Stages of economic substantiation analysis and modeling for the meat processing companies’ price strategy

The authors have presented the stages of economic substantiation analysis and modeling for making decisions on the price strategy as part of management accounting in the articl

Optimization of Reproduction Stage in Technology of Production of Plague Diagnostic Bacteriophage L-413C

New nutrient media based on baker yeast autolizate were used for the first time for manufacturing of diagnostic preparation of plague bacteriophage L-413C. Experimental media provide high concentration of phage particles at the stage of propagation, and good survivability in lyophilization. Media in which yeast autolizate was a nutrient protein basis appeared to be more effective than those in which it was a stimulating additive. Phage preparations preserved stability of properties during storage at 4-8 °С, and at a higher temperature in the test of accelerated aging. Introduction of yeast nutrient media in technology of plague diagnostic bacteriophage L-413C manufacturing opens good prospects for increasing of production efficiency and decreasing of cost value of the preparatio

Enhancement of the Technology for Live Tularemia Vaccine Production

Objective of the study was to develop and test new biotechnological approaches for live tularemia vaccine production.Materials and methods: Francisella tularensis 15 NIIEG strain was used as producer-strain; Francisella tularensis 503 strain – as test infecting one. Producer strain was cultivated on solid and liquid nutrient media. Tangential ultrafiltration was performed with the help of microfiltration module “Viva-flow”. Lyophilization was conducted using drying installation – Free Zone 2.5 L.Results and discussion: Application of the designed liquid nutrient medium on the basis of enzymatic fibrin hydrolysate and submerged cultivation of the producer-strain has allowed for a significant biomass yield increment. At the stage of tularemia microbe culture concentration via microfiltration through filtering membranes with pore size of 0.2 μm, in the mode of tangential liquid flow, increased has been the content of microbe cells; the nutrient media residues – removed. Comparative analysis of the obtained in accordance with experimental technique laboratory series of the vaccine and commercial preparation of live tularemia vaccine has demonstrated their conformity with the specific normative properties. It is established that application of modified liquid nutrient medium, submerged cultivation conditions, methods of biomass concentration and separation has no negative influence on the main properties of live tularemia vaccine and will provide for considerable produce-ability increase in the future

Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains

Carried out has been comparative assessment between the performances of liquid nutrient pancreatic fibrin overcook-based and bakery yeast autolyzate-based media and conventionally used in manufacturing of cholera vaccine media for submerged cultivation of Vibrio cholerae 569B and V. cholerae M-41 strains. Results of investigation of media quality biological predictors (morphological and biochemical property stability, efficacy of biomass and protective antigen accumulation), which are fibrin hydrolyzate and bakery yeast autolyzate-based, suggest the possibility of using them for the production of cholera vaccine. Deployment of inedible raw material-based media in manufacturing of cholera vaccine is a prospective technology in view of reduction of medical-prophylactic preparation costs. Moreover it allows for solving the problem of protein waste-product disposal, which is generated in the process of anti-rabies immunoglobulin manufacturing, thus decreasing ecological impact on the environment

Non-Waste Alternative Technologies in the Production of Heterologous Anti-Rabies Immunoglobulin

Presented is a comprehensive approach to utilization of the wastes that appear in the process of heterologous anti-rabies immunoglobulin production (packed red cells, fibrin, and alcohol-containing products). Specific immunoglobulin is extracted from the surface of red blood cells using desorption technique. Additional yields of immunoglobulin after exposure of erythrocytes to non-ionic detergent amount to 10-19 % of the output. Rich protein supplement feeding for horses-producers is obtained from spray-dried packed red cells. Solid nutritious substrate for microbiological media production is obtained from fibrin using enzymic hydrolysis method. The efficiency of the fibrin hydrolysate-based media is 1.5-2 times higher in comparison with that of the media based on the digest of meat and casein, as demonstrated by the results of Vibrio cholerae scaled cultivation. Furthermore, worked out is the technology of ethanol regeneration after the rivanol-ethanolic precipitation of gamma globulin, alcohol content by volume being (93±1) % after the regeneration. It is demonstrated that the regenerated alcohol can be used as a precipitator in the process of anti-rabies serum fractioning. All in all, the developed techniques make it possible to utilize the wastes of anti-rabies immunoglobulin production and provide for further use of derivatives while producing medical immunobiological preparations

