Light Non-Aqueous Phase Liquid, Pancake Model, Vertical Equilibrium Mode

The emergent city. Interactive relational systems between public administration and citizen to foster sustainable processes of urban development

The widespread of Information and Communication Technologies and the consequently redefinition of roles in the usage and management of the city brought along new systems of relationships and interactions that produce an auto-organisation of territories or communities, showed also through temporary transformation of the environment. In effect, cities are continuously redefined by emergent properties that may, both be originated and then impact on social, political, cultural, and economical people practices. On the other hand, through the arrangement of its patterns the city shapes the social and connective relations occurring among people. So, the city can be regarded as a complex system, that in the last years has been expanded by the widespread of communication devices and sensors connected to the Internet. In this context, the design of new patterns of interactions that focuses on the new relationship opportunities, in part offered by the Information and Communication Technologies, but not limited to them, may significantly affect sustainable processes of urban development. This paper focuses on the civic aspect of the so-called smart cities, and, in details, on the relation between citizens and Public Administration. Some existing interaction patterns are illustrated in order to support the visualisation of the dynamic relationships between citizens and Public Administration, while new possible relations derived by the interaction with the urban space are supposed

Oral contraceptives combined with interferon β in multiple sclerosis

Objective: To test the effect of oral contraceptives (OCs) in combination with interferon b (IFN-b) on disease activity in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: One hundred fifty women with RRMS were randomized in a 1:1:1 ratio to receive IFNb-1a subcutaneously (SC) only (group 1), IFN-b-1a SC plus ethinylstradiol 20 mg and desogestrel 150 mg (group 2), or IFN-b-1a SC plus ethinylestradiol 40 mg and desogestrel 125 mg (group 3). The primary endpoint was the cumulative number of combined unique active (CUA) lesions on brain MRI at week 96. Secondary endpoints included MRI and clinical and safety measures. Results: The estimated number of cumulative CUA lesions at week 96 was 0.98 (95% confidence interval [CI] 0.81–1.14) in group 1, 0.84 (95% CI 0.66–1.02) in group 2, and 0.72 (95% CI 0.53–0.91) in group 3, with a decrease of 14.1% (p 5 0.24) and 26.5% (p 5 0.04) when comparing group 1 with groups 2 and 3, respectively. The number of patients with no gadoliniumenhancing lesions was greater in group 3 than in group 1 (p 5 0.03). No significant differences were detected in other secondary endpoints. IFN-b or OC discontinuations were equally distributed across groups. Conclusions: Our results translate the observations derived from experimental models to patients, supporting the anti-inflammatory effects of OCs with high-dose estrogens, and suggest possible directions for future research

Groundwater flow and geochemical modeling of the Acque Albule thermal basin (Central Italy): a conceptual model for evaluating influences of human exploitation on flowpath and thermal resource availability

Although the Acque Albule Basin has been studied since the middle of the 19th century, a comprehensive geologic conceptual model of the area has not yet been developed. The natural setting has been heavily modified by anthropic activities. Rapid evolution during the last 25 years has caused many interferences, which have led to a drastic increase of the hazards and linked risks, mainly related to water resource overexploitation and subsidence. The implementation of an exhaustive framework has become mandatory for environmental and management purposes. Starting from a critical review of previous studies, hydrogeologic and hydrogeochemical surveys and related numerical modeling have been carried out in order to achieve a quantitative understanding of the active phenomena and processes. Several hydrogeologic issues have been addressed concerning aquifer recharge areas and the different flowpaths of groundwater in respect to their division into a shallow and a deep circuit. Account has been taken of the groundwater chemistry as a function of water—rock interactions and mixing processes with uprising fluids. Different scenarios of groundwater flow in the Acque Albule aquifer have been built, using previously available piezometric measurements and the hydrodynamic parameters determined by in situ tests. These results led to the formulation of an updated hydrogeologic conceptual model to be further implemented, in which past, present and future anthropic instances and the potential of natural resources of the area have been included and taken into account. A sound conceptual model must rely on the design and development of a logical geo-database in which information is stored, updated and processed. This operational framework can result in a useful tool for land management, surveys planning and design, hazard and risk evaluation, identification of best practices and economic development of the area

Performance of concrete reinforced with synthetic fibres obtained from recycling end-of-life sport pitches

Micro-plastics pollution has risen at an alarming pace over the last decades and it is now recognised as a leading environmental emergency. Indeed, only a very small fraction of annual plastic production is successfully reused, while the vast majority is either disposed of (mainly through incineration or landfilling) or dispersed into the environment. In this paper, polyolefins synthetic fibres, obtained from processing disposed artificial turf pitches aimed at paving sport facilities, are studied. Focus is set on assessing their potential for the Fibre Reinforced Concrete (FRC) technology. Mechanical performance is discussed at two fibre volume fractions, namely 3% and 5% vol., alongside environmental impact. The former is assessed in bending and reveals a significant enhancement of the post-crack energy dissipation capability, whose extent is compatible with what is usually obtained by the adoption of virgin fibres. This is especially significant in consideration of the light processing operated on the waste material. Indeed, life cycle assessment is adopted to evaluate the environmental impact of fibre reuse against fibre manufacturing from either virgin materials or plastic waste. It clearly appears that fibre reuse brings a double environmental benefit: on the one side, it decreases the need for new plastics and, on the other, it reduces plastic waste, whose traditional disposal technique, through incineration, entails a considerable footprint

