A study of evaluation of various risk factors of retinal vein occlusion

Background:A study of various ocular & systemic risk factors in Retinal Vein Occulation (RVO) at tertiary eye care centre.Methods:A prospective study included 50 eyes of 50 patients, in period of September 2010 to August 2012. Inclusion criteria: 1. Age >25 years, 2. All newly diagnosed cases of vein occlusion. Exclusion criteria: 1. Age <25 years 2. All other ocular diseases causing significant visual impairment. A detailed history, ophthalmic & systemic examinations with all necessary investigations-as and when required were done.Results: In our study, RVOs were more common in males – 26 (52%) & in 56-65 years of age group - 16 (32%). BRVO (Branch Retinal Vein Occlusion)s were more common than CRVO (Central Retinal Vein Occlusion) - Nonischemic (26%) >Ischemic (24%). In risk factors - most common was hypertension - in 38 (76%) patients. Followed by descending order, hyperlipidemia 27 (54%) >diabetes mellitus 16 (32%) >tobacco 14 (28%) >hyper homocystinemia 4 (8%) >severe alcohol 2 (4%). The complications were more in ischemic than Nonischemic-CRVO >BRVO - they were macular edema 43 (86%) >neovascularization at iris - 14 (28%) >neovascularization at angle - 10 (20%) >neovascular glaucoma – 4 (8%). Conclusion:RVOs are more common with increasing age, in males & most common risk factor is hypertensive. Most common cause for vision loss is macular edema - ischemic >non-ischemic.

An unusual case of orbital involvement and pan-ocular inflammation in Acute Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. At the onset, SLE may involve only one organ (additional manifestations may occur later) or multiple organs. The ocular manifestations are varied and involve the lids, cornea, sclera and or orbit. There may be associated secondary Sjogren's syndrome, conjunctival haemorrhages, retinal vascular disease with retinal haemorrhages and neuro-ophthalmic lesions. Pan-ophthalmic involvement is rare and sight threatening and requires urgent ophthalmic intervention. We hereby present an unusual case of pan-ophthalmic inflammation in case of acute systemic lupus

Imaging features of double aortic arch shown by multidetector computed tomography angiography

We present a three-dimensional reconstructed image of vascular ring in a 2.5-month-old patient, which was obtained using multidetector computed tomography (MDCT). MDCT angiography made an accurate diagnosis of this life-threatening, but correctable, anomaly in an infant with a stridor, repeated respiratory infections and episodes of apnea

SIMULTANEOUS ESTIMATION OF RABEPRAZOLE SODIUM AND ACECLOFENAC COMBINED CAPSULE DOSAGE FORM AS PER ICH GUIDELINE BY UV SPECTROSCOPIC METHODS

The present work aimed to develop and validate spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac in a pure and capsule dosage form. A simple, sensitive, spectrophotometric method in UV region has been developed for the simultaneous estimation of Rabeprazole sodium and Aceclofenac in bulk and semi dosage form (Capsule). Standard solution of Rabeprazole sodium shows maximum absorbance at 283 nm and Aceclofenac shows maximum absorbance at 276 nm. Beer’s Lamberts law is obeyed in concentration range 10-60 µg/ml for Rabeprazole with regression, slope and intercept of 0.991, 0.0918 and 0 respectively while for, Beer’s Aceclofenac Lambert law is obeyed in concentration range 10-60 µg/ml with regression, slope and intercept having 0.9984, 0.2069 and 0.0253 respectively. Method was validated for linearity, range, accuracy, precision, recovery studies and interference study of mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in combination formulations. Keywords: Rabeprazole sodium, Aceclofenac, Simultaneous equations, absorbance interference stud

Perventricular device closure of isolated muscular ventricular septal defect in infants: A single centre experience

Objectives: To evaluate prospective single centre experience of mid-term safety and efficacy of perventricular device closure of isolated large muscular ventricular septal defect (mVSD) in high-risk infants. Background: Surgical closures of large mVSD in infants represent a challenge with significant morbidity. Methods: Between August 2008–2010, perventricular closure was attempted in 24 infants of 6.01 ± 2.37 months age and 4.27 ± 0.56 kg weight under TEE guidance. Results: The device was successfully deployed in 21/24 infants. Size of mVSD was 8.42 ± 1.46 mm (6.1–12 mm). Mean procedure time was 28.8 ± 11.7 min. The closure rate was 84% immediately and 100% at 6 months. Four patients suffered major complications: 2-died, 1-esophageal perforation, 1-persistent CHB. At 26.23 ± 6.63 months follow-up two patients were symptomatic: 1-required device retrieval, 1-died of severe gastroenteritis. Conclusion: Perventricular device closure of isolated mVSD appears feasible option at mid-term follow-up and may either substitute or complement the conventional surgical technique in selected cases depending on institutional paediatric cardiac surgery performance

STUDY OF CONGENITAL MALFORMATION IN NEONATES BORN AT TERTIARY CARE HOSPITAL

ABSTRACT Introduction: Congenital malformations are major contributors of neonatal mortality or lifelong disability. Early diagnosis and early surgical treatment when required can prevent neonatal deaths and help for better survival

Additional file 1 of Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways

Additional file 1. Representative Western blot images with respective loading control (GAPDH)

Assessment of Gene Action and Identification of Heterotic Hybrids for Enhancing Yield in Field Pea

Eight field pea parental lines and their twenty-eight F1s resulting from diallel design (excluding reciprocal) were analyzed for their combining ability and heterosis for yield and associated traits. ANOVA revealed significant variation among parents and among hybrids for days to 50% flowering, plant height, total number of pods, effective pods, seeds per pod, 100-seed weight, biological yield and seed yield; pod length also revealed significant differences among hybrids, suggesting the occurrence of considerable variability for studied traits. Crosses P-1541-16 × P-92-97-11 and P-1541-16 × P-1297-97 displayed significant heterosis over better-parent and control varieties for seed yield and associated traits. Combining ability analysis showedthat SCAvariance was considerably higher than corresponding GCAvariance for all traits. Genotype Aman and P-1297-97 were identified as good general combiners for seed yield, while cross P-1541-16 × P-1297-97, Aman × EC-564817, P-1541-16 × P-92-97-11 and P-1297-97 × P-92-97-11 were identified as specific cross-combiners for most of the studied traits. Consequently, these crosses might be exploited in future breeding programs to find desired segregants. PCA explained 81.68% and 83.34% variability in parents and crosses, respectively, for yield component. Furthermore, trait association between GCA effects and SCA effects demonstrates that biological yield, total number of pods, and effective pods exhibit additive gene action, but 100-seed weight exhibits non-additive gene action

Abstracts of Scientifica 2022

This book contains the abstracts of the papers presented at Scientifica 2022, Organized by the Sancheti Institute College of Physiotherapy, Pune, Maharashtra, India, held on 12–13 March 2022. This conference helps bring researchers together across the globe on one platform to help benefit the young researchers. There were six invited talks from different fields of Physiotherapy and seven panel discussions including over thirty speakers across the globe which made the conference interesting due to the diversity of topics covered during the conference. Conference Title:  Scientifica 2022Conference Date: 12–13 March 2022Conference Location: Sancheti Institute College of PhysiotherapyConference Organizer: Sancheti Institute College of Physiotherapy, Pune, Maharashtra, Indi