NEW NUTRIENT MEDIUM ON THE BASIS OF DRY FIBRIN HYDROLYSATE FOR V. CHOLERAE CULTIVATION

The data on exploration of biological properties of experimental solid and liquid media on the basis of dry enzymatic hydrolysate of fibrinobtained from production waste of anti-rabies immunoglobulin is presened here. The culture media engineered meets the requirements of normative documents and. is highly competitive with the test medium in their qualitative characteristics. Suggested media can be used for V. cholerae cultivation, including submerged cultivation, in production of cholera preventive and. diagnostic preparations

Universities’ Intellectual Capital Report: The Formation Concept, Analytical Capabilities under Stakeholders Management Decisions-Making

The modern trends in the socio-economic life, educational and research spheres lead to the increased attention of universities to the more effective management of available resources, as well as high-quality and relevant disclosure of information in their public reporting to the interested parties. Under the circumstances, the intellectual capital (IC) components become key objects in the management accounting systems, and the IC report may become one of the main engines to achieve the transparent information which can raise the interest of stakeholders. The analysis of this practice clarified the discussion points and helped to develop conceptual guidelines for the preparation of the IC report for Russian universities. There have been used the following methods to solve the problem, such as quantitative-systematic analysis, semantic grouping of results and logical relationships. The developed methodology for analyzing the report on IC universities has a certain practical importance. Such methodology also includes methods of financial and management analysis. The formulated recommendations are intended for a wide range of stakeholders, the leadership of the Russian Ministry of Education and Science and higher education institutions

Standardization of Russian Management Accounting as a Condition for its Further Development

The subject of this article is the multitude of processes of management accounting standardization. Its goal is to justify the need for standardization of management accounting as an initial stage in the development of its institutional environment and working out ways to solve this problem.To achieve this goal, the present article analyzes Russian and foreign scientific publications which are devoted to the problems of standardization of the accounting system, and critically assesses the current practice in the field of standardization of management accounting. In the process of research, the methods of logical and expert analysis were used.The article outlines the negative consequences of the lack of institutional regulation of management accounting inRussia— both for the further development of its theory and for practical advancement. The negative impact of the current situation on the educational process was especially noted.The urgent need for standardization of Russian management accounting as the first stage of the institution of its institutional regulation has been revealed. Particular attention is paid to possible directions of standardization of management accounting in the public sector, as well as the development of a professional standard «Managerial Accounting Specialist».The conclusion is made on the need to standardize management accounting at two levels — macroeconomic, which involves developing standards that take into account the specifics of different sectors of the economy, and at the level of microeconomics, which means the development of internal standards and regulations directly by business entities, taking into account the first-level standards

The Relationship Between Procedures of Management Accounting and Internal Control

The article substantiates the objectively growing importance of internal control and management accounting systems in the context of an impending global financial and economic crisis. The research methodology is based on the application of historical analysis and synthesis methods, systemic and logical approaches, the method of analogies and groupings. The research defines the place of managerial accounting in the organization’s internal control system, identifies the procedures for these systems and the sequence of their practical implementation. The authors determine the possibilities and ways of incorporating management accounting procedures into internal control procedures and draw a conclusion about the existing duplication of some of them. The article substantiates the principles compliance with which will ensure the success of the implementation under discussion. The results of the study can be useful in the process of setting up and developing systems of internal control and management accounting in Russian business structures, primarily representing small and medium businesses

Stages of economic substantiation analysis and modeling for the meat processing companies’ price strategy

The authors have presented the stages of economic substantiation analysis and modeling for making decisions on the price strategy as part of management accounting in the articl