An interesting case of intrauterine torsion of ovarian cyst in a female fetus

Fetal ovarian cysts are usually benign and managed conservatively. We report an interesting case of fetal ovarian cyst diagnosed in the antenatal period. Post-delivery, neonate was operated for torsion of the ovarian cyst. The baby recovered well.

Oral antifungal: the safety and efficacy of oral itraconazole in dermatophytosis

Background: The systemic antifungals like Griseofulvin, Itraconazole, Terbinafine, Ketoconazole and Fluconazole are widely used for superficial fungal infection. Hepatotoxicity with oral antifungals is well established fact. The rate of transient asymptomatic changes in liver function tests accounts for about 0.5 - 10% of all patients treated with systemic antifungals. Clinical hepatic toxicity is seen less frequently. The aim of this study is to evaluate the effect of oral Itraconazole on hepatic function and it’s efficacy in patients with extensive dermatophytosis.Methods: The total of 524 patients with extensive dermatophytosis were included in our study which was conducted in a tertiary care hospital in Navi Mumbai.Results: Itraconazole, a systemic antifungal agent is efficiently used in treatment of superficial and deep mycoses. It inhibits fungal cytochrome P450 dependent enzyme and thus impaires conversion of lanosterol to ergosterol. Adverse reactions to itraconazole includes drug reactions, gastrointestinal upset, headache, dizziness, thrombocytopenia, gynecomastia, reversible edema of extremities and metabolic side effects like hypokalemia, and hypertriglyceridemia. The level of hepatic transaminases increases in about 1%-5% of patients who have received continuous therapy with systemic itraconazole. Clinical hepatitis rarely occurs in patients and, recovery generally ensues with the cessation of medication.Conclusions: The baseline and post treatment liver function test is important to monitor if patient is on higher dose and longer duration of itraconazole therapy. The screening for high risk patients like poor liver function test, history of alcoholism, history of liver disease should be taken before stating the therapy

Assessment of carrot growth performance with inoculation of AsT-PGPR under arsenic infested zone

In the present study, the maximum rhizobacterial population was observed in Nutrient Agar (NA) (average; Cfu=135×106) followed by King’s-B (average; Cfu=57×106), Soil extract agar (SEA) (average; Cfu=11×106), and Trypticase soy agar (TSA) (average; Cfu=9×106). Screening of arsenic tolerant rhizobacterial isolate revealed that about 1% of the bacterial isolate was from Nutrient Agar and King’s-B survived at 20ppb arsenic concentration, while 0.8% and 0.7% survived from TSA and SEA media respectively. 50ppb arsenic tolerant rhizobacteria were screened for plant growth-promoting activity such as IAA, Phosphate solubilization, Siderophore production, ACC deaminase activity. Maximum IAA activity was observed in rhizobacterial isolates, isolated from all different media. P- solubilizer, Siderophore producer, ACC deaminase, proline, and TSS activities were observed in the isolates of NA media followed by King’s-B media. 50ppb tolerate best suitable PGP traits producing isolates were inoculated to observe carrot plant growth in the pot experiment, Interesting and significant (p<0.05) result were observed in King’s-B media producer isolates; (Pseudomonas) induces plant length, chlorophyll-a and chlorophyll-b content of the plant after 60 days followed by 30 days