Relationship between prolactin plasma levels and white matter volume in women with multiple sclerosis

BACKGROUND: The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS: We employed a chemiluminescence immunoassay for measuring plasma levels of PRL. We used a 1.5 T scanner to acquire images and Jim 4.0 and SIENAX software to analyse them. RESULTS: We included 106 women with relapsing remitting (RR) MS and stable disease in the last two months. There was no difference in PRL plasma levels between patients with and without gadolinium enhancement on MRI. PRL plasma levels correlated with white matter volume (WMV) (rho = 0.284, p = 0.014) but not with grey matter volume (GMV). Moreover, PRL levels predicted changes in WMV (Beta: 984, p = 0.034). CONCLUSIONS: Our data of a positive association between PRL serum levels and WMV support the role of PRL in promoting myelin repair as documented in animal models of demyelination. The lack of an increase of PRL in the presence of gadolinium enhancement, contrasts with the view considering this hormone as an immune-stimulating and detrimental factor in the inflammatory process associated with MS

Isotopic characterization of groundwater for drinking use in multilayer aquifers of the Milano and Monza provinces

Groundwater, drinking water, isotopes, EU directives, hydrogeolog

A central Apennine test site for long-term monitoring: relationship between seismicity and groundwater during 2016-17 earthquakes

Earthquakes hydrology, groundwater, water table, stable isotopes, trace metals

Occurrence of Brettanomyces bruxellensis on Grape Berries and in Related Winemaking Cellar

The spoilage yeasts belonging to the genus Dekkera (anamorph Brettanomyces) are associated with the fermentation process and can be responsible for off-flavors in wine. Brettanomyces bruxellensis is difficult to isolate from natural environments because of its low diffusion, low presence on the grape surface and low competition capacity, slow growth, and VBNC (viable but not culturable) state, even when selective media are used. In this study, to investigate the origins and occurrence of B. bruxellensis in winemaking, a total of 62 samples from grapes, winery environment, and fermenting musts were taken through direct isolation with a selective medium. B. bruxellensis was not directly detected in the grape samples but was instead widely isolated from the winery environment samples. However, using a combination of enrichment and selective media, eight of fifteen grape samples were positive for B. bruxellensis. Analysis of the genetic traits of the isolates indicated a strict relationship among the strains from the vineyard and the winery. Isolates from the vineyard and the winery were both part of the more common and dominant biotypes suggesting that the vineyard may be the contamination source of B. bruxellensis in the winery environment. For this, grapes may represent the possible primary origin source from which a flow toward the winery environment originates. On the other hand, the wide occurrence of B. bruxellensis in winery indicates that this environment can be considered as the favorable ecological niche for colonization and diffusion of these yeast

Myocardial structural, perfusion and metabolic correlates of left bundle branch block mechanical derangement in patient with dilated cardiomyopathy

Background-Left bundle branch block (LBBB) influences upon regional left ventricular (LV) structure, perfusion and metabolism were not thoroughly investigated in dilated cardiomyopathy (DCM) patients. Methods and Results-Eleven DCM patients with LBBB (69?11 years, LV ejection fraction[EF]: 35?8%) and 7 DMC patients without LBBB (58?9 years, LV EF: 37?10%) were studied by cardiac magnetic resonance (CMR) and positron emission tomography (PET). Left ventricle was divided in 3 regions: septum, adjacent (anterior-inferior) and lateral. Regional midwall circumferential strain, maximum shortening (&#1013;peak) and strain rate were obtained from tagged CMR. Systolic stretch index (SSI) was calculated as positive strain rate (stretching) divided by total strain rate. Myocardial metabolic rate of glucose (MMRG), resting and hyperemic myocardial blood flow (MBF) were quantitated using 2-[18F]fluoro-2-deoxyglucose and [13N]ammonia PET, respectively. Conversely from non LBBB patients, LBBB patients showed highly inhomogeneous systolic deformation pattern which changed gradually moving from discoordinate [(SSI: 0.485 (0.284)] and poorly contracting (&#1013;peak: -1.14?0.96%) septum to coordinate [SSI: 0.002 (0.168)] and strongly contracting (&#1013;peak: -13.63?2.58%) lateral region (both P<0.0001). This pattern was closely matched to MMRG distribution disclosing lowest, intermediate and highest values respectively in the septum, adjacent and lateral regions (P<0.0001). Septal-to-lateral thickness ratio was lower in LBBB than non LBBB patients (P=0.03). In both groups, LV distribution of resting and hyperemic MBF and MBF reserve did not differ significantly. Conclusions-In DCM patients, the extensive LV contraction abnormalities induced by LBBB caused regional myocardial metabolic and structural remodeling without consistent changes in blood flows.-