Domino Synthesis of Benzo-fused β,γ-Unsaturated Ketones from Alkenylboronic acids and N-Tosylhydrazone-tethered Benzonitriles

The transition-metal-free domino reaction between alkenylboronic acids and N-tosylhydrazones from o-(2-oxoalkyl)- and o-(3-oxoalkyl)benzonitriles leads to β,γ-unsaturated indanones and tetralones featuring an α-“all-carbon” quaternary center. The employment of derivatives of α-substituted cyclopentanones and cyclohexanones led to the stereoselective preparation of β,γ-unsaturated tetrahydrocyclopenta[a]inden-8(1H)-ones, hexahydrofluorenones, and hexahydroanthracenones as cis-fused single stereoisomers. A domino sequence involving diazo compound formation/reductive alkenylation/1,3-borotropic rearrangement/intramolecular bora-aza-ene reaction is proposed to justify the formation of the products as well as the stereoselectivity

Temas Socio-Jurídicos. Volumen 16 No. 35 Diciembre de 1998

La presente edición de la revista Temas socio-jurídicos, la número 35, en el año 16 de publicación periódica semestral, hace un reconocimiento expreso a la labor intelectual de uno de los creadores de la Facultad de Derecho, el doctor Alfonso Gómez Gómez, al cumplirse cincuenta años de haber optado el título de Doctor en Derecho.This issue of the Temas socio-jurídicos magazine, number 35, in its 16th year of semi-annual publication, expressly acknowledges the intellectual work of one of the creators of the Faculty of Law, Dr. Alfonso Gómez Gómez, by fifty years after having obtained the title of Doctor of Law