Optimizing Resolution and Uncertainty in Bathymetric Sonar Systems

Bathymetric sonar systems (whether multibeam or phase-differencing sidescan) contain an inherent trade-off between resolution and uncertainty. Systems are traditionally designed with a fixed spatial resolution, and the parameter settings are optimized to minimize the uncertainty in the soundings within that constraint. By fixing the spatial resolution of the system, current generation sonars operate sub-optimally when the SNR is high, producing soundings with lower resolution than is supportable by the data, and inefficiently when the SNR is low, producing high-uncertainty soundings of little value. Here we propose fixing the sounding measurement uncertainty instead, and optimizing the resolution of the system within that uncertainty constraint. Fixing the sounding measurement uncertainty produces a swath with a variable number of bathymetric estimates per ping, in which each estimate’s spatial resolution is optimized by combining measurements only until the desired depth uncertainty is achieved. When the signal to noise ratio is sufficiently high such that the desired depth uncertainty is achieved with individual measurements, bathymetric estimates are produced at the sonar’s full resolution capability. Correspondingly, a sonar’s resolution is no-longer only considered as a property of the sonar (based on, for example, beamwidth and bandwidth,) but now incorporates geometrical aspects of the measurements and environmental factors (e.g., seafloor scattering strength). Examples are shown from both multibeam and phase- differencing sonar systems

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation

Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how nucleotide sugars (NSs) are consumed towards host cell and rTP glycosylation. Here, we present a theoretical framework that integrates the reported glycoproteome of CHO cells, the number of N-linked and O-GalNAc glycosylation sites on individual host cell proteins (HCPs), and the carbohydrate content of CHO glycosphingolipids to estimate the demand of NSs towards CHO cell glycosylation. We have identified the most abundant N-linked and O-GalNAc CHO glycoproteins, obtained the weighted frequency of N-linked and O-GalNAc glycosites across the CHO cell proteome, and have derived stoichiometric coefficients for NS consumption towards CHO cell glycosylation. By combining the obtained stoichiometric coefficients with previously reported data for specific growth and productivity of CHO cells, we observe that the demand of NSs towards glycosylation is significant and, thus, is required to better understand the burden of glycosylation on cellular metabolism. The estimated demand of NSs towards CHO cell glycosylation can be used to rationally design feeding strategies that ensure optimal and consistent rTP glycosylation

A Study of Data Processing Employment Opportunities for High School Graduates in the Ogden Area with Implications for Secondary Business Education

LaSalle found that while automation is increasing at an even accelerating pace, little emphasis is apparent in high school curriculums on the significance of automated processes for prospective office workers. He further stated that business education departments should study local situations and prepare students to qualify for available data processing employment. The need for data processing training in the Ogden area is evident in the frequent requests by local employers for people trained in data processing

Water production in comet 81P/Wild 2 as determined by Herschel/HIFI

The high spectral resolution and sensitivity of Herschel/HIFI allows for the detection of multiple rotational water lines and accurate determinations of water production rates in comets. In this Letter we present HIFI observations of the fundamental 1_(10)–1_(01) (557 GHz) ortho and 1_(11)–0_(00) (1113 GHz) para rotational transitions of water in comet 81P/Wild 2 acquired in February 2010. We mapped the extent of the water line emission with five point scans. Line profiles are computed using excitation models which include excitation by collisions with electrons and neutrals and solar infrared radiation. We derive a mean water production rate of 1.0 × 10^(28) molecules s^(−1) at a heliocentric distance of 1.61 AU about 20 days before perihelion, in agreement with production rates measured from the ground using observations of the 18-cm OH lines. Furthermore, we constrain the electron density profile and gas kinetic temperature, and estimate the coma expansion velocity by fitting the water line shapes

Acoustic positioning and tracking in Portsmouth Harbour, New Hampshire

Portsmouth Harbor, New Hampshire, is frequently used as a testing area for multibeam and sidescan sonars, and is the location of numerous ground-truthing studies. Having the ability to accurately position underwater sensors is an important aspect of this type of work. However, underwater positioning in Portsmouth Harbor is challenging. It is relatively shallow, approximately one kilometer wide with depths of less than 25 meters. There is mixing between fresh river water and seawater, which is intensified by high currents and strong tides. This causes a very complicated spatial and temporal sound speed structure. Solutions that use the time-of-arrival of an acoustic pulse to estimate range will require very precise knowledge of the travel paths of the signal in order to separate out issues of multipath arrivals. An alternative solution is to use the phase measurements between closely spaced hydrophones to measure the bearing of an acoustic pinger. By using two bearing measurement devices that are widely separated, the intersection of the two bearings can be used to position the pinger. The advantage of this approach is that the sound speed only needs to be known at the location of the phase measurements. Both time-of-arrival and phase difference systems may encounter difficulties arising from horizontal refraction due to spatially varying sound speed. To ascertain which solution would be optimal in Portsmouth Harbor, the time-of-arrival and phase measurement approaches are being examined individually. Initial field tests have been conducted using a 40 kHz signal to look at bearing accuracy. Using hydrophones that are spaced 2/3 wavelengths apart, the bearing accuracy was found to be 1.25deg for angles up to 20deg from broadside with signal to noise ratios (SNR) greater than 15 dB. The results from the closely spaced hydrophones were used to resolve phase ambiguities, allowing finer bearing measurements to be made between hydrophones spaced 5 wavelengths apart. The fi- ne bearing measurements resulted in a bearing accuracy of 0.3deg for angles up to 20deg from broadside with SNR greater than 15 dB. Field tests planned for summer 2007 will include a more detailed investigation of how the environmental influences affect each of the measurement types including range, signal to noise ratio, currents, and sound speed structure

Hospital admission patterns subsequent to diagnosis of type 1 diabetes in children : a systematic review

Background Patients with type 1 diabetes are known to have a higher hospital admission rate than the underlying population and may also be admitted for procedures that would normally be carried out on a day surgery basis for non-diabetics. Emergency admission rates have sometimes been used as indicators of quality of diabetes care. In preparation for a study of hospital admissions, a systematic review was carried out on hospital admissions for children diagnosed with type 1 diabetes, whilst under the age of 15. The main thrust of this review was to ascertain where there were gaps in the literature for studies investigating post-diagnosis hospitalisations, rather than to try to draw conclusions from the disparate data sets. Methods A systematic search of the electronic databases PubMed, Cochrane LibrarMEDLINE and EMBASE was conducted for the period 1986 to 2006, to identify publications relating to hospital admissions subsequent to the diagnosis of type 1 diabetes under the age of 15. Results Thirty-two publications met all inclusion criteria, 16 in Northern America, 11 in Europe and 5 in Australasia. Most of the studies selected were focussed on diabetic ketoacidosis (DKA) or diabetes-related hospital admissions and only four studies included data on all admissions. Admission rates with DKA as primary diagnosis varied widely between 0.01 to 0.18 per patient-year as did those for other diabetes-related co-morbidity ranging from 0.05 to 0.38 per patient year, making it difficult to interpret data from different study designs. However, people with Type 1 diabetes are three times more likely to be hospitalised than the non-diabetic populations and stay in hospital twice as long. Conclusion Few studies report on all admissions to hospital in patients diagnosed with type 1 diabetes whilst under the age of 15 years. Health care costs for type 1 patients are higher than those for the general population and information on associated patterns of hospitalisation might help to target interventions to reduce the cost of hospital admissions